Seagrasses extracts as potential mosquito larvicides in Saudi Arabia

Al-Rashidi, Hayat S.; Mahyoub, Jazem A.; AlGhamdi, Khalid M.; Al-Otaibi, Wafa Mohammed

doi:10.1016/j.sjbs.2022.103433

Cited by 12 publications

(18 citation statements)

References 19 publications

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“…The studies on emergence of surviving larvae treated with drugs and the fecundity of adult female Ae. albopictus , which came from the surviving larvae, can prove whether MA and its derivatives have an effect on the growth cycle of mosquitoes and provide directions for subsequent studies [ 47 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis

et al. 2023

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A large number of studies have shown that matrine (MA) possesses various pharmacological activities and is one of the few natural, plant-derived pesticides with the highest prospects for promotion and application. Fifty-eight MA derivatives were prepared, including 10 intermediates and 48 target compounds in 3 series, to develop novel mosquitocidal agents. Compounds 4b, 4e, 4f, 4m, 4n, 6e, 6k, 6m, and 6o showed good larvicidal activity against Aedes albopictus, which is both a highly aggressive mosquito and an important viral vector that can transmit a wide range of pathogens. Dipping methods and a bottle bioassay were used for insecticidal activity evaluation. The LC50 values of 4e, 4m, and 6m reached 147.65, 140.08, and 205.79 μg/mL, respectively, whereas the LC50 value of MA was 659.34 μg/mL. Structure–activity relationship analysis demonstrated that larvicidal activity could be improved by the unsaturated heterocyclic groups introduced into the carboxyl group after opening the D ring. The MA derivatives with oxidized N-1 lost their mosquitocidal activities, indicating that the bareness of N-1 is crucial to maintain their anti-mosquito activity. However, the activity was not greatly influenced by introducing a cyan group at C-6 or a benzene sulfonyl group at N-16. Additionally, compounds 4e and 4m exhibited good inhibitory activities against acetylcholinesterase with inhibitory rates of 59.12% and 54.30%, respectively, at a concentration of 250 μg/mL, whereas the inhibitory rate of MA was 9.88%. Therefore, the structural modification and mosquitocidal activity of MA and its derivatives obtained here pave the way for those seeking strong mosquitocidal agents of plant origin.

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Section: Resultsmentioning

confidence: 99%

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis

et al. 2023

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“…Como se observa en la Tabla 3, la LC50 disminuyó del 57.5 % al 87.5 % a las 48 y 72 h, respectivamente. Esto indica que los 13 compuestos identificados en el extracto metanólico de hojas de A. mexicana, podrían estar interactuando en sitios sensibles en el cuerpo del insecto a medida que la concentración del extracto incrementa y se acumula con el tiempo de exposición; a través de la disminución de enzimas secretadas por el insecto como mecanismo de protección y reguladores del crecimiento (Al-Rashidi et al, 2022).…”

Section: Resultados Y Discusiónunclassified

EN PRENSA. Efecto insecticida del extracto metanólico de Argemone mexicana para el control de Bactericera cockerelli (Sulc.) (Hemiptera: Triozidae).EN PRENSA

Ortiz

López-López²,

Beltrán-Beache³

et al. 2023

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Argemone mexicana L. es una maleza, la cual es utilizada como planta medicinal. La actividad biológica de esta planta se ha observado en patógenos como virus, hongos, bacterias, protozoos y plagas de cultivos agrícolas; dicha actividad se atribuye a compuestos como flavonoides, glucósidos, terpenoides, compuestos fenólicos y alcaloides presentes en la planta. El objetivo del estudio fue evaluar el efecto del extracto metanólico de A. mexicana como insecticida sobre Bactericera cockerelli. Se detectaron 13 metabolitos por cromatografía de gases acoplada a espectrometría de masas; siendo seis los que tienen reporte de actividad biológica; el compuesto identificado como 5,7,8,15-Tetrahidro-3,4-dimetoxi-6-metil[1,3]benzodioxolo[5,6-e][2]benzazecin-14(6H)-ona es el segundo con mayor abundancia y es un alcaloide de bencilisoquinolina. La mortalidad observada a las 48 h fue de 83.6 y 83.9 % dependiente de las dosis altas de 20 y 30 mg/mL; mientras que a las 72 h se observó un aumento de la mortalidad hasta en un 97.2 % a las concentraciones de 8-30 mg/mL. La concentración letal media fue de 7.63 mg/mL y una CL95 de 107.98 mg/mL. El análisis del extracto metanólico de las hojas de A. mexicana reveló que puede ser empleado como insecticida de origen vegetal al causar mortalidad en ninfas de B. cockerelli.

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“…Moreover, prolonged use of pesticides renders mosquitoes resistant and thus presents the biggest obstacle to the control of medically significant arthropod pests and will directly contribute to the re-emergence and outbreak of vector-borne diseases over a wide geographic scale of the world ( Georghiou and Taylor, 1986 , Smith et al, 2016 , WHO, 1976 ). In contrast, some herbs have insecticidal properties that have enabled them to be used as environmentally friendly control alternatives in the past few years to replace dangerous chemical pesticides ( Al-Rashidi et al, 2022 , Hazarika et al, 2018 ). Essential oils from natural plants are one of the most important alternatives for their ease of obtaining and low cost compared to synthetic chemical products.…”

Section: Discussionmentioning

confidence: 99%

“…Essential oils from natural plants are one of the most important alternatives for their ease of obtaining and low cost compared to synthetic chemical products. Moreover, they do not leave residues in the environment because they are extracted from renewable sources and decompose quickly ( Al-Rashidi et al, 2022 , Hazarika et al, 2018 ) and they do not develop insect resistance ( Kusuma and Mahfud, 2017 , Mashlawi et al, 2022 ). Thus, using essential oils for mosquito control is an environmentally safe option compared to harmful synthetic insecticides.…”

Section: Discussionmentioning

confidence: 99%

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Larvicidal effects of some essential oils against Aedes aegypti (L.), the vector of dengue fever in Saudi Arabia

Aljameeli

2023

Saudi Journal of Biological Sciences

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Seagrasses extracts as potential mosquito larvicides in Saudi Arabia

Cited by 12 publications

References 19 publications

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis

Novel Matrine Derivatives as Potential Larvicidal Agents against Aedes albopictus: Synthesis, Biological Evaluation, and Mechanistic Analysis

EN PRENSA. Efecto insecticida del extracto metanólico de Argemone mexicana para el control de Bactericera cockerelli (Sulc.) (Hemiptera: Triozidae).EN PRENSA

Larvicidal effects of some essential oils against Aedes aegypti (L.), the vector of dengue fever in Saudi Arabia

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