Seasonal Insulin Responses to the Oral Sugar Test in Healthy and Insulin Dysregulated Horses

Macon, Erica Lyn; Harris, Pat; Barker, Virginia D.; Adams, Amanda A.

doi:10.1016/j.jevs.2022.103945

Cited by 9 publications

(5 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary modification is a critical component in the management of hyperinsulinaemia in horses with EMS (Durham et al., 2019). Studies in ponies with ID suggested that the insulin response to oral sugars might be one of the most important predictors of laminitis risk (Meier, de Laat, et al., 2018; Meier, Reiche, et al., 2018), and reducing post‐prandial hyperinsulinaemia is therefore paramount in preventing HAL (Macon, Harris, Bailey, et al., 2022; Macon, Harris, Barker, & Adams, 2022). If the animal presents with suspected HAL, it is essential that any feeds high in non‐structural carbohydrates (e.g.…”

Section: Management Of Hyperinsulinaemiamentioning

confidence: 99%

“…Regardless of the dietary strategy implemented, the post‐prandial insulin response to diet and pasture is variable between horses and measuring pre‐ and 60–90‐min post‐ingestion (Macon, Harris, Bailey, et al., 2022; Macon, Harris, Barker, & Adams, 2022) or post‐grazing insulin is advisable to determine the individual's response to their current feed. This will inform future dietary recommendations.…”

Section: Management Of Hyperinsulinaemiamentioning

confidence: 99%

“…Season might potentially impact the repeatability of the OST, however, studies to date have yielded conflicting results (Karikoski et al., 2022; Macon, Harris, Bailey, et al., 2022; Macon, Harris, Barker, & Adams, 2022) One study from Finland found no differences in the insulin responses to the OST across seasons (Karikoski et al., 2022), however, a recent study from Kentucky found significant effects of season on insulin responses to an OST in both ID and non‐ID horses over a 2 year period (Macon, Harris, Bailey, et al., 2022; Macon, Harris, Barker, & Adams, 2022). The latter study found that basal and insulin responses to an OST were higher in spring compared to autumn and summer and winter OST responses were higher than the autumn (Macon, Harris, Bailey, et al., 2022; Macon, Harris, Barker, & Adams, 2022). Clinicians should therefore consider seasonal variation when monitoring horses using the OST.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

Sundra,

Rossi,

Rendle

et al. 2024

Equine Veterinary Education

View full text Add to dashboard Cite

SummaryLaminitis associated with hyperinsulinaemia is a significant cause of morbidity and mortality in horses with equine metabolic syndrome. The diagnosis and management of hyperinsulinaemia are therefore critical to prevent the development of laminitis. This review article aims to help primary care clinicians manage patients with hyperinsulinaemia by providing an overview of diagnostics, management strategies and new therapies that are available.

show abstract

Section: Management Of Hyperinsulinaemiamentioning

confidence: 99%

Section: Management Of Hyperinsulinaemiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

Sundra,

Rossi,

Rendle

et al. 2024

Equine Veterinary Education

View full text Add to dashboard Cite

show abstract

“…36 Horses with ID have demonstrated seasonal changes in their serum insulin concentration. 37 One study of 22 horses followed over 2 years demonstrated that horses with hyperinsulinaemia had the lowest insulin concentration (60 min post-OST) during the fall season compared to all other seasons. 38 However, a recently published study using the OST in Finnhorses to evaluate the seasonal insulin sensitivity variation over a year, suggested that the variation in the result obtained could be due to the lack of OST repeatability and not the effect of the season per se.…”

Section: Limitationsmentioning

confidence: 99%

“…The months from June to December appear to be the time of the year when the insulin response to glucose is higher, especially in pregnant mares and geldings 36 . Horses with ID have demonstrated seasonal changes in their serum insulin concentration 37 . One study of 22 horses followed over 2 years demonstrated that horses with hyperinsulinaemia had the lowest insulin concentration (60 min post‐OST) during the fall season compared to all other seasons 38 .…”

Section: Limitationsmentioning

confidence: 99%

Obesity and obesity‐associated metabolic disease conditions in Connemara ponies in Ireland

Al‐Ansari,

Golding,

Walshe

et al. 2023

Equine Veterinary Journal

View full text Add to dashboard Cite

BackgroundEquine obesity combined with insulin dysregulation (ID) is a major risk factor associated with laminitis. Some pony breeds appear to be at increased risk. However, little is known regarding the prevalence of obesity or hyperinsulinaemia as evidence of ID in Irish ponies.ObjectiveTo investigate the prevalence of obesity and associated endocrine/metabolic disease conditions in Connemara ponies and to determine if hyperinsulinaemia in these ponies could be predicted by morphometric or metabolic markers.Study designCross‐sectional study.MethodsThe study population included registered Connemara ponies recruited through public and veterinary social media posts. Ponies underwent a physical examination and information on their management and clinical history was obtained via owner questionnaire. The body condition score (BCS) was measured using the Henneke system; cresty neck score (CNS) and regionalised adiposity were also assessed. Hyperinsulinaemia was confirmed by measuring serum basal insulin concentration (BIC) or insulin concentration after an oral sugar test (OST). Blood glucose and triglyceride concentrations were measured. Characteristics of hyperinsulinaemic and insulin‐sensitive ponies were compared by logistic regression.ResultsTwo hundred ponies were included; 59 ponies (29.5%) had a BCS ≥7, 58 (29.0%) had a CNS ≥2.5 and 135 (67.5%) had regionalised adiposity; 137 (68.5%) ponies had at least one of these abnormalities. Owner‐reported history or clinical evidence of chronic laminitis was found in 92 ponies (46.0%). Hyperinsulinaemia was confirmed in 32 ponies (16.0%), including 23 of 91 (25.3%) detected by OST and 9 of 109 (8.3%) by BIC. Hypertriglyceridaemia was observed in 12 of 198 ponies (6.1%) ponies and hyperglycaemia in 11 of 197 ponies (5.6%) ponies. The odds of hyperinsulinaemia increased by a factor of 6.53 (95% confidence interval: 2.95, 15.21) when BCS was ≥7.Main limitationsThe OST was not performed in all ponies.ConclusionsIncreased adiposity, laminitis and metabolic derangements are prevalent in this native Irish pony breed.

show abstract

Insulin dysregulated horses metabolic responses to forage pellets

Macon,

Harris,

McClendon

et al. 2024

Journal of Equine Veterinary Science

View full text Add to dashboard Cite

Seasonal Insulin Responses to the Oral Sugar Test in Healthy and Insulin Dysregulated Horses

Cited by 9 publications

References 36 publications

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

Obesity and obesity‐associated metabolic disease conditions in Connemara ponies in Ireland

Insulin dysregulated horses metabolic responses to forage pellets

Contact Info

Product

Resources

About