Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi

Angella, Aline; Salgueiro, Patrícia; Gil, Luiz Herman Soares; Vicente, José L.; Pinto, João; Ribolla, Paulo Eduardo Martins

doi:10.1186/1475-2875-13-203

Cited by 29 publications

(36 citation statements)

References 58 publications

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“…However, in Rondônia, two genetically distinct An. darlingi groups were found to be associated with different peak periods: the first in the rainy season and the second in dry environment [60].…”

Section: The Amazon Rainforest Transmission Systemmentioning

confidence: 99%

A comprehensive analysis of malaria transmission in Brazil

Carlos

Rona

Christophides

et al. 2019

Pathogens and Global Health

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Malaria remains a serious public health problem in Brazil despite a significant drop in the number of cases in the past decade. We conduct a comprehensive analysis of malaria transmission in Brazil to highlight the epidemiologically most relevant components that could help tackle the disease. We consider factors impacting on the malaria burden and transmission dynamics including the geographical occurrence of both autochthonous and imported infections, the distribution and abundance of malaria vectors and records of natural mosquito infections with Plasmodium . Our analysis identifies three discrete malaria transmission systems related to the Amazon rainforest, Atlantic rainforest and Brazilian coast, respectively. The Amazonian system accounts for 99% of all malaria cases in the country. It is largely due to autochthonous P. vivax and P. falciparum transmission by mosquitoes of the Nyssorhynchus subgenus, primarily Anopheles darlingi . Whilst P. vivax transmission is widespread, P. falciparum transmission is restricted to hotspot areas mostly in the States of Amazonas and Acre. This system is the major source of P. vivax exportation to the extra-Amazonian regions that are also affected by importation of P. falciparum from Africa. The Atlantic system comprises autochthonous P. vivax transmission typically by the bromeliad-associated mosquitoes An. cruzii and An. bellator of the Kerteszia subgenus. An. cruzii also transmits simian malaria parasites to humans. The third, widespread but geographically fragmented, system is found along the Brazilian coast and comprises P. vivax transmission mainly by An. aquasalis . We conclude that these geographically and biologically distinct malaria transmission systems require specific strategies for effective disease control.

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Section: The Amazon Rainforest Transmission Systemmentioning

confidence: 99%

A comprehensive analysis of malaria transmission in Brazil

Carlos

Rona

Christophides

et al. 2019

Pathogens and Global Health

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“…darlingi divergence at a macro-geographic scale, across its broad distribution, are biogeographic or geographic boundaries and Pleistocene environmental changes [113,119]. At a regional scale, isolation-bydistance has been shown to influence population structure [120], whereas at a micro-geographic scale, current local environmental conditions have a marked effect [113,[119][120][121][122].…”

Section: Nyssorhynchus Darlingimentioning

confidence: 99%

Malaria Transmission in South America—Present Status and Prospects for Elimination

Conn¹,

Grillet²,

Correa³

et al. 2018

Towards Malaria Elimination - A Leap Forward

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Four countries (Brazil, Colombia, Peru, and Venezuela) together contributed ~80% of the 875,000 malaria cases reported in the Latin American region (2016). During the 10-year period (2005-2015) when global malaria incidence was dramatically reduced, Brazil and Colombia were an integral part of this trend, on track to meet the mid-term 2020 goal established by the World Health Organization. In Colombia, since 2015 at the cessation of a five-year globally funded malaria program, both incidence and proportion of Plasmodium falciparum infections have increased, mainly due to the budget constraints. Similarly, despite a strong record and major recognition for reducing malaria, in 2017, Brazil has seen a resurgence of malaria cases, but no increase in the proportion of Plasmodium falciparum to P. vivax. A globally funded malaria control program in Peru from 2005 to 2010 resulted in appreciable reduction in the annual parasitic incidence down to 1/1000 by 2011-2012, but soon after, the annual malaria incidence began to rise and by the end of 2017, there were 53,261 reported cases. To add to Venezuela's political and financial woes, malaria continues to increase, such that, 300,189 cases were reported by the end of week 42, 2017. The only rational pathway to malaria elimination is sustained nation-level financial support that does not fall prey to political vicissitudes.

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“…Biting time variation of An. darlingi showed associated with seasonality [19,46] and local and ecological factor [47]. The current study collected An.…”

Section: Discussionmentioning

confidence: 94%

“…darlingi population, in a continental scale, leading to diversification within this species. However, additional genetic diversity in a minor scale has been shown for this vector by ecological differences [17,18] and seasonality [19].…”

Section: Introductionmentioning

confidence: 99%

Genetic heterogeneity in Anopheles darlingi related to biting behavior in western Amazon

Campos

Alonso

Conn

et al. 2018

Preprint

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In the Amazon Basin, Anopheles (Nyssorhynchus) darlingi is the most aggressive and effective malaria vector. In endemic areas, behavioral aspects of anopheline species such as host preference, biting time and resting location after a blood meal have a key impact on malaria transmission dynamics and transmission control strategies. An. darlingi present a variety in behavior throughout its broad distribution including blood feeding related. To investigate the genetic basis of its biting behaviors, host-seeking An. darlingi were collected in two settlements (Granada and Remansinho) in Acre, Brazil.Mosquitoes were classified by captured location (indoors or outdoors) and time (dusk or dawn). Genome-wide SNPs were used to assess the degree of genetic diversity and structure in these groups. There was evidence of genetic component of biting behavior regarding both location and time in this species. This study supports that An. darlingi blood-feeding behavior has a genetic component. Additional ecological and genomic studies may help to understand the genetic basis of mosquito behavior and address appropriate surveillance and vector control.

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Seasonal genetic partitioning in the neotropical malaria vector, Anopheles darlingi

Cited by 29 publications

References 58 publications

A comprehensive analysis of malaria transmission in Brazil

A comprehensive analysis of malaria transmission in Brazil

Malaria Transmission in South America—Present Status and Prospects for Elimination

Genetic heterogeneity in Anopheles darlingi related to biting behavior in western Amazon

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