Seasonal Variation in Flares of Intestinal Behçet’s Disease

Lee, Jin Ha; Cheon, Jae Hee; Hong, Sung Pil; Kim, Tae Il

doi:10.1007/s10620-015-3863-x

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Research of gastrointestinal (GI) diseases is restricted to infectious/viral diseases [7] and inflammatory bowel diseases (IBD) [30]. The seasonal pattern of GI diseases is being debated in the research, with some studies showing peaks on spring and fall [31], summer and fall [32] [33], winter and spring [34] and even others showing no association with seasons [35]. Variation in water quality and pollution, which can differ with seasons, seems to be the external factor most related with GI diseases incidence [36] [37].…”

Section: Introductionmentioning

confidence: 99%

Seasonality of ER Admissions in Northwestern Pennsylvania: A Cross-Sectional Study

Guimarães¹,

Dawson²

2016

OJEM

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Seasonality, in the context of emergency room (ER) admissions, can be described as the periodic incidence of disease, corresponding to seasons, or other pre-established calendar periods. Respiratory diseases, in general, show a seasonal pattern with incidence peak at the winter season, however research still presents a considerable amount of inconsistency. Incidence of cardiovascular diseases (CVD) is also very well linked to the cold season. Gastrointestinal, genitourinary and neurological diseases are poorly studied in regards their seasonal patterns. This study aimed to assess seasonality of the five categories of diseases-respiratory, cardiovascular, gastrointestinal, genitourinary, and neurological-using data from a community hospital in northwestern PA. We analyzed 14 years (2000-2014) of data from the Meadville Medical Center (MMC) ER admissions. For each ER admission case, we had information about ICD-9 code, sex, insurance, race, age and date, time and year of admission. Statistical analyses were performed using SAS 9.4 University version software. We found significantly fewer cases of respiratory diseases in spring (OR = 0.757), summer (OR = 0.579), and fall (OR = 0.741), when comparing to the winter season; however, seasonal differences were not found for cardiovascular, genitourinary, and neurological diseases. The implications of these results will primarily be used to improve Meadville's public health policies for cold seasons, and more specifically, implement programs that prepare the ER to receive and treat respiratory cases more efficiently in the cold season.

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Section: Introductionmentioning

confidence: 99%

Seasonality of ER Admissions in Northwestern Pennsylvania: A Cross-Sectional Study

Guimarães¹,

Dawson²

2016

OJEM

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“…Hippocrates proposed that meteorological changes could affect human health in the fifth century (Nastos and Matzarakis 2006 ). And the impact of meteorological factors on acute gouty arthritis (Park et al 2017 ), rheumatoid arthritis (Azzouzi and Ichchou 2020 ), systemic lupus erythematosus, and Behcet’s disease (Lee et al 2015 ) has now been demonstrated. As a common emergency in otorhinolaryngology, the etiology of SSNHL is not clear.…”

Section: Discussionmentioning

confidence: 99%

Association of sudden sensorineural hearing loss with meteorological factors: a time series study in Hefei, China, and a literature review

