Seasonal variation in the superficial vein thrombosis frequency

Frappé, Paul; Bertoletti, Laurent; Presles, Émilie; Buchmüller-Cordier, Andréa; Merah, Adel; Peycelon, Déborah; Tardy, Bernard; Décousus, Hervé

doi:10.1016/j.thromres.2015.10.007

Cited by 11 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 106 among the 129 studies were excluded for the reasons as follows: five studies 15–19 failed to provide data aggregated on monthly and seasonal retrieval, seven reported insufficient data, 15 were commentary literature or reviews, and 55 cannot meet the inclusion criteria. Finally, it was identified that 23 eligible studies 7–9,20–39 met the inclusion criteria of the meta-analysis, including 40,309 patients with VTE including PE, DVT, or SVT. Figure 1 summarizes the selection flow and inclusion process of the study.…”

Section: Resultsmentioning

confidence: 99%

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Zhao

et al. 2020

Phlebology

View full text Add to dashboard Cite

Objective Venous thromboembolism, including deep vein thrombosis and pulmonary embolism, is likely to cause the death of both medical and surgical patients. Despite some evidence of seasonal variation in the incidence of venous thromboembolism, the existing studies obtain contradictory results. A temporal pattern for pulmonary embolism is known, but data on deep vein thrombosis are inconclusive. The purpose of this study is to make a meta-analysis and systematically review the literature about seasonal variations of pulmonary embolism and/or deep vein thrombosis in order to objectively diagnose venous thromboembolism. Methods According to dichotomous data, risk ratios (RRs) and 95% confidence intervals (CIs) were used to compare the incidence of venous thromboembolism in different seasons. The research was classified according to pulmonary embolism mortality, pulmonary embolism/deep vein thrombosis incidence, latitude/elevation/climatic types, and monthly incidence for four subgroup comparisons. There were a total of 23 eligible studies, in which 40,309 patients with venous thromboembolism were compared. Results The pooled total venous thromboembolism incidence was 27.2% in winter, 23.1% in spring, 24.6% in summer, and 25.1% in autumn. According to the results of pooled analysis, the incidence of venous thromboembolism in winter was much higher than that in summer (RR = 1.12, 95% CI: 1.01–1.24, adjusted P = .04), especially deep vein thrombosis. Moreover, the incidence of venous thromboembolism in summer and autumn was lower than that in winter in low-latitude (<200 m) areas and median low-latitude (0–50°-N) areas. Interestingly, the frequency of pulmonary embolism mortality was the largest in spring and smallest in summer (spring > winter ≈ autumn > summer). For monthly data, a statistically significantly lower incidence of venous thromboembolism was observed in May and July than in October. Conclusions The study revealed a significantly higher incidence of venous thromboembolism and deep vein thrombosis in winter than in summer. Pulmonary embolism mortality occurred more frequently in spring than during other seasons. A statistically significantly lower incidence of venous thromboembolism was observed in May and July compared with that in October.

show abstract

Section: Resultsmentioning

confidence: 99%

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Zhao

et al. 2020

Phlebology

View full text Add to dashboard Cite

show abstract

“…1 In the past, SVT has been considered a benign, self-limiting disorder, requiring only symptomatic treatment. 2,3 However, recent evidence showing that SVT is closely linked to occurrence of deep vein thrombosis (DVT) or pulmonary embolism (PE) indicates the relevance of this condition.…”

Section: Introductionmentioning

confidence: 99%

Risk of venous and arterial thrombotic events in patients diagnosed with superficial vein thrombosis: a nationwide cohort study

