Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-like growth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus)

Xie, Wenlian; Tang, Zeqi; Guo, Yuanyuan; Zhang, Chunjiao; Zhang, Haolin; Han, Yingying; Yuan, Zhengrong; Wang, Qiang

doi:10.1016/j.ygcen.2019.05.014

Cited by 10 publications

(2 citation statements)

References 51 publications

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“…These findings align with previous reports indicating that PRL is integral to both cellular proliferation and differentiation during ovarian development, 28 suggesting a heightened cell proliferative rate during the breeding season as compared to the non-breeding season. 36 These results further support the notion that the ovaries of seasonally breeding mammals undergo morphological changes, including increased ovarian mass, during the breeding season, with PRL playing a critical role in ovarian growth and development. 21 , 37 …”

Section: Discussionsupporting

confidence: 77%

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt)

Gao,

Xie,

et al. 2023

Eur J Histochem

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Prolactin (PRL) is a hormone crucial for normal reproduction, functioning as an autocrine, paracrine, and endocrine factor. This study aimed to examine the immunolocalization and expression patterns of PRL, prolactin receptor (PRLR), and signal transducer and activator of transcription 5 (STAT5) in the ovaries of wild ground squirrels during both breeding and non-breeding periods. Significant seasonal variations were observed in ovarian weights, with higher values during the breeding season and relatively lower values during the nonbreeding season. PRL, PRLR, STAT5, and p-STAT5 were immunolocalized in granulosa cells and luteal cells during the breeding season, whereas they were exclusively found in granulosa cells during the non-breeding season. The mRNA expression levels of Prl, Prlr, and Stat5 were increased in ovarian tissues during the breeding season compared to the non-breeding season. Moreover, the mean mRNA levels of Prl, Prlr, and Stat5 exhibited a positive correlation with ovarian weights. Both circulating PRL and ovarian PRL concentrations were significantly elevated during the breeding season. Additionally, transcriptomic analysis of ovarian tissues revealed differentially expressed genes possibly associated with ovarian function and mammary gland development, including ovarian follicle development, steroid synthesis, and regulation of reproductive process. These findings suggest that PRL might play an essential endocrine, autocrine, or paracrine role in the regulation of seasonal changes in the ovarian functions in wild ground squirrels.

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Section: Discussionsupporting

confidence: 77%

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt)

Gao,

Xie,

et al. 2023

Eur J Histochem

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“…Numerous studies have reported that hormones regulate the reproductive state of rodents and hormonal control can manage the rodent population at the landscape scale [28]. Previously, the levels of steroid hormones in the serum and the scent glands have been consistent with the seasonal morphological variation of the scent glands, thus suggesting that steroid hormones may regulate the seasonal changes in the scent glands [29][30][31]. Several studies have reported that the main components secreted by the scent glands are esters, fatty acids, cyclic ketones and steroids, which are similar to the components of Moschus [32][33][34].…”

Section: Introductionmentioning

confidence: 98%

Mass Spectrometry Imaging of Lipids in the Scent Glands of Muskrat (Ondatra zibethicus) in Different Reproductive Statuses

Xie

Zhong

et al. 2022

Cells

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As a typical seasonal breeding animal, male muskrats have a pair of scent glands that can emit musky odor substances to attract females during the breeding period. The present study aimed to visualize the differences in the distribution of lipids in the scent glands of muskrats during their different reproductive statuses by imaging mass spectrometry and quantitative real-time PCR (qRT-PCR). The results revealed remarkable differences in the expression and spatial distribution of lipids detected in the scent glands of muskrats during the different reproductive statuses. In addition, the expression levels of lipid molecules PC (32:0) and LysoPC (16:0) were found to be significantly higher in the breeding season than in the non-breeding season. Moreover, the mRNA expression levels of lipid synthesis enzyme Pemt and Pla2g4b were higher in the breeding season than in the non-breeding season, and there were positive correlations between the expression intensities of lipid molecules and the expression levels of Pemt and Pla2g4b. The present study investigates the changes and distribution of the endogenous lipid in the scent glands of muskrats and elucidates that the seasonal changes in the lipid metabolism may affect the functions of the scent glands in muskrats.

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Vitamin D status alters genes involved in ovarian steroidogenesis in muskrat granulosa cells

Lu,

Chen,

Ramírez

et al. 2024

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Seasonal expressions of growth hormone receptor, insulin-like growth factor 1 and insulin-like growth factor 1 receptor in the scented glands of the muskrats (Ondatra zibethicus)

Cited by 10 publications

References 51 publications

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt)

Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (<em>Citellus dauricus</em> Brandt)

Mass Spectrometry Imaging of Lipids in the Scent Glands of Muskrat (Ondatra zibethicus) in Different Reproductive Statuses

Vitamin D status alters genes involved in ovarian steroidogenesis in muskrat granulosa cells

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