Sealed-capsule Irrigation with Distilled Deionized Water to Prevent Posterior Capsule Opacification – Prospective, Randomized Clinical Trial

Rękas, Marek; Kluś, Adam; Kosatka, Mariusz

doi:10.3109/02713683.2012.748079

Cited by 19 publications

(15 citation statements)

References 39 publications

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“…Its osmotic pressure is approximately 0, which is obviously lower than the osmotic pressure of human tissue cells that is within 280 mmol/L∼310 mmol/L, and DW can cause cells bursting by absorbing water to help eliminate cells. Scholars [3,48] infused the capsule with DW for 3 minutes after removing the lens cortex in human cataract surgery and proved that DW could reliably eliminate LECs and decrease the occurrence of lens capsule opacification. For protecting intraocular tissues, Rekas et al…”

Section: Clinical Drugs On Clearing Lecsmentioning

confidence: 99%

“…Scholars found that LECs include two types, type A and type E LECs. Type A LECs that are located under the anterior capsule have two major functions, EMT and migration towards the equatorial and posterior capsule, whereas equatorial type E LECs with a superior proliferation ability play a critical role in the formation of capsular pearls [3]. In the process of routine operation, most of type A LECs can be eliminated via capsulorhexis, while both type A LECs around the anterior capsule and whole type E LECs hidden by the iris are difficult to remove.…”

Section: Introductionmentioning

confidence: 99%

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Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery

Zhang

Xie

2020

Journal of Ophthalmology

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Phacoemulsification combined with intraocular lens (IOL) implantation is the international standard operation procedure for cataract and has been generalized worldwide. However, lens capsule opacification, one of the common complications after cataract surgery, impacts the recovery of patients’ visual function to a large extent. Lens capsule opacification has two types, anterior capsule opacification (ACO) and posterior capsule opacification (PCO), according to the location. There is not an accepted approach to treat ACO. Nd : YAG laser capsulotomy, the common treatment of PCO, can effectively improve the vision, but may cause a series of complications and is inappropriate for children who are too young to cooperate with this treatment. It is generally known that the responses of lens epithelial cells (LECs) after cataract surgery, including cell proliferation, migration, and epithelial-mesenchymal transition (EMT), play a key role in the pathogenesis of lens capsule opacification. Scholars found that substantial drugs can reduce the occurrence of lens capsule opacification by inhibiting, clearing, or killing LECs, and made great efforts as well as innovations on the exploration of drug species or modes of administration. This article is a systematic interpretation and elaboration about how to prevent lens capsule opacification after cataract surgery via different drugs.

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Section: Clinical Drugs On Clearing Lecsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery

Zhang

Xie

2020

Journal of Ophthalmology

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“…We decided to test two basic substances for PCO prevention, distilled water (H 2 Od) and hydrogen peroxide (H 2 O 2 ). H 2 Od since it has been tested many times before 11 , 13 , 17 , 20 – 22 and gives us a point of reference with other similar studies, although its effectiveness has been inconsistent. H 2 O 2 was selected due to its known presence in the lens 23 and its dichotomous role in mammalian cells, being harmful or beneficial depending on its location and concentration.…”

Section: Introductionmentioning

confidence: 95%

Prevention of posterior capsule opacification through intracapsular hydrogen peroxide or distilled water treatment in human donor tissue

D’Antin

Barraquer

Tresserra

et al. 2018

Sci Rep

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In order to determine whether posterior capsule opacification after cataract surgery, could be delayed or inhibited through the application of hydrogen peroxide (H2O2) or distilled water (H2Od),we extracted lens capsules from 25 human donor eye globes. Samples were treated for 5 min with either 30 mM H2O2 or H2Od or used as controls, and cultured for one month, during which dark field and tilt illumination photos were taken. These were used to observe and quantify, time until cellular growth and confluence on the posterior capsule. After culture, histological sections were stained for H&E, α-SMA, Ki-67 and vimentin and evaluated. We prevented cellular growth in 50% of H2Od and 58% H2O2 of treated samples. The overall prevention of cell growth compared to cultured controls was significant for both treatments while there was no significant difference between them. In the cases where cellular growth was not prevented, both treatments significantly delay cellular growth. Until day 28 none of the treated samples of either type that had shown growth reached total confluence. All cultured controls reached total confluence before treated samples (median = day 11.5). Also, histologically, there was a clear morphological difference between cultured controls and treated samples.

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“…Sealed-capsule irrigation using either distilled water or 5-fluorouracil has been shown to be successful in reducing the incidence of visual axis opacification in adult eyes by killing the LECs. 142 , 143 This device may help pediatric cataract surgeons to overcome the problem of PCO, but the risk of endothelial cell loss cannot be underestimated. The development of the bag-in-the-lens technique by Tassignon et al shows promise, because by using this lens the LECs are trapped between the anterior and posterior capsules, thus reducing dramatically the rate of PCO.…”

Section: Complicationsmentioning

confidence: 99%

“…Capsule-irrigating devices customized for pediatric eyes, which will reduce the speed and severity of proliferation of LECs, or future research discovering the drugs antagonizing the effect of factors responsible for PCO are warranted. 142 , 143 Recently, the results in an animal model indicated that there was a beneficial effect on postoperative inflammation with dexamethasone-coated IOLs. 149 It is reasonable to assume that IOLs will be designed that can deliver slow-release molecules to reduce inflammation and obviate the need for topical anti-inflammatory treatment.…”

Section: Future Directionsmentioning

confidence: 99%

Pediatric cataract: challenges and future directions

Medsinge

Nischal²

2015

OPTH

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Cataract is a significant cause of visual disability in the pediatric population worldwide and can significantly impact the neurobiological development of a child. Early diagnosis and prompt surgical intervention is critical to prevent irreversible amblyopia. Thorough ocular evaluation, including the onset, duration, and morphology of a cataract, is essential to determine the timing for surgical intervention. Detailed assessment of the general health of the child, preferably in conjunction with a pediatrician, is helpful to rule out any associated systemic condition. Although pediatric cataracts have a diverse etiology, with the majority being idiopathic, genetic counseling and molecular testing should be undertaken with the help of a genetic counselor and/or geneticist in cases of hereditary cataracts. Advancement in surgical techniques and methods of optical rehabilitation has substantially improved the functional and anatomic outcomes of pediatric cataract surgeries in recent years. However, the phenomenon of refractive growth and the process of emmetropization have continued to puzzle pediatric ophthalmologists and highlight the need for future prospective studies. Posterior capsule opacification and secondary glaucoma are still the major postoperative complications necessitating long-term surveillance in children undergoing cataract surgery early in life. Successful management of pediatric cataracts depends on individualized care and experienced teamwork. We reviewed the etiology, preoperative evaluation including biometry, choice of intraocular lens, surgical techniques, and recent developments in the field of childhood cataract.

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Sealed-capsule Irrigation with Distilled Deionized Water to Prevent Posterior Capsule Opacification – Prospective, Randomized Clinical Trial

Abstract: SCI is a safe procedure and the endothelial cells loss can be associated with the Perfect Capsule™ device (Milvella) in the anterior chamber insertion. DW irrigated for 3' reduces PCO in long-term follow-up.

Cited by 19 publications

References 39 publications

Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery

Research Progress of Drug Prophylaxis for Lens Capsule Opacification after Cataract Surgery

Prevention of posterior capsule opacification through intracapsular hydrogen peroxide or distilled water treatment in human donor tissue

Pediatric cataract: challenges and future directions

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