Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double-blind trial

Impact of Mass Azithromycin Distribution on Malaria Parasitemia during the Low-Transmission Season in Niger: A Cluster-Randomized Trial

“…9,29 Combination therapies for IPTc such as amodiaquine plus sulfadoxine-pyrimethamine or artesunate plus sulfadoxine-pyrimethamine have been effective in areas of seasonal malaria transmission. 9,29,30 Emerging antimicrobial drug resistance has spread through malariaendemic areas and has made treatment difficult. 31 We did not measure resistance to azithromycin in Plasmodium because we were unable to perform cultures at our field site and biochemical assays for this have not been adequately described.…”

“…1,2 Cohort studies have suggested that azithromycin may reduce leading causes of childhood mortality, including respiratory disease, diarrhea, and malaria. [3][4][5][6][7] In areas with seasonal malaria transmission, repeated administration of antimalarial drugs to children during the transmission season (intermittent preventive therapy of children [IPTc]) 8,9 has been shown to reduce malaria transmission, although preventive therapy outside of the transmission season is not typically recommended. 3 However, transmission models suggest treatment during the low-transmission season of an infectious disease may provide significant or even maximum impact.…”

The effects of co-infection with human parvovirus B19 and Plasmodium falciparum on type and degree of anaemia in Ghanaian children

“…In this study, malaria was found to be closely associated with anaemia, making it a major causative factor consistent with previous studies [79,81,82] . There has been a recent scale up of malaria control interventions such as insecticide-treated bed nets and artemisinin-based combination therapy to curb the ever increasing burden of malaria in Ghana and several other endemic areas in Africa [81,[83][84][85][86][87][88][89] . This has resulted in a decrease in the prevalence of malaria in most areas [90][91][92][93] .…”

Selection of antimalarial drug resistance after intermittent preventive treatment of infants and children (IPTi/c) in Senegal

“…10 The same tendency was also observed in Mali; the post-intervention prevalence of Pfdhfr/Pfdhps quadruple mutants was significantly higher in the SP-amodiaquine group than the placebo group. 12 In areas with a long and high malaria transmission SMC will be given an all year-round treatment, there may then be a stronger selection of resistance. This could explain why this strategy is not recommended in areas of high malaria transmission (as Uganda).…”