Seasonal regulation of behaviour: what role do hormone receptors play?

Watts, Heather E.

doi:10.1098/rspb.2020.0722

Cited by 24 publications

(19 citation statements)

References 120 publications

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“…Among these genes, NCOR1 , a nuclear hormone receptor co-repressor that mediates transcriptional repression of thyroid and androgen hormone together with retinoic acid receptors ( 69 , 70 ), was lowly expressed in 19 tissues during fall and highly expressed in 10 tissues in summer. This observation is in line with the potential role that hormonal receptors regulation can play in adaptation to seasonal variation ( 47 ).…”

Section: Discussionsupporting

confidence: 85%

“…At the seasonal level, our results highlight the importance of the brain-gonadal hormonal axis. Many physiological and behavioral changes across seasons such as breeding, mating, molting, foraging, and hibernation ( 6 , 47 , 67 , 68 ) are known to be regulated by the endocrine system in mammals and birds, especially by the brain-thyroid and brain-gonadal axes, and can elicit different reactions depending on the receiving tissues. This is reflected in the tissue-specific seasonal variation in gene expression that we have undercovered, which affects prominently testis, breast and many brain regions.…”

Section: Discussionmentioning

confidence: 99%

“…Hormones (Watts 2020;Tendler et al 2021) have been described to broadly regulate the body's seasonal physiology (Hanon et al 2008;Dardente et al 2014;Lomet et al 2018). Thus, to explore whether genes that encode peptide hormones undergo particularly strong seasonal changes, we used a list of 62 genes with hormone-encoding capability based on Mirabeau et al (Mirabeau et al 2007) (Methods, Table S15).…”

Section: Seasonal Variation Of Gene Expression Of Hormone Genesmentioning

confidence: 99%

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Day-night and seasonal variation of human gene expression across tissues

Wucher

Sodaei

Amador

et al. 2021

Preprint

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Circadian and circannual cycles trigger physiological changes whose reflection on human transcriptomes remains largely uncharted. We used the time and season of death of 932 individuals from GTEx to jointly investigate transcriptomic changes associated with those cycles across multiple tissues. For most tissues, we found little overlap between genes changing expression during day-night and among seasons. Although all tissues remodeled their transcriptomes, brain and gonadal tissues exhibited the highest seasonality, whereas those in the thoracic cavity showed stronger day-night regulation. Core clock genes displayed marked day-night differences across multiple tissues, which were largely conserved in baboon and mouse, but adapted to their nocturnal or diurnal habits. Seasonal variation of expression affected multiple pathways and were enriched among genes associated with SARS-CoV-2 infection. Furthermore, they unveiled cytoarchitectural changes in brain subregions. Altogether, our results provide the first combined atlas of how transcriptomes from human tissues adapt to major cycling environmental conditions.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Seasonal Variation Of Gene Expression Of Hormone Genesmentioning

confidence: 99%

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Day-night and seasonal variation of human gene expression across tissues

Wucher

Sodaei

Amador

et al. 2021

Preprint

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“…We can explain this drop in ER concentration in rabbits by the decrease in estradiol levels. It is well recognized that there is an inverse relationship between the abundance of sex steroid receptors and circulating hormone levels (Watts, 2020).…”

Section: Immunolocalization Of Ers In the Adrenal Glandmentioning

confidence: 99%

Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum

Hammoudi¹,

Boulahbel²,

Chentouh³

et al. 2021

J Biochem Technol

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This research deals with the organic extracts impact of Bunium incrassatum on the immune expression of estrogen receptors that is the assessment of the effect of organic extracts from the seeds of Bunium incrassatum (Apiaceae) on the immune labelling of estrogen receptors in the adrenal gland of pregnant rabbits from the local population (Oryctolagus cuniculus).The work was carried out on pregnant rabbits during the last third of gestation (from day 17 to day 27 of gestation). The animals were divided into four groups which received daily oral doses: 50, 100, and 200 mg/kg/day, respectively. The group with dose 0 was taken as a control. After treatment, the rabbits were sacrificed (28 th day of gestation). Their organs were removed, defatted, and weighed then fixed in 10% formalin and the blood was collected in tubes with heparin. For immunohistochemistry, mouse monoclonal antibodies were used to determine the ER presence in the adrenal gland of rabbits. Theresults indicated that treatment with organic extract of Bunium incrassatum induced an increased rate of change in the thickness of the adrenal cortex in the treated groups compared to the control. A strong immune expression of estrogen receptors was observed in the groups treated with 50 and 100 mg / kg / day compared to the group treated with 200 mg/ kg/day. It can be concluded that estradiol has a direct effect on adrenal function in pregnant rabbits. Likewise, the components of the organic extract from the roots of Bunium incrassatum have modulatory activities for ER.

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“…Most organisms have altered physiology in adaptation to environmental stimuli such as temperature, light, and rainfall (1). These changes in physiology may manifest as seasonal variations in metabolic, reproductive, and psychological systems (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study

Guo

et al. 2021

Front. Endocrinol.

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BackgroundThyroid function can be influenced by external stimuli such as light and temperature. However, it is currently unknown whether there is seasonal variation of thyroid function in women of reproductive age. Adequate thyroid function in reproductive-aged women is necessary for optimal fetal–maternal outcomes. Therefore, this study aims to evaluate the seasonal changes in levels of thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and TSH index (TSHI) in women of reproductive age.MethodsA large retrospective study was conducted that included women aged 20–49 years who visited our outpatient or checkup center between 2012 and 2018. Thyroid function was measured using the automated immunochemiluminescent assay kit. Subjects with overt thyroid dysfunction, pregnancy, thyroid disease, cancer, and severe infectious or psychological disease were excluded. Seasonal differences of thyroid function were analyzed using the Kruskal–Wallis test or the analysis of means with transformed ranks. Spearman’s correlation was performed to evaluate the association between thyroid function parameters and age. A subset of 181 subjects was included in the longitudinal analyses. Differences in thyroid function between summer and winter were analyzed using the Wilcoxon signed-rank test.ResultsA total of 48,990 women with a median age of 39 years were included. The prevalence of subclinical hypothyroidism was lower in summer but higher in winter (5.6% vs. 7.0%, p < 0.05). The TSH, FT3, and FT4 levels and TSHI reached a peak in winter, while they declined to trough in summer. The TSH concentrations (r = 0.044, p < 0.001) and TSHI (r = 0.025, p < 0.001) were positively correlated with age, whereas FT3 (r = -0.073, p < 0.001) and FT4 (r = -0.059, p < 0.001) were negatively correlated with age. The associations of thyroid parameters with age were similar between subjects with positive thyroid peroxidase antibody (TPOAb) and those with negative TPOAb. In the matched longitudinal analysis of 181 subjects, no differences were detected in the thyroid parameters between summer and winter.ConclusionsThis retrospective single-center study showed that thyroid hormone levels and central sensitivity to thyroid hormones are influenced by age and seasonal fluctuations among women of reproductive age, while their impact on reproductive health remains to be elucidated in future studies.

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Seasonal regulation of behaviour: what role do hormone receptors play?

Cited by 24 publications

References 120 publications

Day-night and seasonal variation of human gene expression across tissues

Day-night and seasonal variation of human gene expression across tissues

Immunolocalization of Adrenal Estrogen Receptors (ERs) In Pregnant Rabbits Treated with Organic Extract of Bunium incrassatum

Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study

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