Seasonal difference in thermoregulatory responses to opiates in a mammalian hibernator

Wang, Lawrence C.H.; Lee, T.F.; Jourdan, M.L.

doi:10.1016/0091-3057(87)90167-5

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Arousal From Hibernation1

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1988

2022

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Cited by 19 publications

(2 citation statements)

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“…Many functional roles have been at tributed to these neural systems. Among the suggested functions are the cerebral adapta tion to hibernation [1], Endogenous opioids such as met-enkephalin seem to act by sup pression of neural metabolic activity in sev eral ways, for example by inhibiting the up take of Ca++ into nerve terminals. Thereby, they may block transmitter release [2].…”

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confidence: 99%

Endogenous Opioids May Protect the Perinatal Brain in Hypoxia

Hc¹,

Wa²,

Jm³

1989

Dev Pharmacol Ther

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Endogenous opioids are released in great amounts in perinatal asphyxia. The role of this release has been unclear. In a study of cerebral blood flow and oxygen metabolism in 5 hypoxic newborn lambs, naloxone blocking of opioid receptors resulted in a proportional increase in telencephalic cerebral blood flow and oxygen metabolism. It is suggested that endogenous opioid release protects the neonatal brain in hypoxia by diminishing the cerebral metabolic rate of oxygen.

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confidence: 99%

Endogenous Opioids May Protect the Perinatal Brain in Hypoxia

Hc¹,

Wa²,

Jm³

1989

Dev Pharmacol Ther

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“…Physiological activities are restored to near-normal levels. Rewarming of the body is initiated by non-shivering thermogenesis in brown adipose tissue (BAT) but after the Tb rises to 15-20°C shivering thermogenesis in skeletal muscle also begins and adds to the rewarming (Wang et al, 1987). Why these periodic arousals occur is still not clear but several hypotheses have been proposed.…”

Section: Arousal From Hibernationmentioning

confidence: 99%