Seasonal Variation in Birth Months of Patients With Oral-Facial Clefts

Yin, Jianhua; Yin, Ningbei; Liu, Lei; Zhao, Zhenmin; Wu, Di; Wang, Yongqian; Cao, Yimei

doi:10.1097/scs.0b013e3182670045

Cited by 4 publications

(9 citation statements)

References 14 publications

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“…Seasonal variation also occurs in the number of congenital anomalies, including orofacial clefts [ 7 – 9 ]. Seasonal variability in the occurrence of orofacial clefts has been reported, e.g., in Scotland [ 10 ], England [ 11 ], the United States [ 12 ], Zambia [ 13 ], Puerto Rico [ 14 ], Finland [ 15 ] and China [ 16 ]. In contrast, several studies have not confirmed the existence of seasonal variability of orofacial clefts, for example, in Georgia, USA [ 17 ], Colorado, USA [ 18 ], Northern Ireland [ 19 ] and Germany [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic – a retrospective study

Peterka

Likovský

Panczak

et al. 2018

BMC Pregnancy Childbirth

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BackgroundChoosing the optimal season for conception is a part of family planning since it can positively influence the pregnancy outcome. Changes in the monthly number of infants born with a birth defect can signal prenatal damage - death or malformation – related to a harmful seasonal factor. The aim of our paper was to search for possible seasonal differences in the numbers of new-borns with an orofacial cleft and thus for a period of conception that can increase the risk of orofacial cleft development.MethodsMean monthly numbers of live births in the Bohemia region of the Czech Republic during the years 1964–2000 were compared within a group of 5619 new-borns with various types of orofacial clefts and the control group derived from natality data on 3,080,891 new-borns.ResultsThe control group exhibited regular seasonal variation in the monthly numbers of new-borns: significantly more babies born during March–May and fewer babies born during October–December. Similar natural seasonal variation was also found in the group of babies with an orofacial cleft. However, after subdividing the cleft group according to gender and cleft type, in comparison to controls, significant differences appeared in the number of new-born girls with cleft lip during January–March and in the number of boys born with cleft palate in April – May.ConclusionsWe found significant differences from controls in the number of new-born girls with CL and boys with CP, whose dates of birth correspond to conception from April to August and to the estimated prenatal critical period for cleft formation from May to October. The latter period includes the warm season, when various injurious physical, chemical and biological factors may act on a pregnant woman. This finding should be considered in pregnancy planning. Future studies are necessary to investigate the putative injurious factors during the warm season that can influence pregnancy outcome.Electronic supplementary materialThe online version of this article (10.1186/s12884-018-1981-0) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic – a retrospective study

Peterka

Likovský

Panczak

et al. 2018

BMC Pregnancy Childbirth

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“…These data underline the fact that males and females must be assessed separately. Apart from Caton (2012) and Yin et al (2013), gender-related seasonal influences are described by some others (Owens et al, 1985;Fraser & Gwyn, 1998;Krost & Schubert, 2006;Peterka et al, 2018). Fraser and Gwyn (1998) found significant seasonal variation for males with cleft lip with or without cleft palate (CL+P) only.…”

Section: Gender Differencesmentioning

confidence: 99%

“…Summer months are characterized by higher outside temperatures and increased levels of sunlight, UV radiation, ozone concentrations, and agricultural pollutants (Krost & Schubert, 2006;Peterka et al, 2018). Some studies outside Europe, both in the northern and southern hemisphere, found significant increases in OFC development in seasons other than the summer (Charlton, 1966;Silberg et al, 1968;Amaratunga, 1989;De la Vega & Martinez, 2006;Elliott et al, 2008;Caton, 2012;Yin et al, 2013;Sofianos et al, 2018). Of these studies, those of Caton (2012) and Yin et al (2013) are most comprehensive and use control groups.…”

Section: Seasonal Variationmentioning

confidence: 99%

“…Some studies outside Europe, both in the northern and southern hemisphere, found significant increases in OFC development in seasons other than the summer (Charlton, 1966;Silberg et al, 1968;Amaratunga, 1989;De la Vega & Martinez, 2006;Elliott et al, 2008;Caton, 2012;Yin et al, 2013;Sofianos et al, 2018). Of these studies, those of Caton (2012) and Yin et al (2013) are most comprehensive and use control groups. Possible explanations for their significant increases in OFC development in winter were virus infections and/or lower intake of vitamins.…”

