Search for New and Novel Chemotherapeutics for the Treatment of Human Malignancies

Abstract

One of the hallmarks of cancer is the uncontrolled cell proliferation which causes more deaths among the human diseases throughout the globe. One in eight deaths worldwide are due to cancer, it is the second and third leading cause of death in economically developed and developing countries, respectively. As it is caused by both external and internal factors, a balanced approach to cancer control includes prevention, early detection, and effective treatment. In the treatment of cancer, chemotherapy is one of the practical methods and is widely used employing drugs that can destroy cancer cells by impeding their growth and reproduction. Despite the great strides made in the treatment of cancer over the past 50 years, it continues to be a major health concern and therefore, extensive efforts have been devoted to search for new scaffolds to develop chemotherapeutics. In this perspective, over the past two decades from this laboratory extensive efforts have been made in the development of new chemotherapeutic agents for the treatment of cancer. In this review, glimpses on types of current chemotherapeutic agents based on their action of inhibition and the new molecules that are being developed based on the scaffolds such as pyrrolo[2,1-c][1,4]benzodiazepines, podophyllotoxins, benzothiadiazine 1,1-dioxides, naphthalimides and monastrol across the world as well as in this laboratory have been articulated.

An orthomanganation route to 2-substituted derivatives of N-methyl-1,8-naphthalimide

“…Derivatives find application as colorimetric and fluorescent sensors [1e3], and have promising chemotherapeutic properties [4,5]. Their photophysical properties are also of interest for electrochemical applications [6].…”

New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation

“…However, the only hit that had annotated protein connections in STRING is the benzothiadiazine dioxide (Tc -0.65). There is evidence in the biomedical literature that benzothiadiazine-1,1-dioxides are promising therapeutic options for human malignancies (50,51) and human cytomegalovirus (HCMV) infections (52). Some derivatives are positive allosteric modulators of AMPA receptors (53) and others are considered ionotropic glutamate receptor ligands.…”

Biodegradable Cyclomatrix Polyphosphazene Nanoparticles: A Novel pH-Responsive Drug Self-Framed Delivery System

“…Development of effective cancer treatments is an urgent issue in modern medicine as a consequence of the sharply increasing number of deaths caused by a variety of malignancies. Among various cancer therapies, chemotherapy is vitally important contributing to the high-efficiency in killing tumor cells . Unfortunately, the lethality of cancer is still high.…”