Seasonal Variations of Nutritional Status in Maintenance Hemodialysis Patients

Abstract

Nutritional status of hemodialysis (HD) patients is influenced by a multitude of factors and it strongly correlates with morbidity and mortality. The aim of this study was to investigate the influence of seasonal changes on nutritional status in maintenance HD patients. A selected population of 84 adult (40 females and 44 males, aged 68.98 ± 13.45 years) HD (5.94 ± 6.44 years) patients were investigated. Clinical, biochemical and nutritional parameters (BMI, creatinine, urea, serum albumin, total cholesterol and Dialysis Malnutrition Score (DMS) were measured in cold (January and December) and mild (June and September) months, altogether in 336 HD sessions. Statistically significant differences between cold and mild months were found in BMI (P = 0.046), creatinine before HD (P = 0.011), urea before HD (P ≤ 0.001), urea after HD (P ≤ 0.001) and glucose (P = 0.001). Differences between male and female patients in DMS, serum albumin and creatinine level in cold and mild months were found; where females altogether had higher DMS score and lower serum albumin and creatinine levels. These results suggest that seasonal variations of clinical and laboratory variables that reflect nutritional status occur commonly among maintenance HD patients and might lead to biases in the interpretation of results in clinical studies in which measurement schedules vary during the year. Also, results suggested that female HD patients may constitute an especially vulnerable population for seasonal oscillations of nutritional status. The reasons for most of these variations are not apparent and require further investigation.

Seasonal Variation of Nutritional Status and Oxidative Stress in Haemodialysis Patients - Are They Related?

“…There was not statistically signi cant difference between season in the DMS and MIS score. These result is in line with result from our previous study (26) were we did not nd seasonal difference in DMS score nor difference between cold and mild months (26). But is important to note that in multivariate analysis MIS was most signi cant positive predictor for FTI and negative predictor for LTI and BCM.…”

“…Based on the results from our previous study (26) as well as the results from this study conducted in a mild Mediterranean climate in Dalmatia, South Croatia, we concluded that clinician should pay more attention to seasonal factors when interpreting nutritional status and oxidative stress and planning nutritive intervention for this population of maintenance HD patients. BackgroundThe data obtained in the current study will be available from the corresponding author upon reasonable request after publication of the results on the main research questions.…”

“…Various clinical and laboratory parameters were found to differ between seasons and previous studies have shown seasonal variations in blood pressure level (21), body mass composition and hydration state (22), interdialytic weight gain (3,23), body weight (24), calcium phosphate metabolism (25), clinical and laboratory variables that re ect nutritional status (26) and even cognitive impairment, depression, sleep disorders and quality of life (27) in maintenance HD patients.…”

Vitamin D status is seasonally stable in northern European dogs

“…Albumin and creatinine are biomarkers of kidney function and are routinely included in the diagnosis of chronic kidney disease. In humans, seasonal variation of kidney biomarkers has been identified, with albumin concentrations tending to be highest in winter months 47‐49 and creatinine concentrations highest in summer months 50,51 . In this study, cosinor analysis revealed statistically significant seasonal variation in both albumin and creatinine, with albumin concentrations peaking in autumn months (October and November) and creatinine concentrations peaking in late spring/early summer (May and June) in dogs.…”

Seasonal variations in nutritional status and oxidative stress in patients on hemodialysis: Are they related?

“…Various clinical and laboratory parameters were found to differ between seasons and previous studies have shown seasonal variations in blood pressure level (21), body mass composition and hydration state (22), interdialytic weight gain (3,23), body weight (24), calcium phosphate metabolism (25), clinical and laboratory variables that re ect nutritional status (26) and even cognitive impairment, depression, sleep disorders and quality of life (27) in maintenance HD patients.…”