Cannegieter

Horváth‐Puhó

Schmidt

et al. 2015

Blood

View full text Add to dashboard Cite

Key Points• In the 3 months after isolated SVT, the risk of a deep venous event or pulmonary embolism is 3.4%.• This risk remains fivefold increased more than 5 years after the superficial event.Recently, it has become apparent that superficial vein thrombosis (SVT) can have serious complications. However, the magnitude of the risk of subsequent deep venous and arterial thrombotic events remains unknown. We examined this in a nationwide population-based setting during a period when SVT was not treated routinely with anticoagulants. The Danish National Registry of Patients, covering all Danish hospitals, was used to identify 10 973 patients with a first-time diagnosis of SVT between 1980 and 2012. A comparison cohort of 515 067 subjects, matched by age, gender, and calendar year, was selected from the general Danish population. Outcomes were venous thromboembolism, acute myocardial infarction, ischemic stroke, and death. During median follow-up of 7 years, the incidence rate of venous thromboembolism was 18.0/1000 person-years (95% confidence interval [CI], 17.2-18.9). The highest risk occurred in the first 3 months (3.4%; 95% CI, 3.0-3.7). Compared with the general population, the hazard ratio was 71.4 (95% CI, 60.2-84.7) in this period, steadily decreasing to 5.1 (95% CI 4.6-5.5), 5 years after the SVT. The hazard ratios for acute myocardial infarction, stroke, and death were 1.2 (95% CI, 1.1-1.3), 1.3 (95% CI, 1.2-1.4), and 1.3 (95% CI, 1.2-1.3), respectively, with the highest risk also shortly after SVT. These data indicate the prognostic importance of SVT and may form the basis for clinical decisionmaking regarding anticoagulation. (Blood. 2015;125(2):229-235)

show abstract

“…One might think that since patients with varicose veins often complain of increasing swelling and heaviness of the legs during hot weather, then SVT would also occur more frequently in the summer months. However this could not be confirmed in a large analysis with 1395 patients and an observation period of 4.75 years (7).…”

Section: Heat Is Not An Additional Risk Factormentioning

confidence: 82%

Aktuelle Aspekte der Diagnostik und Therapie der Oberflächenthrombose des Beines

Stücker¹,

Reich‐Schupke²

2018

Phlebologie

View full text Add to dashboard Cite

ZusammenfassungDer derzeit aktuelle Terminus Oberflächenthrombose spiegelt besser als der alte Begriff Thrombophlebitis die Ernsthaftigkeit des Krankheitsbildes wider, welches bei etwa 25% der Patienten mit weitere thromboembolischen Komplikationen wie tiefen (Bein)Venenthrombosen und Lungenembolien einhergeht. Treten die Oberflächenthrombosen in Varizen auf, sollten diese nach Abheilung der akuten OVT saniert werden. Oberflächenthrombosen abseits der Varizen treten gehäuft bei malignen Grunderkrankungen, Thrombophilie und anderen Risikofaktoren der tiefen Beinvenenthrombose auf. Obwohl die Diagnose in der Regel klinisch gestellt werden kann, ist die Duplexsonographie unverzichtbar, um die Ausdehnung des Thrombus und ein mögliches Übergreifen des Thrombus in das tiefe Beinvenensystem zu erfassen. Dabei ist das komplette Venensystem beider Beine vollständig zu sonografieren, da der entscheidende Faktor für die Oberflächenthrombose die Hyperkoagulabilität ist und daher begleitende tiefe Venenthrombosen durchaus auch auf der Gegenseite auftreten können. Die Therapie der Oberflächenthrombose ist gestaffelt nach den betroffenen Gefäßen: 1) Bei kleinkalibrigen Astthrombosen sind Kühlung, Kompressionstherapie, nicht steroidale Antiphlogistika sowie eine Stichinzision mit Thrombusexpression angezeigt. 2) Bei Oberflächenthrombosen der Saphenavenen und großkalibriger Varizenäste über 5cm Länge wird eine Antikoagulation in Prophylaxedosierung über 4–6 Wochen empfohlen, begleitet durch eine Kompressionstherapie über 3 Monate. Bei Risikofaktoren wie Krebsleiden, Autoimmunerkrankungen oder Befall nicht variköser Venen kommt es nicht selten erst nach Absetzen einer 6wöchigen Antikoagulation zu thromboembolischen Komplikationen, so dass bei diesen Patienten entsprechende Instruktionen sinnvoll sind. 3) Reicht der Thrombus näher als 3 cm an das tiefe Venensystem heran bzw. greift er auf die tiefen Venen über, wird wie bei einer tiefen Beinvenenthrombose therapiert.

show abstract

Seasonal variation in the superficial vein thrombosis frequency

Cited by 11 publications

References 27 publications

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Seasonal variation in the frequency of venous thromboembolism: An updated result of a meta-analysis and systemic review

Risk of venous and arterial thrombotic events in patients diagnosed with superficial vein thrombosis: a nationwide cohort study

Aktuelle Aspekte der Diagnostik und Therapie der Oberflächenthrombose des Beines

Contact Info

Product

Resources

About