Seasonal occurrence of the infectious stage of proliferative kidney disease (PKD) and resistance of rainbow trout, <i>Salmo gairdneri</i> Richardson, to reinfection

Foott, J. Scott; Hedrick, Ronald P.

doi:10.1111/j.1095-8649.1987.tb05771.x

Cited by 82 publications

(66 citation statements)

References 16 publications

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“…Similarly, trout which had recovered from clinical PKD infections were found to be resistant to reinfection. Resistant was induced by active infection and not just previous exposure (Foott & Hedrick, 1987). D. puntazzo recovered from E. leei infection, when challenged with the parasite again were refractive to the disease, indicating possibly the development of immunity against the parasite (Golomazou et al, 2006) This protective specific immune response is probably accompanied by a repertoire of non-specific immune factors.…”

Section: Th Emop August 2008mentioning

confidence: 99%

Fish immune response to Myxozoan parasites

Sitjà‐Bobadilla

2008

Parasite

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Summary :Myxozoan parasites are responsible for important economic losses among fisheries and aquaculture industries, and hence the high interest in studying the immune response of fish against them. The most important data available concerning the immune response of fish against myxosporeans are reviewed, with emphasis on the different innate and adaptive immune mechanisms, their relationship with natural and acquired resistance and the strategies to control and prevent myxosporoses. Cellular effectors (lymphocytes, granulocytes, phagocytes, non-specific cytotoxic cells, rodlet cells) and humoral factors (lysozyme, peroxidades, antiproteases, complement, specific antibodies) have been examined for several myxosporoses, and some immune relevant genes have been studied. This information will be crucial for the future development of vaccines and other preventive strategies such as immunomodulation and selection of disease-resistant strains

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Section: Th Emop August 2008mentioning

confidence: 99%

Fish immune response to Myxozoan parasites

Sitjà‐Bobadilla

2008

Parasite

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“…T. bryosalmonae and S. truttae began spore formation in September and all spores were apparently shed by the following spring. Brown trout acquires immunity towards these species (Foott and Hedrick, 1987 ;McGeorge, 1994). C. schurovi and C. truttae mature spores were first detected in August and over the following winter in 0+ brown trout.…”

Section: Seasonal Occurrence Of Infections and Parasite Locationsmentioning

confidence: 99%

Molecular studies on the seasonal occurrence and development of five myxozoans in farmed Salmo trutta L.

2005

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S U M M A R YFive myxozoan species, Tetracapsuloides bryosalmonae, Sphaerospora truttae, Chloromyxum schurovi, Chloromyxum truttae and a Myxobolus species were detected in farmed brown trout, Salmo trutta L. from Central Scotland. Using PCR and in situ hybridization, this study investigated the seasonal occurrence and tissue location of these species in young of the year brown trout. C. schurovi, C. truttae and Myxobolus sp. were first detected in brown trout in April, 2 months before T. bryosalmonae and S. truttae. T. bryosalmonae and S. truttae showed proliferation in the blood with intravascular stages of T. bryosalmonae accumulating in the heart. In contrast, only small amounts of PCR products of C. schurovi and C. truttae were obtained from the blood, suggesting that these species use the vascular system for transport but proliferate only in their target tissues from which large amounts of PCR product were obtained and where parasites were visible in histological sections. Large amounts of PCR product were obtained for T. bryosalmonae, S. truttae and both Chloromyxum species from the gills of brown trout, suggesting the gills as entry locus for these species. The neurotropic Myxobolus species formed plasmodia predominantly in the peripheral nerves, possibly indicating an entry route through the skin. Presporogonic stages of all other species had disappeared by September and mature spores were present from August onwards.

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“…Current studies are also examining the efficacy of Fumagillin at these dosages in protecting rainbow trout from continuous exposures to the infectious stage of the parasite. We are interested in this because it has been demonstrated that the infectious stage is present for at least 7 mo of the year at one trout culture site in California (Foott & Hedrick 1987).…”

Section: Experiments Lmentioning

confidence: 99%

Oral administration of Fumagillin DCH protects chinook salmon Oncorhynchus tshawytscha from experimentally-induced proliferative kidney disease

Hedrick¹,

Groff²,

Foley³

et al. 1988

Dis. Aquat. Org.

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The antibiotic Fumagillin DCH was found to be effective in controlling experimental infections with PKX, the myxosporean that causes proliferative kidney disease (PKD) in salmonid fish. Following 6 or 7 wk of treatment, experimentally infected chinook salmon Oncorhynchus tshawytscha showed no evidence of PKX cells, or of the renal inflammation characteristic of PKD, on withdrawal of the treatment and tor up to 7 wk afterwards. In contrast, 90 to 100 % of fish (in 2 experiments) that were injected with PKX, but not glven the antibiotic, had numerous PKX cells in the kidney and developed clinical PKD. This is the first report of an effective orally administered drug for the control of a myxozoan infection in salmonid fish.

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Seasonal occurrence of the infectious stage of proliferative kidney disease (PKD) and resistance of rainbow trout, Salmo gairdneri Richardson, to reinfection

Cited by 82 publications

References 16 publications

Fish immune response to Myxozoan parasites

Fish immune response to Myxozoan parasites

Molecular studies on the seasonal occurrence and development of five myxozoans in farmed Salmo trutta L.

Oral administration of Fumagillin DCH protects chinook salmon Oncorhynchus tshawytscha from experimentally-induced proliferative kidney disease

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