Seasonal Variation of HbA1c in Adult Diabetic Patients

Asplund, Johan

doi:10.2337/diacare.20.2.234a

Cited by 34 publications

(29 citation statements)

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“…Furthermore, they documented that this seasonal variation was accentuated at higher latitudes areas where greater temperature differences between winter and summer also occur. Likewise in adult diabetic patients from Sweden, Asplund reported its highest values in January (7.61%) and its lowest values in July (7.23%), with an amplitude of 0.38% (14). More recently, Kim and cols.…”

Section: Resultsmentioning

confidence: 97%

“…Our data are consistent with previous reports assessing seasonal variation of Hb A1c. Most of these works were performed in western countries from the northern hemisphere, where similar Hb A1c circannual fluctuation patterns, with higher levels during cooler autumn-winter months and lower levels during warmer summer-spring time, were described in both children and adult individuals with or without diabetes (14,16,18,(21)(22)(23). In the United States, Tseng and cols.…”

Section: Resultsmentioning

confidence: 99%

“…This variation pattern seems to be associated with the geographic location, particulary when different latitudes and respective temperature variations between winter and summer are considered (11,12). It has been suggested that seasonal fluctuations also occur in glycemic control in both type 1 and type 2 diabetic patients (13)(14)(15)(16)(17). There are several epidemiological reports coming from different geographic areas that exhibit clinical relevant Hb A1c circannual fluctuations (15,16,18,19).…”

Section: Introductionmentioning

confidence: 99%

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Seasonal variation of haemoglobin A1c in a Portuguese adult population

Pereira

Lira

Bacelar

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Haemoglobin A1c (Hb A1c) is routinely used for monitoring glycemic control in patients with diabetes. Hb A1c seasonal fluctuations can be directly related to different biological, geographical and cultural influences. Our purpose was to evaluate seasonal variation of Hb A1c in a hospitalbased adult population over a period of 5 years. Materials and methods: We analyzed retrospectively monthly Hb A1c mean values (DCCT, %) based on all the assays performed to adult patients at a tertiary care university Portuguese hospital between 2008-2012. Results: We obtained 62,384 Hb A1c valid measurements, with a peak level found in January-February (7.1%), a trough in AugustOctober (6.8%) and an average peak-to-trough amplitude value of 0.3%. This trend was observed in both genders and age subgroups evaluated. Conclusions: There is a Hb A1c circannual seasonal pattern with peak levels occurring in winter months in this Portuguese population. This finding should be recognized in daily clinical practice to warrant better clinical and epidemiological interpretation of Hb A1c values. Arch Endocrinol Metab. 2015;59(3):231-5

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seasonal variation of haemoglobin A1c in a Portuguese adult population

Pereira

Lira

Bacelar

et al. 2015

Arch. Endocrinol. Metab.

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“…The nutritional prescription made for a diabetic individual is usually determined by taking into consideration expected physical activity, diabetes complications, and age (2). Seasonal variation of glycemic control in diabetes has been reported in some previous studies (3)(4)(5)(6)(7), but no Chinese data are available. This study seeks to investigate some effects of cultural variation on glycemic control, using the case of Chinese holidays.…”

Section: Diabetes Care 27:326 -330 2004mentioning

confidence: 95%

“…Few prior studies have evaluated the variation in glycemic control during holiday periods or particular seasons in diabetic subjects (3)(4)(5)(6)(7). Some previous studies revealed seasonal variations in glycemic control in diabetic subjects, and they generally came to similar broad conclusions.…”

