Searching for the fountain of autophagy-dependent youth

Klionsky, Daniel J.; Bergamini, Ettore

doi:10.4161/auto.20788

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Antiaging diet restriction is known to be the most effective intervention that retards aging and extends lifespan and health span. Effects are known to involve the activation of macroautophagy, a cell repair mechanism [40] that can be intensified by the administration of antilipolytic agents during fasting to safely improve cell housekeeping and boost the benefits of caloric restriction [41]. Physical exercise, which is available at low cost and largely free of adverse effects, is another powerful antiaging strategy that can influence, at least partly, most of the hallmarks of biological aging [42].…”

Section: Alzheimer's Disease: Treatment or Prevention Strategies?mentioning

confidence: 99%

“…Good maintenance will be finalized later, thanks to a good meal. If needed, benefit might be magnified by taking a pill of an antilipolytic drug on the time of fasting [41]. Benefits of protocol might be monitored noninvasively by the assay of the urinary excretion of 8-hydroxy-2′-deoxyguanosine, a recently recommended biomarker for monitoring oxidative status over time [68].…”

Section: The "Train Body and Brain" Protocol For A Primary Interventimentioning

confidence: 99%

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Primary Prevention of Alzheimer’s Disease (AD)

Bergamini¹,

Cavallini²

2019

Geriatric Medicine and Gerontology

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Alzheimer dementia (AD) is a complex, aging-associated disease whose effects on the brain (an organ made up by nonreplaceable cells) are devastating. Disease is not curable, but progress in pathobiology shows that intervention on aging can make primary prevention of AD feasible. According to the amyloid-cascade hypothesis, mechanisms of AD include: an age-related alteration of free radical metabolism in membranes, leading to a higher yield in the toxic Aβ1-42 peptide and an overwhelming impact on the weaker repair mechanisms of the aging cells. The proposed intervention on aging with anti-AD effects includes a daily assumption of antioxidants (red wine polyphenols enriched with resveratrol), a reinforcement of membrane antioxidant defenses by the assumption of polyunsaturated fatty acids at the first meal after fasting, and an enhancement of cell repair function (at the proteasome and autophagy level by an intermittent feeding regimen and physical exercise plus the assumption of antilipolytic agents during time of fasting). The beneficial effects of diet and physical activity on the endogenous production of protective nerve growth factors are magnified by an enriched environment. Treatment has already been started on healthy individuals at a higher risk of AD in the city of Volterra.

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Section: Alzheimer's Disease: Treatment or Prevention Strategies?mentioning

confidence: 99%

Section: The "Train Body and Brain" Protocol For A Primary Interventimentioning

confidence: 99%

Primary Prevention of Alzheimer’s Disease (AD)

Bergamini¹,

Cavallini²

2019

Geriatric Medicine and Gerontology

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Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism

Dahabieh

Pietro

Jangal

et al. 2018

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Acipimox inhibits human carbonic anhydrases

Mori

Supuran

2022

Journal of Enzyme Inhibition and Medicinal Chemistry

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Acipimox, a nicotinic acid derivative in clinical use for the treatment of hyperlipidaemia, incorporates a free carboxylic acid and an N-oxide moiety, functionalities known to interact with the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and inhibit its activity. Herein we report that acipimox acts as a low micromolar CA inhibitor (CAI) against most human (h) isoforms possessing catalytic activity, hCA I – XIV. By using computational techniques (docking and molecular dynamics simulations), we propose that acipimox coordinates through its carboxylate group to the zinc ion from the enzyme active site cavity, whereas the N-oxide group is hydrogen-bonded to the proton shuttle His residue in some isoforms (hCA I) or to active site Thr or Gln residues in other isoforms (hCA II, III, IV, VII, etc). As some CA isoforms are involved in lipogenesis, these data may be useful for the design of more effective CAIs with antiobesity activity.

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Searching for the fountain of autophagy-dependent youth

Cited by 3 publications

References 20 publications

Primary Prevention of Alzheimer’s Disease (AD)

Primary Prevention of Alzheimer’s Disease (AD)

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism

Acipimox inhibits human carbonic anhydrases

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