Waste management is one of the major challenges of urban management in Sub Saharan African countries. The current difficulties in the management of solid waste are the result of poor mastering of concepts, approaches, and techniques. This paper aims to study the Greenhouse gas reduction and cost-benefit through improving municipal solid waste management in Ouagadougou. Since the site location is important for collection optimization, the paper was focused on the research of the technique to achieve this goal with two identified methods, the gravity method and the Quantitative System for Business software (WinQSB). The result showed that both methods got the same coordinate system (12.36943601;-1.513841578) which corresponds to street 3.22, Dapoya, Ouagadougou, Burkina Faso. The new site offers more benefits, especially in terms of cost reduction as well as greenhouse gas reduction. For example, ten million FCFA or twenty thousand 20,000 USD a year could be saved up.CO 2 emissions in the transport sector pose a key problem along with particle and NOx emissions. Also, 30 m 3 of gasoline is needed per week per truck to transport urban waste, which is released around 3,801.6 Kg of CO 2 per year by using an old transfer station. By considering the new transfer station because of the proximity of collection points, around 2,500.8 Kg of CO 2 per year is released which is less than CO 2 released in the old station.