Seasonal and day of the week variations of perforated appendicitis in US children

Deng, Yi; Chang, David C.; Zhang, Yiyi; Webb, Jennifer; Gabre-Kidan, Alodia; Abdullah, Fizan

doi:10.1007/s00383-010-2628-z

Cited by 48 publications

(41 citation statements)

References 24 publications

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“…Instead, there are reports indicative of a primary infectious event [11], and one study reported on appendicitis appearing in clusters [12]. There are also reports of a seasonal variation of the incidence of acute appendicitis [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the microbiome in children’s appendicitis

Salö

Marungruang

Roth

et al. 2016

Int J Colorectal Dis

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Background/aimThe role of the microbiome has been widely discussed in the etiology of appendicitis. The primary aim was to evaluate the microbiome in the normal appendix and in appendicitis specifically divided into the three clinically and histopathologically defined grades of inflammation. Secondary aims were to examine whether there were any microbiome differences between proximal and distal appendices, and relate the microbiome with histopathological findings.MethodsA prospective pilot study was conducted of children undergoing appendectomy for appendicitis. The diagnosis was based on histopathological analysis. Children with incidental appendectomy were used as controls. The proximal and distal mucosa from the appendices were analyzed with 16S rRNA gene sequencing.ResultsA total of 22 children, 3 controls and 19 appendicitis patients; 11 phlegmonous, 4 gangrenous, and 4 perforated appendices, were prospectively included. The amount of Fusobacterium increased and Bacteroides decreased in phlegmonous and perforated appendicitis compared to controls, but statistical significance was not reached, and this pattern was not seen in gangrenous appendicitis. No relation could be seen between different bacteria and the grade of inflammation, and there was a wide variation of abundances at phylum, genus, and species level within every specific group of patients. Further, no significant differences could be detected when comparing the microbiome in proximal and distal mucosa, which may be because the study was underpowered. A trend with more abundance of Fusobacteria in the distal mucosa was seen in appendicitis patients with obstruction (25 and 13 %, respectively, p = 0.06).ConclusionThe pattern of microbiome differed not only between groups, but also within groups. However, no statistically significant differences could be found in the microbiome between groups or clinical conditions. No correlation between a specific bacteria and grade of inflammation was found. In the vast majority of cases of appendicitis, changes in microbiome do not seem to be the primary event. Since there seem to be differences in microbiome patterns depending on the sample site, the exact localization of biopsy sampling must be described in future studies.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the microbiome in children’s appendicitis

Salö

Marungruang

Roth

et al. 2016

Int J Colorectal Dis

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“…Acute Appendicitis (AA) is the most commonly encountered disease in emergency clinics, with about 250,000 cases of appendicitis reported in The United States and 40,000 in England each year (Deng et al, 2010;Simpson et al, 2008). The key form of treatment for the disease is surgery and the mortality, morbidity, and economic cost ratio rise the longer it remains untreated.…”

Section: Introductionmentioning

confidence: 99%

Demographic and Epidemiologic Features of Acute Appendicitis

Sulu¹

2012

Appendicitis - A Collection of Essays From Around the World

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“…Çalışmalarda AA yaz ayların-da sık görülmekte iken, bir kısmında da kış aylarında daha sık görülmektedir. [2,13,15,17] Çalışmamızda AA sonbahar ve ilkbahar mevsiminde daha sık görülmekle birlikte istatistiki fark gör-medik. Birçok çalışmada PA kış ve sonbahar aylarında daha sık bildirilmiştir.…”

Section: Discussionunclassified

“…Çocuk-lardaki en sık cerrahi karın ağrısı nedenidir. [1,2] İnsanların %7'si hayatları boyunca apandisit nedeni ile ameliyat edilir. Bununla birlikte doğru tanı %72-94 oranında kalmaktadır.…”

Section: Introductionunclassified

Analsis of the risk factors for child appendicitis

Yıldız

Bozdağ

Erkorkmaz

et al. 2013

Ulus Travma Acil Cerrahi Derg

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ÖZET AMAÇ: Apandisit çocuklardaki en sık cerrahi karın ağrısı nedenidir. Biz bu çalışmada apandektomilerin histopatolojileri üzerine yaş, cinsiyet, mevsim ve ailesel faktörlerin etkisini araştırdık. GEREÇ VE YÖNTEM:Akut apandisit nedeni ile Eylül 2009-2011 yılları arasında ameliyat edilen 588 hasta çalışmaya alındı. Hastalar histopatolojik bulgularına göre akut, perfore ve negatif apandektomi olarak üç gruba ayrıldı. Bu gruplar üzerine yaş, cinsiyet, mevsim ve ailesel faktörlerin etkinliği araştırıldı. BULGULAR:Hastaların ortalama yaşı 11.8±3.26 yıl (dağılım, 1-16 yıl) idi. Hastaların analizinde 10 yaşından sonra apandisit 2.41 kez sık görüldü. Erkeklerde apandisit kızlara göre 4.63 kez daha sık bulundu. Negatif apendektomi ile 10 yaşından sonra daha sık karşılaşıldı. Aile hikayesi ve mevsimlerin apandisit üzerine etkisi oransal olarak saptandı fakat bu etki anlamlı değildi (p>0.05). SONUÇ:Apandisit cerrahisi planlarken yaş ve cinsiyet dikkate alınmalıdır. Çünkü doğru tanı yaş ve cinsiyet ile ilişkilidir. Ayrıca apandisit histopatolojisi ailesel ve çevresel faktörlerden etkilenir.

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Seasonal and day of the week variations of perforated appendicitis in US children

Abstract: Perforated appendicitis was more likely to present on Mondays in US children. Although appendicitis is most common in summer months, rates of perforated appendicitis were highest in fall and winter.

Cited by 48 publications

References 24 publications

Evaluation of the microbiome in children’s appendicitis

Evaluation of the microbiome in children’s appendicitis

Demographic and Epidemiologic Features of Acute Appendicitis

Analsis of the risk factors for child appendicitis

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