Seasonal Variation in Month of Diagnosis of Polish Children with Type 1 Diabetes - A Multicenter Study

Szypowska, Agnieszka; Ramotowska, Anna; Wysocka‐Mincewicz, Marta; Mazur, Artur; Lisowicz, Lucyna; Beń‐Skowronek, Iwona; Sieniawska, Joanna; Klonowska, Bożenna; Charemska, Dorota; Nawrotek, Jolanta; Jałowiec, Irena; Bossowski, Artur; Jamiołkowska, Milena; Pyrżak, Beata; Miszkurka, Grażyna; Szalecki, Mieczysław

doi:10.1055/s-0043-125321

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…In the similar way, most autoimmune diseases “go viral” seasonally, e.g., T1D, multiple sclerosis (MS), systemic lupus erythematosus (SLE), psoriasis, and rheumatoid arthritis (RA), inflammatory bowel diseases (IBD), autoimmune liver diseases (ALDs), autoimmune thyroid disease (AITD), coeliac disease, Sjögren’s syndrome (SS) and systemic sclerosis (SSc) [ 19 ]. First reported by Franklin Adams in 1926, disease breaks out in the winter season “immediately after such an infection” [ 9 ], and this has been later confirmed in large studies [ 20 , 21 , 22 ]. T1D diagnosis peaks in the colder months of late autumn to early spring, while it drops in the summer.…”

Section: Seasonal Patterns Of Viral and Autoimmune Diseasesmentioning

confidence: 92%

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

2020

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Type 1 diabetes (T1D) is a chronic autoimmune disorder that results from the selective destruction of insulin-producing β-cells in the pancreas. Up to now, the mechanisms triggering the initiation and progression of the disease are, in their complexity, not fully understood and imply the disruption of several tolerance networks. Viral infection is one of the environmental factors triggering diabetes, which is initially based on the observation that the disease’s incidence follows a periodic pattern within the population. Moreover, the strong correlation of genetic susceptibility is a prerequisite for enteroviral infection associated islet autoimmunity. Epidemiological data and clinical findings indicate enteroviral infections, mainly of the coxsackie B virus family, as potential pathogenic mechanisms to trigger the autoimmune reaction towards β-cells, resulting in the boost of inflammation following β-cell destruction and the onset of T1D. This review discusses previously identified virus-associated genetics and pathways of β-cell destruction. Is it the virus itself which leads to β-cell destruction and T1D progression? Or is it genetic, so that the virus may activate auto-immunity and β-cell destruction only in genetically predisposed individuals?

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Section: Seasonal Patterns Of Viral and Autoimmune Diseasesmentioning

confidence: 92%

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

2020

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“…[10] Similar observation was recently documented in Poland. [30] It is believed that the rainy cold season increases the risk of viral infections and reduces sunderived vitamin D acquisition; factors that are known to trigger islet autoimmunity with progression to overt PDM. [30] Most of our subjects dwelt in urban centers at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…[30] It is believed that the rainy cold season increases the risk of viral infections and reduces sunderived vitamin D acquisition; factors that are known to trigger islet autoimmunity with progression to overt PDM. [30] Most of our subjects dwelt in urban centers at diagnosis. This finding is concordant with similar observations documented by John et al from north-central Nigeria and Hayes et al from Western Australia.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Survey of Pediatric Diabetics at a Tertiary Healthcare Center in Uyo, South-South Nigeria

Ayoade¹,

Amadi²,

Adesina³

et al. 2020

AJP

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“…The viral aetiology of T1D was first proposed in the mid-1920s, describing a seasonal variation of T1D onset with peaks in diagnoses occurring in the colder months, reflecting that of seasonal viral variation [114,115], then revisited decades later in relation to coxsackievirus B (CVB) infection in 1969 [116]. The seasonality of T1D diagnosis has been since confirmed in larger studies in nonequatorial regions [117][118][119]. The finish DIPP cohort revealed the appearance of islet autoantibodies in a seasonal pattern, with IA following the seasonality of viral infection [45].…”

Section: Historical Association Between Ev and T1dmentioning

confidence: 99%

Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

Isaacs¹,

Foskett²,

Maxwell³

et al. 2021

Preprint

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For over a century, viruses have left a long trail of evidence implicating them as frequent suspects in the development of type 1 diabetes. Through vigorous interrogation of viral infections in individuals with islet autoimmunity and type 1 diabetes using serological and molecular virus detection methods, and mechanistic studies of virus infected human pancreatic β-cells, the prime suspects have been narrowed down to predominantly human enteroviruses. Here we provide a comprehensive overview of evidence supporting the hypothesised role of enteroviruses in the development of islet autoimmunity and type 1 diabetes. We also discuss concerns over the historical focus and investigation bias toward enteroviruses, and summarise current unbiased efforts aimed at characterising the complete population of viruses (the “virome”) contributing early in life to the development of islet autoimmunity and type 1 diabetes. Finally, we review the range of vaccine and antiviral drug candidates currently being evaluated in clinical trials for the prevention and potential treatment of type 1 diabetes.

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Seasonal Variation in Month of Diagnosis of Polish Children with Type 1 Diabetes - A Multicenter Study

Abstract: Seasonal variation in incidence of T1D diagnosis of Polish children supports the role of different environmental factors in diabetes onset. The majority of children were diagnosed with diabetes in autumn and winter.

Cited by 11 publications

References 27 publications

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D

Retrospective Survey of Pediatric Diabetics at a Tertiary Healthcare Center in Uyo, South-South Nigeria

Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

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