Introduction. Information about mycoses and antifungal drugs of the modern type is often fragmentary and unsystematic, which requires correction.Aim. To systematize the latest information about fungi and mycoses, means of combating them and the problems encountered along the way, to highlight the latest achievements in the field of synthesis and research of the activities of 1,2,4-triazole as a potential fungicidal compound.Materials and methods. The materials were the authors' research published in advanced scientific journals, conducted around the world in the field of studying fungi, antifungal drugs, and the search for new antifungal agents.Results and discussion. The article provides an overview of current information on the morphobiological features of fungi, updating their taxonomy and nomenclature, shows the role of fungi in nature and the development of fungal infections in humans and animals, structured information on the classification of mycoses and their pathogens. The latest information is also provided on the pharmacological properties of the main currently existing antifungal drugs, the mechanisms of formation of resistance to them in fungi, in a comparative aspect with other groups of antimycotic drugs, the prospects of azoles and their derivatives as new fungicidal drugs and disinfectants are shown. Literature studies have shown that 1,2,4-triazole derivatives have a wide range of antifungal activity, which extends to other types of activity.Conclusion. It was noted that the significant prospects of triazoles are due, among other things, to the fungicidal effect on resistant strains of fungi-pathogens of human and animal infections. The advantage of the new derivatives is the low level of concentrations suppressing fungi, low cytotoxicity, which allows them to be used for intravenous administration in the future. Updating information on the effectiveness of new antifungal compounds will help researchers systematize knowledge about the properties of azoles, which can contribute to the search and development of new potential candidates for antifungal drugs with high efficiency and selectivity, and contribute to the formation of new research directions for the search for effective means of combating mycoses in various fields of human activity.
