Seasonal variation of acute myocardial infarction related hospitalizations in the United States: Perspective over the last decade

Patel, Nileshkumar; Pant, Sadip; Deshmukh, Abhishek; Nalluri, Nikhil; Badheka, Apurva; Shah, Neeraj; Chothani, Ankit; Savani, Ghanshyambhai T.; Schwartz, Charles; Duvvuri, Srinivas; Bogin, Marcin; Vazzana, Thomas

doi:10.1016/j.ijcard.2013.12.319

Cited by 17 publications

(15 citation statements)

References 11 publications

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“…The results of this retrospective investigation in a European country with a temperate climate confirm some previous observations at different latitudes, [3][4][5] i.e. that the frequency of AMI diagnosed in the ED displays a peak during the darker period of the year, which coincides with autumn (10.3 hours per day) and winter (10.3 hours per day) in our country.…”

Section: Discussionsupporting

confidence: 89%

“…More recent studies confirmed these findings, observing that the frequency of AMI displays a winter peak and summer trough in Korea, 3 whereas another large retrospective cohort study using the US nationwide inpatient sample database also showed that the number of hospitalizations for AMI was larger in winter months compared with summer. 4 Interestingly, a recent retrospective analysis of monthly cause-specific mortality data obtained from the US Centers for Diseases Prevention and Control also revealed that cold temperature in winter was a significant trigger of deaths for cardiovascular disease. 5 At variance with these findings, however, Manfredini and colleagues studied 4014 consecutive patients with AMI presenting to an Italian Hospital during a 7-year period, and concluded that the lowest number of AMIs occurred in September.…”

Section: Introductionmentioning

confidence: 99%

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Seasonal variation in the frequency of myocardial infarction diagnosed in a large emergency department of a European country with a temperate climate

Lippi

Mattiuzzi²,

Cervellin

2015

Emerg Care J

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Previous studies at different latitudes showed that acute myocardial infarction (AMI) exhibits a seasonal variation, with higher frequency in spring and winter. We conducted a retrospective analysis to verify whether the frequency of AMI cases diagnosed in the emergency department (ED) may follow a seasonal pattern in a European country with a temperate climate. A retrospective analysis was performed in the hospital database of the University Hospital of Parma (northwestern Italy), to retrieve the total number of AMI cases diagnosed in the ED during the entire year 2010. The search for AMI cases was conducted using both ICD-9 codes and related diagnostic terms. The seasonality was defined according to the typical equinoxes and solstices at the latitude of the study. A total of 83,919 patients visited the ED of the University Hospital of Parma during the year 2010, 502 (0.6%) of whom with a final diagnosis of AMI (mean age, 73±14 years; 188 women and 314 men). The largest frequency of AMIs was observed in autumn (n=148; 29%), followed by winter (n=136, 27%), whereas the lowest frequencies were recorded in spring (n=110; 22%) and summer (n=108; 22%). The difference in frequency distribution of AMI cases across the four seasons of the year was found to be statistically significant (P<0.001), and this trend was independent from sex and age. Compared to the summer period (i.e., the season with the lowest frequency of AMI cases), the relative risk (RR) for AMI was significantly higher in autumn (1.37; 95% CI, 1.15-1.63; P<0.001) and winter (1.26; 95% CI, 1.05-1.51; P=0.013), but not in spring (1.02; 95% CI, 0.83-1.24; P=0.857). Compared to the spring period, the RR for AMI was found also to be significantly higher in autumn (1.34; 95% CI, 1.13-1.60; P<0.001) and winter (1.24; 95% CI, 1.03-1.48; P=0.021).The results of this retrospective investigation in a European country with a temperate climate confirm that the frequency of AMI diagnosed in the ED displays a peak during the darker period of the year.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Seasonal variation in the frequency of myocardial infarction diagnosed in a large emergency department of a European country with a temperate climate

Lippi

Mattiuzzi²,

Cervellin

2015

Emerg Care J

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“…Seasonality of human disease is a prominent feature underpinning the epidemiology of many infectious; (1) cardiovascular and/or cerebrovascular; (2)(3)(4)(5)(6)(7)(8) inflammatory; (9) and neuropsychiatric diseases. (10) For example, the prevalence and severity of rhinovirus infection is greatly increased in autumn and winter, independent of the outdoor temperature.…”

Section: Introductionmentioning

confidence: 99%

Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank

et al. 2018

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The risk of CVD may be modulated by day length at temperate latitudes, and the implications of seasonality should be considered in all studies of human cardiometabolic health. Key messages In this cross-sectional study in UK Biobank, we report annual variations in cardiovascular risk factors and mortality that were associated with day length independent of environmental and lifestyle factors. These seasonal changes in day length might contribute to annual patterns in cardiovascular disease and mortality.

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“…However, when stratified into STEMI and NSTEMI, they found higher mortality among the STEMI admissions during the fall season 9 . Although inconclusive, these seasonal variations in AMI mortality have been attributed to factors such as intolerance to low temperatures among the elderly who constitute a significant part of the AMI population and others such as hemodynamic and physiologic changes associated with cooler temperatures 5,50,52 . The association between the lower rates of coronary angiography and PCI for winter admissions, as identified in our study, is of potential concern.…”

Section: Discussionmentioning

confidence: 52%

Influence of seasons on the management and outcomes acute myocardial infarction: An 18‐year US study

Vallabhajosyula

Patlolla

Cheungpasitporn

et al. 2020

Clinical Cardiology

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Background: There are limited data on the seasonal variation in acute myocardial infarction (AMI) in the contemporary literature. Hypothesis: There would be decrease in the seasonal variation in the management and outcomes of AMI. Methods: Adult (>18 years) AMI admissions were identified using the National Inpatient Sample (2000-2017). Seasons were classified as spring, summer, fall, and winter. Outcomes of interest included prevalence, in-hospital mortality, use of coronary angiography, and percutaneous coronary intervention (PCI). Subgroup analyses for type of AMI and patient characteristics were performed.

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Seasonal variation of acute myocardial infarction related hospitalizations in the United States: Perspective over the last decade

Cited by 17 publications

References 11 publications

Seasonal variation in the frequency of myocardial infarction diagnosed in a large emergency department of a European country with a temperate climate

Seasonal variation in the frequency of myocardial infarction diagnosed in a large emergency department of a European country with a temperate climate

Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank

Influence of seasons on the management and outcomes acute myocardial infarction: An 18‐year US study

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