Seasonal variations in HIOMT activity during the night in the pineal gland of 21 day old male wistar rats

Balemans, M. G. M.; Bary, F. A. M.; Legerstee, W. C.; Benthem, Jan van

doi:10.1007/bf01249192

Cited by 34 publications

(11 citation statements)

References 15 publications

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“…2) It has been shown already that N-acetylserotonin ( Balemans et a/., in preparation) and melatonin syntheses (Balemans et al, 1980(Balemans et al, , 1981b (Balemans et al, 1981c). No correlation between the present results and data obtained after white and green light application can be made yet.…”

contrasting

confidence: 46%

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat

Balemans¹,

Mans²,

Smith³

et al. 1983

Reprod. Nutr. Dévelop.

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Summary.The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and 0-acetyl-5-methoxytryptophol has been investigated using different experimental procedures. It was demonstrated that when GABA and an acetyl donor were added to the incubation medium together, a significant increase in synthesis of the N-acetylated products occurred during the night. Moreover there was a large increase in N-acetylserotonin synthesis at 15°° hrs although none was observed in the control experiments.However, when GABA was added 20 min before the acetyl donor, synthesis of the N-acetylated products was significantly less. The opposite effect was observed for the 0-acetylated indoles. These results confirm the proposal by Ebadi et al. (1982) that GABA, like norepinephrine, may be a regulator of melatonin synthesis. As melatonin is implicated in the regulation of reproduction it may be that GABA is equally significant in this regulatory effect.Introduction.

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contrasting

confidence: 46%

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat

Balemans¹,

Mans²,

Smith³

et al. 1983

Reprod. Nutr. Dévelop.

Self Cite

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“…With respect to the first point it should be noted that evidence is accumulating that even under standardized laboratory conditions pineal function varies according to season (Balemans et al, 1980(Balemans et al, , 1983. Interestingly, in humans serum melatonin levels show a bimodal annual curve with peaks in January and July (Arendt et al, 1978(Arendt et al, , 1979).…”

Section: Body Testicular and Epididymidal Weightsmentioning

confidence: 95%

Day/night changes of pineal gland volume and pinealocyte nuclear size assessed over 10 consecutive days

Diehl

Heidbüchel

Welker

et al. 1984

J. Neural Transmission

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Previous studies aimed at elucidating day/night changes of pineal gland size and pinealocyte nuclear volume have yielded contradictory results. The aim of the present investigation was to examine the above parameters over a period of 10 successive days, at 6-hour intervals under a lighting regimen of LD 12:12 (7 a.m. to 7 p.m.). It was found that changes in pineal gland volume could not be correlated with the light/dark phases; instead, a rhythm with a two-day period was encountered. Pinealocyte nuclear volume, by contrast, showed clear circadian changes, exhibiting troughs during photophase and peaks during scotophase. In this experimental series, the karyometric results conformed to the melatonin forming rhythm in the rat pineal gland as reported in the literature.

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“…5MT is thought to be derived physiologically from two sources, namely, by deacetylation of melatonin by arylacylamidase [41] and by methylation of serotonin (5-hydroxytryptamine) via hydroxyindole O-methyltransferase [42]. It remains to be determined what proportion of the physiological pool of serotonin in synaptic nerve terminals or within serotonergic synaptic clefts is contributed by CYP2D6-mediated pathways from melatonin and 5MT.…”

Section: Cyp2d6 Genetic Variation and Neuroactive Endogenous Substratesmentioning

confidence: 99%

Could Endogenous Substrates of Drug-Metabolizing Enzymes Influence Constitutive Physiology and Drug Target Responsiveness?

et al. 2006

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Integration of genomic data from pharmacokinetic pathways and drug targets is an emerging trend in bioinformatics, but is there a clear separation of pharmacokinetic pathways and drug targets? Should we also consider the potential interactions of endogenous substrates of drug-metabolizing enzymes with receptors and other molecular drug targets as we combine pharmacogenomic datasets? We discuss these overarching questions through a specific pharmacogenomic case study of the cytochrome P450 (CYP)2D6, serotonin and dopamine triad. Importantly, CYP2D6 may contribute to the regeneration of serotonin from 5-methoxytryptamine by virtue of its catalytic function as a 5-methoxyindolethylamine O-demethylase. Furthermore, serotonergic neurons provide a regulatory feedback on dopaminergic neurotransmission. Hence, we hypothesize that independent of its role as a pharmacokinetic gene, CYP2D6 may nuance the regulation of serotonergic and dopaminergic neurophysiology. Additionally, we reflect upon the contribution of hyperspecialization in biomedicine to the present disconnect between research on pharmacokinetics and drug targets, and the potential for remedying this important gap through informed dialogue among clinical pharmacologists, human geneticists, bioethicists and applied social scientists.

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Seasonal variations in HIOMT activity during the night in the pineal gland of 21 day old male wistar rats

Cited by 34 publications

References 15 publications

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat

The influence of GABA on the synthesis of N-acetylserotonin, melatonin, O-acetyl-5-hydroxytryptophol and O-acetyl-5-methoxytryptophol in the pineal gland of the male Wistar rat

Day/night changes of pineal gland volume and pinealocyte nuclear size assessed over 10 consecutive days

Could Endogenous Substrates of Drug-Metabolizing Enzymes Influence Constitutive Physiology and Drug Target Responsiveness?

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