2023
DOI: 10.3390/vaccines11081322
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Seasonal Influenza Vaccine Effectiveness in Persons Aged 15–64 Years: A Systematic Review and Meta-Analysis

Abstract: Influenza is a respiratory disease caused by the influenza virus, which is highly transmissible in humans. This paper presents a systematic review and meta-analysis of randomized controlled trials (RCTs) and test-negative designs (TNDs) to assess the vaccine effectiveness (VE) of seasonal influenza vaccines (SIVs) in humans aged 15 to 64 years. An electronic search to identify all relevant studies was performed. The outcome measure of interest was VE on laboratory-confirmed influenza (any strain). Quality asse… Show more

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Cited by 8 publications
(6 citation statements)
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“…Low vaccine protection may arise from the vaccine mismatch caused by an amino acid alteration on an epitope in the HA protein. Influenza VE is usually 40–60% when the circulating viruses are well-matched to the vaccine strain used in that season ( Martins et al, 2023 ; Osterholm et al, 2012 ; Tricco et al, 2013 ). The mismatch between the vaccine strain and the circulating viruses may substantially reduce the influenza VE ( Chon et al, 2019 ; Puig-Barbera et al, 2019 ; Rondy et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…Low vaccine protection may arise from the vaccine mismatch caused by an amino acid alteration on an epitope in the HA protein. Influenza VE is usually 40–60% when the circulating viruses are well-matched to the vaccine strain used in that season ( Martins et al, 2023 ; Osterholm et al, 2012 ; Tricco et al, 2013 ). The mismatch between the vaccine strain and the circulating viruses may substantially reduce the influenza VE ( Chon et al, 2019 ; Puig-Barbera et al, 2019 ; Rondy et al, 2018 ).…”
Section: Discussionmentioning
confidence: 99%
“…this low Ve for A(h3n2) was explained by a mismatch between the vaccine and circulating viruses [44]. indeed, the match between strains included in the vaccine and those circulating in a given season is the most important factor affecting Ve [45]. it has been calculated that Ve increases by > 25% when there is a match between the vaccine and the most prevalent circulating strains [45].…”
Section: Vaccinations Against Influenzamentioning
confidence: 99%
“…indeed, the match between strains included in the vaccine and those circulating in a given season is the most important factor affecting Ve [45]. it has been calculated that Ve increases by > 25% when there is a match between the vaccine and the most prevalent circulating strains [45]. For example, a meta-analysis on Ve in people aged 15-64 years yielded a pooled Ve on laboratory-confirmed influenza of 55.4% when there was a match between the vaccine and circulating strains vs. 39.3% otherwise [45].…”
Section: Vaccinations Against Influenzamentioning
confidence: 99%
“…Based on this data, the WHO identified the recommended influenza vaccine strains to address potential subtypes that may become prevalent in future influenza seasons. With the widespread implementation of influenza vaccines, many countries 9 12 have seen a certain reduction in influenza incidence. However, in the past decade, many regions worldwide have reported influenza outbreaks, such as Thailand 13 , Italy 14 , Taiwan 15 , and America 16 .…”
Section: Introductionmentioning
confidence: 99%