Seasonal Allergic Rhinitis

Leung, Alexander K. C.; Hon, Kam‐Lun Ellis

doi:10.2174/187221308786241965

Cited by 15 publications

(3 citation statements)

References 81 publications

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“…Pharmacotherapy of AR is multivariate, and many interactive pathways are involved in pathophysiology of AR. The different class of drugs such as antihistamines, corticosteroids, mast cell stabilizers, decongestants, antileukotrienes and anticholinergics have been used (Leung and Hon, ). However, these drugs are effective only for short period (few weeks).…”

Section: Introductionmentioning

confidence: 99%

Anti-allergic Effect of Intranasal Administration of Type-A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice

Aswar¹,

Kandhare

Mohan

et al. 2014

Phytother. Res.

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The objective of the present work was to evaluate anti-allergic effects of intranasal administration of type-A procynidines polyphenols (TAPP) based standardized hydroalcoholic extract of Cinnamomum zeylanicum bark (TAPP-CZ) in ovalbumin (OVA)-induced experimental allergic rhinitis (AR) in BALB/c mice. Sixty male BALB/c mice were divided into six groups of ten each (G1-G6). The mice from G1 were nonsensitized and maintained as normal group. Remaining mice (G2-G6) were sensitized with OVA (500 μL solution, intraperitoneal) on alternate days for 13 days and had twice daily intranasal treatment from day 14-21 as follows: G2 (AR control) received saline, G3 (positive control, XLY) received xylometazoline (0.5 mg/mL, 20 μL/nostril) and G4-G6 received TAPP-CZ (3, 10 and 30 µg/kg in nostril), respectively. On day 21, mice were challenged with OVA (5 μL/nostril, 5% solution) and assessments (nasal signs, biochemical and histopathological) were performed. Treatment with TAPP-CZ (10 and 30 µg/kg in nostril) showed significant attenuation in OVA-induced alterations of the nasal (number of nasal rubbing and sneezing), biochemical markers (serum IgE and histamine), haematological, morphological (relative organ weight of spleen and lung) and histopathological (nasal mucosa and spleen) parameters. In conclusion, TAPP-CZ showed anti-allergic efficacy in animal model of AR.

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Section: Introductionmentioning

confidence: 99%

Anti-allergic Effect of Intranasal Administration of Type-A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice

Aswar¹,

Kandhare

Mohan

et al. 2014

Phytother. Res.

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“…Oral antihistamines are often the first line treatment administered for SAR [2]. However, as SAR symptoms result from an interaction between inhaled allergens and IgE antibodies on mast cells located in the upper airway [3], it may be possible to achieve faster symptom relief through direct local delivery of a medication to the nasal tissues.…”

Section: Introductionmentioning

confidence: 99%

A four-way, double-blind, randomized, placebo controlled study to determine the efficacy and speed of azelastine nasal spray, versus loratadine, and cetirizine in adult subjects with allergen-induced seasonal allergic rhinitis

Ellis

Zhu

Walker

et al. 2013

All Asth Clin Immun

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BackgroundAzelastine has been shown to be effective against seasonal allergic rhinitis (SAR). The Environmental Exposure Unit (EEU) is a validated model of experimental SAR. The objective of this double-blind, four-way crossover study was to evaluate the onset of action of azelastine nasal spray, versus the oral antihistamines loratadine 10 mg and cetirizine 10 mg in the relief of the symptoms of SAR.Methods70 participants, aged 18-65, were randomized to receive azelastine nasal spray, cetirizine, loratadine, or placebo after controlled ragweed pollen exposure in the EEU. Symptoms were evaluated using the total nasal symptom score (TNSS). The primary efficacy parameter was the onset of action as measured by the change from baseline in TNSS.ResultsAzelastine displayed a statistically significant improvement in TNSS compared with placebo at all time points from 15 minutes through 6 hours post dose. Azelastine, cetirizine, and loratadine reduced TNSS compared to placebo with an onset of action of 15 (p < 0.001), 60 (p = 0.015), and 75 (p = 0.034) minutes, respectively. The overall assessment of efficacy was rated as good or very good by 46% of the participants for azelastine, 51% of the participants for cetirizine, and 30% of the participants for loratadine compared to 18% of the participants for placebo.ConclusionsAzelastine’s onset of action for symptom relief was faster than that of cetirizine and loratadine. The overall participant satisfaction in treatment with azelastine is comparable to cetirizine and statistically superior to loratadine. These results suggest that azelastine may be preferential to oral antihistamines for the rapid relief of SAR symptoms.

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“…[ 11 ] Recently, interest in alternative drugs or compounds has been increasing to find a better treatment that can reduce side effect. [ 12 13 ]…”

Section: Introductionmentioning

confidence: 99%

Peimine inhibits the production of proinflammatory cytokines through regulation of the phosphorylation of NF-κB and MAPKs in HMC-1 Cells

et al. 2017

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Background:Peimine is a major biologically active component of Fritillaria ussuriensis. Peimine was investigated in chronic inflammation response, but it has not been studied in mast cell-related immediate allergic reaction. The present study aimed to evaluate anti-allergic effect of peimine in human mast cell (HMC-1).Materials and Methods:The effect of peimine on cell viability was measured by MTS assay in HMC-1. Histamine release was investigated in rat peritoneal mast cells (RPMCs). Interleukin (IL)-6, IL-8, and tumor necrosis factor-α (TNF-α) expressions were measured by ELISA assay and reverse transcription-polymerase chain reaction. Mitogen-activated protein kinases (MAPKs) and nuclear factor-kappaB (NF-κB) were examined by Western blot. Passive cutaneous anaphylaxis (PCA) reactions were evaluated using Sprague-Dawley (SD) rats.Results:Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-α. Moreover, peimine reduced MAPKs phosphorylation and the nuclear NF-κB expression in PMACI-induced HMC-1. Peimine decreased PCA reactions in rats as well.Conclusion:Our study proved that peimine might be suitable for the treatment of mast cell-derived allergic inflammatory reactions.SUMMARY Peimine inhibited the production of pro-inflammatory cytokines, such as IL-6, IL-8, and TNF-αPeimine reduced MAPKs phosphorylation and the nuclear NF-κB expression in PMACI-induced HMC-1Peimine decreased PCA reactions in ratsPeimine has anti-allergic effect through regulation of pro-inflammatory mechanism on mast cell. Abbreviations used: HMC-1: Human mast cell, MTS: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, RPMCs: Rat peritoneal mast cells. IL-6: Interleukin 6, IL-8: Interleukin 8, TNF-α: Tumor necrosis factor-α, MAPKs: Mitogen-activated protein kinases; NF-κB: Nuclear factor-kappaB, PCA: Passive cutaneous anaphylaxis reactions, SD: Sprague-Dawley.

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Seasonal Allergic Rhinitis

Cited by 15 publications

References 81 publications

Anti-allergic Effect of Intranasal Administration of Type-A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice

Anti-allergic Effect of Intranasal Administration of Type-A Procyanidin Polyphenols Based Standardized Extract of Cinnamon Bark in Ovalbumin Sensitized BALB/c Mice

A four-way, double-blind, randomized, placebo controlled study to determine the efficacy and speed of azelastine nasal spray, versus loratadine, and cetirizine in adult subjects with allergen-induced seasonal allergic rhinitis

Peimine inhibits the production of proinflammatory cytokines through regulation of the phosphorylation of NF-κB and MAPKs in HMC-1 Cells

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