Seasonal variation in antimicrobial and phytochemical properties of frequently used medicinal bulbous plants from South Africa

Ncube, Bhekumthetho; Finnie, J.F.; Staden, J. Van

doi:10.1016/j.sajb.2010.10.004

Cited by 101 publications

(74 citation statements)

References 32 publications

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“…e bulb extracts have shown antibacterial, antischistosomal, anti-in�ammatory, and anthelmintic activity in studies by Sparg et al [100,103]. e ethanol extracts showed the best activity against several bacteria [103], and the leaf extracts show anticandidal activity with a MIC of <1 mg/mL only in spring and autumn, whereas the bulb extracts have a MIC of >1 mg/mL in all seasons [106]. e pharmacological active compounds from the bulbs of Merwilla can act against gastrointestinal ailments such as diarrhoea, intestinal worms, constipation, nausea, and stomach aches [38].…”

Section: Phytochemistry and Biological Activitymentioning

confidence: 98%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

145

114

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ere is a growing interest in natural plant-based remedies as a source for commercial products. Around 80% of the South African population use traditional medicines to meet their primary health care needs; however, only a few South African medicinal plants have been exploited to their full potential in terms of commercialization. e opportunity for bioprospecting of plant compounds for novel pharmaceuticals remains largely untapped. Certain renowned medicinal plants of international acclaim including buchu and rooibos are currently contributing to local enterprise; however, other exciting opportunities exist for commonly used plants which have not yet reached the international arena. is paper focuses on the key research and development contributions of 10 commercially important medicinal plants of South Africa. �raditional uses, scienti�c validation, commercialisation developments, as well as both potential opportunities and setbacks are discussed.

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Section: Phytochemistry and Biological Activitymentioning

confidence: 98%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

145

114

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“…Water and broth were included as negative controls. e plates were covered with lids and incubated at 37°C for 24 h [24]. Wells with bacterial growth were indicated by the colour change observed from purple to pink or colourless.…”

Section: Synthesis Of Metal Sulphide Nanoparticlesmentioning

confidence: 99%

“…All the experiments were performed in triplicate. e average values were calculated for the MFC of test material [24].…”

Section: Antifungal Activitymentioning

confidence: 99%

Antimicrobial Activity of Amino Acid-Capped Zinc and Copper Sulphide Nanoparticles

Mofokeng

Moloto

Shumbula

et al. 2018

Journal of Nanotechnology

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e synthesis of polydispersed zinc sulphide and copper sulphide nanocrystals capped with polar L-alanine (Aln) and L-aspartic acid (Asp) molecules is reported. e resulting nanocrystals were characterized by UV-visible spectroscopy (UV-Vis), photoluminescence (PL), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). UV-Vis absorption spectra of all samples were blue-shifted from the bulk band edges due to quantum confinement effects. PL emission spectrum of the nanoparticles showed peaks at 453 and 433 nm for Aln-capped ZnS and CuS nanoparticles, respectively, while peaks for Asp-capped ZnS and CuS nanoparticles were observed at 455 and 367 nm, respectively. e average particle sizes for Aln-capped ZnS and Asp-capped ZnS nanoparticles synthesized at 35°C were measured to be 2.88 nm and 1.23 nm, respectively. e antibacterial properties were tested using different strains of both positive and negative bacteria and fungi. It was found that capped-copper sulphide nanoparticles were more effective against the bacteria than cappedzinc sulphide nanoparticles. Staphylococcus aureus (ATCC 25923) was the most susceptible one with an MIC of 0.05 mg/mL for uncapped-CuS nanoparticles while Pseudomonas aeruginosa (ATCC 15442) and Cryptococcus neoformans (ATCC 14116) were the least ones with the MIC of 3.125 mg/mL for both uncapped-CuS and Aln-capped CuS.

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“…1 filter paper. The spectrophotometric quantitative analysis of total phenolic, flavonoid, gallotannin and condensed tannin contents was performed as detailed earlier (Ncube et al 2011). …”

Section: Secondary Metabolite Analysismentioning

confidence: 99%

In vitro propagation and secondary product production by Merwilla plumbea (Lindl.) Speta

2012

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Merwilla plumbea is a popular but threatened traditional medicinal plant sold at herbal markets in South Africa. It produces bioactive compounds and contributes to Traditional African Medical systems for the treatment of various diseases. Due to high demand, the plant is recommended for commercial cultivation. We investigated in vitro propagation and secondary compound production in in vitro cultures of M. plumbea, cultivated on Murashige and Skoog (Physiol Plant 15:473-497, 1962) medium supplemented with various plant growth regulators [PGRs: adenine sulphate (Ads), benzyladenine (BA), 2-isopentenyladenine (2iP), meta-topolin (mT), meta-topolin riboside (mTR), thidiazuron (TDZ), kinetin (Kin) and naphthaleneacetic acid (NAA)] and organic elicitors [casein hydrolysate (CH), glutamine (GM), haemoglobin (HB), mebendazole (MBZ), trimethoprim (TMP), yeast extract (YE) and yeast malt broth (YMB)]. A combination of 20 lM GM, 0.45 lM TDZ and 0.054 lM NAA produced the highest number of adventitious shoots per explant (30.6 shoots/explant) after 12 weeks of culture. The regenerated shoots were rooted and the plantlets successfully acclimatized. The total phenolic, flavonoid, gallotannin and condensed tannin contents were determined. The highest levels of flavonoids (50.97 lg CTE/g in shoots) and gallotannins (99.55 lg GAE/g in shoots) were recorded in combinations of 200 mg l -1 YE, 0.45 lM TDZ and 0.054 lM NAA and 100 mg l -1 YMB, 0.45 lM TDZ and 0.054 lM NAA. These increases were around 3-to 16-fold higher than in naturally-grown plants. This system offers the possibility to use in vitro culture techniques for mass propagation, secondary metabolite and pharmacological studies.

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Seasonal variation in antimicrobial and phytochemical properties of frequently used medicinal bulbous plants from South Africa

Cited by 101 publications

References 32 publications

Commercially Important Medicinal Plants of South Africa: A Review

Commercially Important Medicinal Plants of South Africa: A Review

Antimicrobial Activity of Amino Acid-Capped Zinc and Copper Sulphide Nanoparticles

In vitro propagation and secondary product production by Merwilla plumbea (Lindl.) Speta

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