Searching for Silphium: An Updated Review

Abstract

From luxury spice to medical cure-all, silphium was a product coveted throughout the ancient world and occupied an essential place in the export economy of ancient Cyrene. The mysterious extinction of the silphium plant in the 1st century CE leaves us with little evidence as to the exact nature of this important agricultural product. In this paper, an historical background on the kingdom of Cyrene is provided, evidence for the nature of the silphium plant is reviewed, how and why it was consumed and traded is discussed. Possible causes of extinction are considered in the context of plant genetics, biometrics, and soil geochemistry. Next, we demonstrate how modern medical studies conducted on possible living relatives can inform us about claims made by ancient authors as to the medical uses of the silphium plant, including its use as a contraceptive and abortifacient. Finally, methods for recovering silphium are explored. We show how underwater archaeology and the search for ancient shipwrecks off the northern coast of Libya may offer our best chance for the recovery of botanical remains of ancient silphium, and how ancient DNA may be able to establish the genetic makeup of this elusive plant.

β-cell intrinsic dynamics rather than gap junction structure dictates subpopulations in the islet functional network

“…Raw microscopy imaging data is available on the EMBL-EBI-supported BioImage Archive. Analysis code, model code, and simulated data is available via GitHub at https://github.com/jenniferkbriggs/Functional_and_Structural_Networks (copy archived at Briggs, 2023 ).…”