2003
DOI: 10.1016/j.jchromb.2003.08.008
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Search for peptidic “middle molecules” in uremic sera: isolation and chemical identification of fibrinogen fragments

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Cited by 26 publications
(21 citation statements)
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“…Since these fragments were not present in normal serum, they inferred that these fragments are a part of MM toxins and wondered ''whether these fragments contribute to the platelet dysfunction in uremia.'' In this study, we have documented that FF isolated from uremic plasma inhibit platelet function and in view of the observations reported by Kaplan et al [9], these fragments could play a role, either alone or in concert with other factors, in causing platelet dysfunction in uremic patients.…”
Section: Discussionsupporting
confidence: 67%
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“…Since these fragments were not present in normal serum, they inferred that these fragments are a part of MM toxins and wondered ''whether these fragments contribute to the platelet dysfunction in uremia.'' In this study, we have documented that FF isolated from uremic plasma inhibit platelet function and in view of the observations reported by Kaplan et al [9], these fragments could play a role, either alone or in concert with other factors, in causing platelet dysfunction in uremic patients.…”
Section: Discussionsupporting
confidence: 67%
“…For example, urea [27,28], guanidinosuccinic acid [29], phenols [30], and uremic MM [31] have been incriminated as factors that may cause impaired platelet function. In an exhaustive study in search of peptidic MM, Kaplan et al [9] identified several fragments of fibrinogen in uremic serum. Since these fragments were not present in normal serum, they inferred that these fragments are a part of MM toxins and wondered ''whether these fragments contribute to the platelet dysfunction in uremia.''…”
Section: Discussionmentioning
confidence: 99%
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“…Peptides were analyzed with 60 ns delayed extaction. Sequential Edman degradation of peptides purified by reverse-phase hplc was performed using a Procise 492 sequencer (Applied Biosystems, Foster City CA) as previously described [19].…”
Section: Methodsmentioning
confidence: 99%