Seasonal Variation in Skin Sensitivity to Aeroallergens

Choi, Inseon S.; Lee, Seung Sin; Myeong, Eun; Lee, Jeong Won; Kim, Woo Jin; Jin, Joon

doi:10.4168/aair.2013.5.5.301

Cited by 13 publications

(15 citation statements)

References 25 publications

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“…Cat allergen exposure is believed to be involved in 29% of asthma cases in the United States of America where 17% of the population is estimated to be sensitized to cat allergens (14). Cat is a popular pet all over the Kingdom of Saudi Arabia and could possibly be related to over 50% cat allergen sensitization observed in the present study.Seasonal variation in skin test reactivity to cat allergen has been reported with less frequent occurrence during summer time (15). However, the reactivity to cat allergen remained high for almost ten months in the present study both in winters and in summers.…”

Section: Discussion:-contrasting

confidence: 58%

Aeroallergen Skin Prick Test Reactivity Lacks Seasonal Variation in Riyadh Region.

Shakoor¹,

Alanazi²,

Aldosari³

et al. 2016

IJAR

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Background:-Exposure to aeroallergens varies in different seasons and correlates with increased frequency of sensitized individuals seeking medical aid. Objectives:-Based on skin prick reactivity during each calendar month of the year the reactivity pattern of aeroallergens was assessed. Methods:-This was a retrospective analysis of data of 238 patients (165 female and 73 male; mean age 26+11 years) with airway allergy undergoing skin prick testing between 2014 and 2016 at King Khalid University Hospital, Riyadh. A wheal diameter measuring 3 mm or more was considered as a positive reaction. Results:-Among the individuals tested there were 98 (41.1%) patients with asthma, 115 (48.3%) had rhinitis and 25 (10.5%) were suffering from hay fever. The most frequently reacting indoor aeroallergen was cat in 120 (50.2%) patients followed by Dermatophagodies farinae in 78 (32.6%), Dermatophagodies pteronyssinus in 67 (28%) and Aspirgillus in 57 (23.8%). Among the outdoor aeroallergens cynodon dactylon reactivity was observed in 90 (37.6%) patients followed by salsola kali in 86 (36.2%) and lolium perenne in 83 (34.7%). Reactivity against the cat allergen was consistently higher than the house dust mite allergens peaking in October until the month of March. Reactivity pattern of salsola kali, cynodon dactylon and lolium perenne was almost similar and remained higher than the other pollens between the months from September to May. Data for the months of July and August were not available. Conclusion:-Skin prick test reactivity against aeroallergens was not only high in Riyadh region but was also devoid of seasonal variations.

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Section: Discussion:-contrasting

confidence: 58%

Aeroallergen Skin Prick Test Reactivity Lacks Seasonal Variation in Riyadh Region.

Shakoor¹,

Alanazi²,

Aldosari³

et al. 2016

IJAR

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“…The relative risk for asthma symptoms and airway hyper-responsiveness (AHR) in HDM-sensitive children is 6.71 2. The concentrations of, and sensitization rates to, HDM allergens are higher in autumn than in summer,3 and exercise-induced asthma is highly prevalent and more severe in winter in accordance with the more frequent and severe sensitization to HDM in winter than in summer 4…”

Section: Introductionmentioning

confidence: 99%

Usefulness of House Dust Mite Nasal Provocation Test in Asthma

Choi

Kim

Won

et al. 2017

Allergy Asthma Immunol Res

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PurposeWe previously reported that the skin prick test was sensitive and the serum specific immunoglobulin E test was specific for predicting positive airway responses to house dust mites (HDMs) in patients with asthma. Because the nose and bronchus are one airway, the nasal provocation test would be more specific for predicting the bronchial responses to HDM than the skin test.MethodsThe allergy skin prick test and nasal and bronchial provocation tests using HDM (Dermatophagoides farinae) were performed in 41 young men (age, 19–28 years) who wanted military certification for asthma. The nasal responses to HDM was scored according to the severity of rhinorrhea, sneezing, and nose itching.ResultsThe prevalence of a positive skin prick test to HDM did not significantly differ between patients with (n=24) and without (n=17) an early airway reaction (EAR; 79.2% vs 70.6%, P=0.534). However, the prevalence of a positive nasal test was significantly higher in the airway responders than in the others (37.5% vs 0%, P=0.005). The concordance of a positive response to the nasal test (κ=0.332, P=0.004) but not to the skin prick test (κ=0.091, P=0.529) was significant with an EAR. The diagnostic sensitivity of the nasal test (37.5%) was lower than that of the skin prick test (79.2%), but the specificity was higher (100% vs 29.4%).ConclusionsThe skin prick test is more sensitive, whereas the nasal test is more specific and accurate, for predicting an EAR to HDM in patients with asthma.

