Seasonal aspects of sarcomatous neoplasia in Mya arenaria (soft-shell clam) from Long Island Sound

Environmental limits for survival of sarcoma cells from the soft-shell clam Mya arenaria

“…In earller studies, this disease in soft-shell clams was called hematopoietic neoplasia on the unproven assumption that the cell origin was hemocytes (Farley et al 1986, Farley 1989). This type of neoplasm previously had been found in clams from numerous sites in New England, USA (Barry & Yevich 1975, Yevich & Barszcz 1976, Brown et al 1977, Cooper et al 1982, Reinisch et al 1984, Brousseau 1987.…”

Assessment of haemic neoplasia in different soft shell clam Mya arenaria populations from eastern Canada by flow cytometry

“…HN diagnosis is often based on hematocytology, coupled or not with histological tissue examination (Brousseau, 1987;Brousseau and Baglivo, 1991a;da Silva et al, 2005;Dungan et al, 2002;Elston et al, 1988;McGladdery et al, 2001;Villalba et al, 2001). Haemolymph-screening techniques enable distinction of neoplastic cells based on their morphology.…”

Disseminated neoplasia in blue mussels, Mytilus galloprovincialis, from the Black Sea, Romania

“…The condition is characterized by proliferation of anaplastic circulating cells with relatively large nuclei, a high nucleus-to-cytoplasm ratio and frequent presence of mitosis (Elston et al 1992). The condition has also been called sarcomatoid proliferative disease (Farley 1969), proliferative atypical hemocytic condition (Lowe and Moore 1978), epizootic sarcoma (Farley et al 1986), sarcomatous neoplasia (Brousseau 1987), transmissible sarcoma (Farley et al 1991) and systemic neoplasia (Moore et al 1991). Regardless the nomenclature, this disorder, apparently of hemocytic origin, is distinguishable from another group of bivalve neoplasia, germinomas (reviewed by Peters et al, 1994) even when these cases become invasive and systemic.…”