1991
DOI: 10.1159/000158902
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Seasonal Variations of Serotonin-Induced Contractility in vitro in Bovine Middle Cerebral Artery

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Cited by 4 publications
(2 citation statements)
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“…In a previous study we found that contractile responses to 5-HT in the winter months were significantly greater that those in the summer when tested in vitro using bovine middle cerebral arteries ( 18). This agrees with contractile difference documented in guinea pig ilea ( 19).…”
supporting
confidence: 88%
“…In a previous study we found that contractile responses to 5-HT in the winter months were significantly greater that those in the summer when tested in vitro using bovine middle cerebral arteries ( 18). This agrees with contractile difference documented in guinea pig ilea ( 19).…”
supporting
confidence: 88%
“…The 5‐HT 1 receptor agonist sumatriptan was found to elicit a contraction of both human and bovine cerebral arteries, with a potency similar to that reported in previous studies in human (Parsons, 1991; Hamel et al ., 1993b), bovine (Hamel et al ., 1993b) and dog (Beattie & Connor, 1995) cerebral arteries. In bovine cerebral arteries, the maximal response elicited by sumatriptan and other 5‐HT 1 receptor agonists was predictably less than that of 5‐HT, but was also slightly smaller than that reported previously by us for sumatriptan in the same preparation (Hamel et al ., 1993b), probably a consequence of the seasonal variations in contractile 5‐HT receptors (Vinall et al ., 1991). The difference between 5‐HT and sumatriptan maximal response, however, is most likely due to the participation of 5‐HT 2A receptors in the 5‐HT‐mediated vasoconstriction in this species (Frenken & Kaumann, 1984; De Wever et al ., 1990; Foy et al ., 1992), a population of receptors which is either not present or not functional in human brain vessels (Hamel & Bouchard, 1991; Kaumann et al ., 1993).…”
Section: Discussionmentioning
confidence: 99%