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“…In a study done by Choi SI et al, (22) they also demonstrated seasonal variation in Allergy symptoms correlated with SPT positivity for number of Allergens, especially for pollens.…”

Section: Results and Analysismentioning

confidence: 99%

A Study of Allergic Sensitization to Eight Common Allergens in Pediatric Patients With Nasobronchial Allergy

Tikkas¹,

Dave²,

Choudhary³

et al. 2015

jemds

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This observational study was done in Department of Pediatrics to see the sensitization pattern among 128 allergic children clinically identified. Eight common Allergens were selected for Skin Prick Testing (SPT). Results were analysed and correlated with other clinical factors. Overall, SPT positivity to one or more Allergen was found in 85.71% of study population. All common Allergen in decreasing order of proportion of sensitivity were cockroach(61.71%), house dust (58.59%), holoptelea (52.34%), prosposis (52.34%), parthenium (47.65%), A. fumigates (48.43%), A. alternate (42.96%), A. niger (38.28%). It was also found that 111 (86.7%) patients had positive response to atleast 1 Allergen and poly-sensitization was more common, observed in 78.9% patients. As Burlingtonent clinical score increase from <8 to >8, there is increase in SPT positivity with different Allergens, but there is no rational trend between higher scores (8-12, 13-20 and >20) and SPT positivity. Group of patients, who shows seasonal variation of symptoms, family history of Allergy and residing in industrial areas etc, also showed variable SPT sensitization pattern. KEYWORDS: Skin prick test, sensitization, Allergens, Pediatric patients. INTRODUCTION:The concept of Allergy was introduced by Clemens von pirquet in 1906. (1) Kimishige (2) and co-workers were the first to isolate and describe IgE in 1960 that was the major breakthrough in the understanding the mechanism of Allergy. Philip gell and coombs, (3) designed the scheme of four type of hypersensitivity reaction known as type I to type IV. (4) The word Allergy was restricted to type I hypersensitivity. Asthma and Allergic conditions such as Allergic rhinitis are major public health problems, prevalence is 10-30% in different geographical areas, according to the world Allergy organization report. (5) In our country 20-30% of population suffers from Allergic rhinitis (6) and about 1/3 of them suffer from Bronchial Asthma. There are numbers of Allergen groups, that may cause Allergic symptoms, like pollen grains fungal spores, insect debris, house dust mites, animal dander, chemicals, and foods etc. (6)(7)(8)(9) Among these pollen grains and fungal spores are the most important Allergens in the air. (8-10) Allergic disorders are diagnosed by number of tests including skin Allergy testing and serum Allergy testing which is bioassay that detect presence of Allergen specific IgE on patients' blood/ mast cells. (2) Allergy skin testing can be percutaneous (Scratch, puncture or prick technique) and intradermal technique. [11,12] Skin Prick Testing technique have good sensitivity and specificity [13] to find out common Allergen in Pediatric patients. Common Allergens for children are house dust, cockroach, parthenium, holoptelea, prosposis, aspergillus fumigates, apergillus niger, alternaria alternate. (6)(7)(8)(9) In our study we tried to find out the correlation between clinical suspicion of Allergy and Allergy skin prick testing (SPT), as well as direct correlation between increasing sy...

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Seasonal Variation in Skin Sensitivity to Aeroallergens

Cited by 13 publications

References 25 publications

Aeroallergen Skin Prick Test Reactivity Lacks Seasonal Variation in Riyadh Region.

Aeroallergen Skin Prick Test Reactivity Lacks Seasonal Variation in Riyadh Region.

Usefulness of House Dust Mite Nasal Provocation Test in Asthma

A Study of Allergic Sensitization to Eight Common Allergens in Pediatric Patients With Nasobronchial Allergy

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