Seasonal differences in the onset of the EBV-positive and -negative forms of paediatric Hodgkin's lymphoma

Abstract

In this study, we have shown that there are seasonal differences in the onset of the (Epstein -Barr virus) EBV-positive and -negative forms of paediatric Hodgkin's lymphoma (HL). This suggests aetiological differences between the two forms of this disease. EBVpositive HL might be a rare consequence of primary EBV infection.

Phenotype and frequency of Epstein–Barr virus‐infected cells in pretreatment blood samples from patients with Hodgkin lymphoma

“…Whether this reflects a non-specific increase in EBV replication as a result of infection or whether it represents an antigen-driven response remains to be determined; however, the data suggest that infections may play some role in the pathogenesis of EBVassociated germinal centre lymphomas. Consistent with this idea, HL incidence shows a curious seasonality (Newell et al, 1985;Douglas et al, 1996;Reiman et al, 2003).…”

Detection of the Epstein–Barr virus, Human Bocavirus and novel KI and KU polyomaviruses in adenotonsillar tissues

“…Lossius et al reported that there was a seasonal fluctuation of infectious mononucleosis with a larger proportion of the individuals reporting infectious mononucleosis during spring compared to autumn in their study which they investigated relationship of EBV and multiple sclerosis [11]. A peak incidence during June to August was reported among for EBV-positive pediatric Hodgkin's lymphoma patients in the other study [12]. It was surprising for us to identify EBV peak incidence in the summer and autumn seasons in adenotonsillar diseases.…”

Co-infection withHelicobacter pyloriand Epstein–Barr virus in benign upper digestive diseases: An endoscopic and serologic pilot study

“…EBV was also more frequent in duodenal ulcer patients than in GERD (p ¼ 0.046) and functional dyspepsia cases (0.041), although the significance is only marginal (Figure 2). Genital, oral and mucocutaneous ulcers 3,4 Gastric lymphoepithelial carcinoma 5 Burkitt lymphoma 5 B-cell, NK/T cell tumors 5 Paediatric Hodgkin's lymphoma 6 Type 1 diabetes mellitus? 7 Co-infection with H. pylori and EBV was found in 60.0% of duodenal ulcer patients, 18.18% of GERD and 12.90% of functional dyspepsia cases, the differences being highly significant (duodenal ulcer versus GERD p ¼ 0.000010, duodenal ulcer versus functional dyspepsia p ¼ 0.00014).…”

“…Infection with this herpesvirus can lead to a wide range of acute and chronic, benign or malignant conditions as listed in Table 1. [1][2][3][4][5][6][7] It was recently shown that a certain number of gastric carcinomas are associated with EBV infection. The presence of the virus in the lymphocytes around gastric tumours was first demonstrated in 1992.…”