Section: Research Design Andmentioning

confidence: 97%

A Prospective Study of Glycemic Control During Holiday Time in Type 2 Diabetic Patients

et al. 2004

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OBJECTIVE -In the U.K. Prospective Diabetes Study, A1C increased from 1.2 to 1.7% and fasting plasma glucose from 1.0 to 2.8 mmol/l over 10 years in type 2 diabetic patients. It is not known whether the blood glucose increase observed in long-term studies of type 2 diabetes results from small, steady increases throughout the year or from increases during discrete periods.RESEARCH DESIGN AND METHODS -To estimate the variation of actual glycemic control and its relation to holiday times, we measured A1C and fructosamine in 110 patients with type 2 diabetes. These measurements were performed four times at intervals of 4 -6 weeks; therefore, glycemic change was determined for three periods: preholiday period (from between November 13 and December 20 to between December 20 and January 20), holiday period (from between December 20 and January 20 to between January 28 and February 28), and postholiday period (from between January 28 and February 28 to between March 1 and April 10). A final measurement of A1C was obtained from 90 subjects in the following December or January.RESULTS -The mean A1C increased, but not significantly, during the preholiday (increase 0.135 Ϯ 0.723%, P ϭ 0.055) and holiday (increase 0.094 Ϯ 0.828%, P ϭ 0.239) periods. The mean A1C decreased, but not significantly, during the postholiday period (decrease 0.022 Ϯ 0.588%, P ϭ 0.695). Altogether, the A1C change during these three periods increased significantly (increase 0.207 Ϯ 0.943%, P ϭ 0.024). The mean fructosamine increased significantly during the preholiday period (increase 0.151 Ϯ 0.460 mmol/l, P ϭ 0.001), but there was no significant change during the holiday period (increase 0.057 Ϯ 0.593 mmol/l, P ϭ 0.321). However, fructosamine decreased significantly during the postholiday period (decrease 0.178 Ϯ 0.448 mmol/l, P Ͻ 0.001). Altogether, the fructosamine changes during the study periods showed no significant difference (increase 0.030 Ϯ 0.566 mmol/l, P ϭ 0.579). Between March or early April and the following December or January, there was no additional change in A1C (decrease 0.009 Ϯ 1.039%, P ϭ 0.935) for the 90 participants who returned for follow-up treatment.CONCLUSIONS -The present study demonstrates an influence of winter holidays on the glycemic control of patients who have type 2 diabetes, and this poor glycemic control might not be reversed during the summer and autumn months. Therefore, the cumulative effects of the yearly A1C gain during the winter holidays are likely to contribute to the substantial increase in A1C that occurs every year among type 2 diabetic individuals. Diabetes Care 27:326 -330, 2004P oor glycemic control in type 2 diabetes has serious consequences for health and is a major risk factor for the development of diabetes complications. Good control of blood glucose concentration leads to fewer complications (1). From the U.K. Prospective Diabetes Study data, A1C increased from 1.2 to 1.7% and fasting plasma glucose from 1.0 to 2.8 mmol/l over 10 years in type 2 diabetic subjects (1). It is not known whether t...

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HbA1c for screening and diagnosis of diabetes mellitus

Higgins¹

2012

Endocrine

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HbA1c has become the gold standard for monitoring glycemic control in patients with diabetes mellitus. The use of this test has been expanded to diagnose and screen for diabetes mellitus with the endorsement of influential diabetes societies and the World Health Organization. The literature on the use of HbA1c for the diagnosis and screening of diabetes mellitus was critically examined. There is substantial recent literature on this topic with strong advocates for the use of HbA1c to diagnose and screen for diabetes and equally strong detractors for its use. Advocates of the use of HbA1c cite challenges in respect of patient compliance and the analysis of glucose and inconsistency of diagnosis with glucose-based diabetes diagnosis with the elimination or reduction in these challenges in HbA1c-based diagnosis. Detractors of its use cite increased cost, concerns about the availability of HbA1c testing, and the influence of demographic and clinical factors on HbA1c results that make the use of a single-threshold values questionable for different ethnic and age groups. Despite the recommendation of many international diabetes societies that HbA1c be used for screening and diagnosis of diabetes mellitus, there is a wide divergence of opinion on this use.

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Seasonal Variation of HbA1c in Adult Diabetic Patients

Cited by 34 publications

References 0 publications

Seasonal variation of haemoglobin A1c in a Portuguese adult population

Seasonal variation of haemoglobin A1c in a Portuguese adult population

A Prospective Study of Glycemic Control During Holiday Time in Type 2 Diabetic Patients

HbA1c for screening and diagnosis of diabetes mellitus

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