Seasonal pattern of the excision rate of melanoma and naevi

Fink, A. Michelle; R, Fialla; Steiner, Andreas

doi:10.1097/00008390-200110000-00014

Cited by 3 publications

(4 citation statements)

References 25 publications

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“…It is a welldocumented major risk factor for cutaneous malignant melanoma [33][34]. Since BCC is also related to exposure to the sun, that is possible that an increased number of melanocytic nevi might be found in BCC patients.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for basal cell carcinoma: Results from the case-control study

et al. 2010

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AbstractThe aim of the present case-control study was to assess the risk factors for Basal cell carcinoma (BCC) in the Montenegrin population. The study group was comprised of 100 consecutive patients with a diagnosis of BCC, while the control group consisted of patients who did not present skin cancer and who were individually matched to the cases by sex and age. The increased risk for BCC was associated with: the presence of nevi (odds ratio [OR] = 3.77; 95% confidence interval [CI] = 1.12–12.73), type of skin concerning to burn rather than to tan after repeated sun exposure in childhood or adolescence (OR = 3.14; 95% CI = 1.59–6.18), the skin reaction to burn after two or more hours of sunlight during childhood or adolescence (OR = 4.53; 95% CI = 2.37–8.63), the number of severe and painful sunburns during their lifetime(OR = 3.52; 95% CI = 1.68–7.38), outdoor work during the summer-time (OR = 2.73; 95% CI = 1.00–7.45), occupational exposure to chemicals (OR = 17.89; 95% CI = 2.82–113.52), history of eczema (OR = 4.17; 95% CI = 1.53–11.39), and history of previous BCC (OR = 3.86; 95% CI = 1.40–10.65). Our study confirms the role of environmental and constitutional factors in development of BCC.

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Section: Discussionmentioning

confidence: 99%

Risk factors for basal cell carcinoma: Results from the case-control study

et al. 2010

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“…At the first visit bodyweight was registered and oedema of the lower legs was graded (grade 1-3). To eliminate known influences of sun exposure on appearance of naevi (18)(19)(20), all cases and control subjects were asked to avoid sun bathing and use of sun-beds during the study period.…”

Section: First Appointmentmentioning

confidence: 99%

Spectrophotometric Analysis of Melanocytic Naevi During Pregnancy

Wyon¹,

Synnerstad²,

Fredrikson³

et al. 2007

Acta Derm Venereol

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Malignant melanoma is the most common cancer during pregnancy, but it is unknown whether melanocytic naevi in general are activated. A total of 381 melanocytic naevi in 34 Caucasian primigravidae were examined using spectrophotometric intracutaneous analysis (SIAscopy) technology in early pregnancy and prior to delivery. The Siagraphs of each naevus were then compared in order to evaluate changes over time. A total of 163 melanocytic naevi in 21 nulliparous women served as an additional control group. At the first visit none of the Siagraphs examined for the case or control groups aroused suspicion of dysplastic naevus or melanoma and no significant structural changes were noted during the observation period. However, 2.1% of the melanocytic naevi in the pregnant group increased and 1.3% decreased in size. Corresponding figures in the non-pregnant group were 1.8% and 0%, respectively. Only one naevus in a pregnant woman increased slightly in epidermal pigmentation, and a decrease in pigmentation was noted in 3.7% of the melanocytic naevi in the cases and 1.8% in the controls. None of the differences within or between the groups was statistically significant. We conclude that pregnancy does not influence the appearance of pigmented naevi. A changing naevus during pregnancy should be examined carefully and considered for excision and histopathology.

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“…The incidence and excision of melanocytic lesions varies according to season, with the peak number of excisions occurring in late summer 1 . There may be several reasons for these seasonal differences, including and increase in both ascertainment and environmental exposure as the sunlight and warmer temperatures cause changes in clothing habits and the appearance of melanocytic lesions.…”

mentioning

confidence: 99%

“…The incidence and excision of melanocytic lesions varies according to season, with the peak number of excisions occurring in late summer. 1 There may be several reasons for these seasonal differences, including and increase in both ascertainment and environmental exposure as the sunlight and warmer temperatures cause changes in clothing habits and the appearance of melanocytic lesions. In this study, we aimed to assess differences in grading of dysplasia and to quantify intraepidermal melanocytes in dysplastic naevi excised at different times of the year, using antibodies directed against proliferative (HMB-45) and melanocytic [Melan-A, also called melanoma-associated antigen recognized by T cells (MART)-1] markers.…”

mentioning

confidence: 99%

Seasonal variation in dysplastic naevi

Welsch

Marszalek²,

Young

et al. 2012

Clinical and Experimental Dermatology

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There is a relationship between sunlight and the development of melanocytic neoplasms. Because the incidence and excision of melanocytic neoplasms varies according to season, we sought to determine if dysplasia and/or intraepidermal melanocytic expression differed in a cohort of dysplastic naevi (DN) removed in January compared with a similar cohort removed in August. The DN were graded based on the degree of dysplasia, and the number of intraepidermal melanocytes were counted after immunohistochemical staining with HMB-45 and Melan-A. There was no seasonal difference in the grading of the dysplastic naevi in either season (P = 0.08). Comparing 85 cases from August and 86 from January, there was a larger number of Melan-A-positive melanocytes in the August samples (P < 0.02), and a larger number of HMB-45-positive melanocytes in January (P < 0.01). This difference may be related to seasonal variations such as exposure to ultraviolet light exposure; however, there was no difference between the two groups in the degree of atypia seen.

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Seasonal pattern of the excision rate of melanoma and naevi

Cited by 3 publications

References 25 publications

Risk factors for basal cell carcinoma: Results from the case-control study

Risk factors for basal cell carcinoma: Results from the case-control study

Spectrophotometric Analysis of Melanocytic Naevi During Pregnancy

Seasonal variation in dysplastic naevi

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