Li,

Han,

et al. 2024

Environ Sci Pollut Res

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Air pollution can cause disease and has become a major global environmental problem. It is currently believed that air pollution may be related to the progression of SSNHL. As a rapidly developing city in recent years, Hefei has serious air pollution. In order to explore the correlation between meteorological variables and SSNHL admissions, we conducted this study. This study investigated the short-term associations between SSNHL patients admitted to the hospital and Hefei climatic variables. The daily data on SSNHL-related hospital admissions and meteorological variables containing mean temperature (T-mean; °C), diurnal temperature range (DTR; °C), atmospheric pressure (AP; Hp), and relative humidity (RH; %), from 2014 to 2021 (2558 days), were collected. A time-series analysis integrating distributed lag non-linear models and generalized linear models was used. PubMed, Embase, Cochrane Library, and Web of Science databases were searched. Literature published up to August 2023 was reviewed to explore the potential impact mechanisms of meteorological factors on SSNHL. The mechanisms were determined in detail, focusing on wind speed, air pressure, temperature, humidity, and air pollutants. Using a median of 50.00% as a baseline, the effect of exceedingly low T-mean in the single-day hysteresis effect model began at a lag of 8 days (RR = 1.032, 95% CI: 1.001 ~ 1.064). High DTR affected the admission rate for SSNHL on lag 0 day. The significance of the effect was the greatest on that day (RR = 1.054, 95% CI: 1.007 ~ 1.104) and then gradually decreased. High and exceedingly high RH affected the admission rate SSNHL on lag 0 day, and these effects lasted for 8 and 7 days, respectively. There were significant associations between all grades of AP and SSNHL. This is the first study to assess the effect of meteorological variables on SSNHL-related admissions in China using a time-series approach. Long-term exposures to high DTR, RH values, low T-mean values, and all AP grades enhance the incidence of SSNHL in residents. Limiting exposure to extremes of ambient temperature and humidity may reduce the number of SSNHL-related hospital visits in the region. It is advisable to maintain a suitable living environment temperature and avoid extreme temperature fluctuations and high humidity. During periods of high air pollution, it is recommended to stay indoors and refrain from outdoor exercise.

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“…Within the scope of our investigation, we have not seen any reports of worsening of symptoms due to the climate or seasonal changes limited to skin involvement in BD. However, Lee et al report a higher rates of relapse of symptoms in spring and autumn, although that report was limited to intestinal BD [22], Krause et al reported that seasonal exacerbation of joint pain, mainly related to autumn (50%) and/or spring (38%) [23], and Kim et al reported that some patients with BD had worse symptoms in spring and autumn [24]. Lee et al surmised that the high rate of symptom relapse due to seasonal changes may be related to the effects of a large temperature difference between day and night in spring and autumn on the immune system and vitamin D deficiency [22].…”

Section: Discussionmentioning

confidence: 95%

Identification of physical and psychosocial problems based on symptoms in patients with Behçet’s disease

et al. 2019

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The purpose of this study was to use the International Classification of Functioning, Disability and Health (ICF) to identify physical and psychosocial problems associated with symptoms of Behçet's disease (BD) in Japanese patients. Thirty patients with BD were interviewed in a pilot study using the "ICF Checklist", and a team of medical experts selected categories related to physical and psychosocial aspects of BD. To identify specific physical and psychosocial problems of Japanese patients with BD, 100 new patients were interviewed using the selected categories. Among the 128 categories in the original ICF Checklist, 80 categories were identified as impaired, and another 12 ICF categories were added based on expert discussion of patients input. The number of problem categories was significantly greater in patients with BD with eye involvement and fatigue (eye involvement, 25.7 categories; fatigue, 25.2 categories; both P < 0.001). Specifically, patients with eye involvement had more difficulties with problems in daily life, such as writing (odds ratio 4.2), understanding such nonverbal messages as gestures and facial expressions (13.7), moving (5.7), walking in intense sunlight and bright light (17.6), and patients with fatigue had more difficulties with climate problems such as symptoms getting worse at the turn of the seasons or on cold days (2.5), compared to those without these symptoms. This study demonstrated that support focusing not only on physical symptoms but on other aspects of life as well is necessary for patients with BD, particularly patients with eye involvement and fatigue.

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Seasonal Variation in Flares of Intestinal Behçet’s Disease

Abstract: In this study, intestinal Behçet's disease demonstrated a biphasic pattern (peaks in spring and autumn) in exacerbations of disease, suggesting that seasonal or exogenous factors may be involved in the flares of intestinal Behçet's disease.

Cited by 12 publications

References 45 publications

Seasonality of ER Admissions in Northwestern Pennsylvania: A Cross-Sectional Study

Seasonality of ER Admissions in Northwestern Pennsylvania: A Cross-Sectional Study

Association of sudden sensorineural hearing loss with meteorological factors: a time series study in Hefei, China, and a literature review

Identification of physical and psychosocial problems based on symptoms in patients with Behçet’s disease

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