Section: Seasonal Variationmentioning

confidence: 99%

“…Of the above papers, only Caton (2012) and Yin et al (2013) described gender-related seasonality. It is well known that OFC gender-related epidemiological and etiological differences exist (Shaw et al, 1991;Mossey & Little, 2002;Hashmi et al, 2005;Genisca et al, 2009;Mossey et al, 2009;Kawalec et al, 2015;Burg et al, 2016;Peterka et al, 2018).…”

Section: Gender Differencesmentioning

confidence: 99%

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Seasonal Influence on the Numbers of Gender-Related Orofacial Cleft Conceptions in the Netherlands

Lek

Pool

Jong

et al. 2021

The Cleft Palate Craniofacial Journal

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Background: In the multifactorial etiology of orofacial clefts (OFCs), environmental factors play an important role. To trace the influence of these factors, the timing of the cell biological mechanisms that occur during embryological development of the primary and secondary palates must be taken into account. That is, the fusion process of the facial and palatal processes, respectively, followed by their differentiation into bone and musculature, which take place during the first trimester of pregnancy. During this period, harmful seasonal influences such as viral infections and vitamin deficiencies could induce OFC in the embryo. Aims: The aim of this study is to find out whether a seasonal conception period with an increased risk of OFC development exists, particularly gender related. Methods: This was a retrospective cross-sectional study on children with OFC born in the Netherlands from 2006 to 2016. Total conception rates of live births in the Netherlands were used as a control group. χ2 tests were performed to analyze monthly and seasonal differences. Males and females, positive and negative family history and subphenotype groups based on fusion and/or differentiation (F- and/or D-) defects, and their timing in embryogenesis were analyzed separately. Results: In total, 1653 children with OFC, 1041 males and 612 females, were analyzed. Only males with FD-defects showed a significant seasonal variation with an increase in conceptions during spring, most often in May. Conclusions: Males with FD-defects showed a significant seasonal variation with an increase in conceptions during spring. No other seasonal trends could be demonstrated.

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Seasonal Variation of Nonsyndromic Orofacial Clefts in Northern Chinese Population

Zhuang

Jiao

2021

Journal of Craniofacial Surgery

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Background: Nonsyndromic orofacial clefts (NSOC) comprise a range of disorders affecting the lips and oral cavity. Various authors evaluated seasonal influence on the occurrence of NSOC differently. The aim of present study was to investigate seasonal variation in birth of individuals with orofacial cleft in northern China. Methods: A retrospective study comprised 499 cases and 452 controls were conducted. Children with NSOC operated in The First Affiliated Hospital of Harbin Medical University from 2009 to 2015 were investigated. Controls were children patients with trauma and bone fracture from the same hospital during the same period. Data on sex, birth time, area of residence was retrospectively collected from patients' records. Chi-squared test was used for comparisons. P values less than or equal to 0.05 were considered to be significant. Results: Seasonal distribution was significantly different between cases and controls (P < 0.05). Birth time peaks of cases, especially males, occurred in winter. Furthermore, compared with controls, more cases with cleft lip/palate were born in winter (P < 0.05). There was no significant seasonal difference between female cases and controls (P > 0.05), and no statistical difference was found between cases with cleft palate and controls (P > 0.05). Conclusions: Our study revealed the presence of seasonal variation in individuals with orofacial cleft in northern Chinese population. We found a peak incidence of birth time for NSOC during winter.

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Seasonal Variation in Birth Months of Patients With Oral-Facial Clefts

Abstract: There is a possible seasonality in birth months and a difference between sexes of patients with oral-facial clefts in this native Chinese population. This approach could be useful to study the etiology and pathogenesis of oral-facial clefts.

Cited by 4 publications

References 14 publications

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic – a retrospective study

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic – a retrospective study

Seasonal Influence on the Numbers of Gender-Related Orofacial Cleft Conceptions in the Netherlands

Seasonal Variation of Nonsyndromic Orofacial Clefts in Northern Chinese Population

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