We perform comparative studies for four types of the two Higgs Doublet Models (2HDMs) under the precision measurements of the Standard Model (SM) Higgs observables at the proposed Higgs factories. We explore the discovery potential based on the hypothetical deviations in the precision data for the 2HDMs up to one-loop level. We find 5σ observability from the χ2 fitting in a significant theory parameter space at future Higgs factories. For the Type-I 2HDM, regions with cos(β − α) ≲ −0.1 or cos(β − α) ≳ 0.08 are discoverable at more than 5σ level. For the other three types of 2HDMs, the 5σ region is even bigger: | cos(β − α)| ≳ 0.02 for tan β ∼ 1. At small and large values of tan β, the region in cos(β − α) is further tightened. We examine the extent to which the different 2HDM theories may be distinguishable from one to the other at the 95% Confidence Level with four benchmark points as case studies. We show that a large part of the parameter space of the other types of 2HDMs can be distinguished from the benchmark points of the target model. The impacts of loop corrections are found to be significant in certain parameter regions.