Seasonal distribution of initial diagnosis and clinical recrudescence of eosinophilic esophagitis: a systematic review and meta‐analysis

Abstract

This systematic review found no significant variations in the seasonal distribution of either the diagnosis or clinical recrudescence of EoE throughout the year.

Incidence of eosinophilic esophagitis in the Netherlands continues to rise: 20‐year results from a nationwide pathology database

“…In our cohort we did not observe seasonal variation in the number of newly diagnosed cases of EoE. This finding is in keeping with a recently published meta‐analysis in which they also failed to demonstrate seasonal variation in either the initial diagnosis or clinical recrudescence of EoE . However, results should be interpreted with caution as there may have been a substantial gap between the onset of symptoms and the diagnostic endoscopy.…”

“…This finding is in keeping with a recently published meta-analysis in which they also failed to demonstrate seasonal variation in either the initial diagnosis or clinical recrudescence of EoE. 23 However, results should be interpreted with caution as there may have been a substantial gap between the onset of symptoms and the diagnostic endoscopy. Nevertheless, based on our results and the convincing previously published data we believe that aeroallergen exposure or ingestion of seasonal fruits have only a limited role in inducing EoE.…”

Airborne and food sensitization patterns in children and adults with eosinophilic esophagitis

“…Its pathophysiology is yet unknown but emerging evidence indicates that airborne and food hypersensitivity may play a key role . Some reports show a seasonal variation of incidence of EoE, suggesting a role for airborne allergens in the clinical course of EoE, but the literature remains unclear on this point . Studies have shown that 68% of pediatric EoE patients have a history of allergic disorders such as allergic rhinitis (AR), asthma, atopic dermatitis, and food allergy (FA), and that allergy testing‐directed diets in children with EoE achieved 69% resolution of the symptoms .…”

Editorial: elemental diets for eosinophilic oesophagitis

“…For example, in animal models, EoE can be induced without direct oesophageal stimulation such as through skin and lung allergen exposure . In patients, eosinophilic oesophagitis may flare during the seasons with increased airway allergen exposure . Nevertheless, the oesophagus is considered the primary site of activation by food antigen exposure in EoE based on three important pieces of data: (i) Food antigens can be seen in the oesophageal mucosa .…”