Search for new drugs for the treatment of HIV infections among nucleosides and nucleotides. II

Kraevskii, A. A.

doi:10.1007/bf00773194

Cited by 2 publications

(1 citation statement)

References 60 publications

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“…Nucleoside analogs containing nicotinic acid residues are considered as an alternative to the prodrug forms discussed above [ 112 ]. The introduction of nicotinic acid residues into the carbohydrate unit of the nucleoside makes it possible to reduce the toxicity of the drug, increase its stability in the cell, prolong its life time in the bloodstream, and also provide permeability through the blood–brain barrier [ 113 , 114 ].…”

Section: Mechanism Of Anti-viral Action Of Nucleosidesmentioning

confidence: 99%

Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

et al. 2021

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The emergence of new viruses and resistant strains of pathogenic microorganisms has become a powerful stimulus in the search for new drugs. Nucleosides are a promising class of natural compounds, and more than a hundred drugs have already been created based on them, including antiviral, antibacterial and antitumor agents. The review considers the structural and functional features and mechanisms of action of known nucleoside analogs with antiviral, antibacterial or antiprotozoal activity. Particular attention is paid to the mechanisms that determine the antiviral effect of nucleoside analogs containing hydrophobic fragments. Depending on the structure and position of the hydrophobic substituent, such nucleosides can either block the process of penetration of viruses into cells or inhibit the stage of genome replication. The mechanisms of inhibition of viral enzymes by compounds of nucleoside and non-nucleoside nature have been compared. The stages of creation of antiparasitic drugs, which are based on the peculiarities of metabolic transformations of nucleosides in humans body and parasites, have been considered. A new approach to the creation of drugs is described, based on the use of prodrugs of modified nucleosides, which, as a result of metabolic processes, are converted into an effective drug directly in the target organ or tissue. This strategy makes it possible to reduce the general toxicity of the drug to humans and to increase the effectiveness of its action on cells infected by the virus.

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Section: Mechanism Of Anti-viral Action Of Nucleosidesmentioning

confidence: 99%

Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

et al. 2021

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Synthesis of 2', 3'-didehydro-2', 3'-dideoxyuridine with following addition of triphenylphosphonium iodides

1996

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Институт молекулярной биологии и генетики НАН Украины 252143, Киев, ул. Академика Заболотного, 150 При изучении реакций 5'-бензоил-02,2'-циклоуридина с трифенилйодфосфоний йодидом, а затем с участием имидазола иои его производных было показано, что процесс идет через стадии образования сначала 2'-йод-2'-дезокси-и далее 2',3'дшюд-2',3'-дидезоксиуридинов. Последний в силу своей нестабильности превращается в соответствующий 2', 3'-дидегидро-2', З'-дидезоксинуклеозид.

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Search for new drugs for the treatment of HIV infections among nucleosides and nucleotides. II

Cited by 2 publications

References 60 publications

Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

Antiviral and Antimicrobial Nucleoside Derivatives: Structural Features and Mechanisms of Action

Synthesis of 2', 3'-didehydro-2', 3'-dideoxyuridine with following addition of triphenylphosphonium iodides

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