Abstract.We develop an algorithm to compute pCO 2 in the Scotian Shelf region (NW Atlantic) from satellite-based estimates of chlorophyll-a concentration, sea-surface temperature, and observed wind speed. This algorithm is based on a high-resolution time-series of pCO 2 observations from an autonomous mooring. There is a gradient in the air-sea CO 2 flux between the northeastern Cabot Strait region which acts as a net sink of CO 2 with an annual uptake of 0.50 to 1.00 mol C m −2 yr −1 , and the southwestern Gulf of Maine region which acts as a source ranging from −0.80 to −2.50 mol C m −2 yr −1 . There is a decline, or a negative trend, in the air-sea pCO 2 gradient of 23 µatm over the decade, which can be explained by a cooling of 1.3 • C over the same period. Regional conditions govern spatial, seasonal, and interannual variability on the Scotian Shelf, while multi-annual trends appear to be influenced by larger scale processes.