Seasonal viral influenza among persons with primary antibody immunodeficiency

Ballow, Mark; Henderson, Tiffany; Scalchunes, Christopher; Blaese, R. Michael

doi:10.1016/j.jaip.2018.12.002

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…This study shows satisfactory influenza vaccine uptake among patients receiving IgRT in a large referral hospital. Our population meets WHO target vaccine coverage, parallels international findings, and greatly exceeds influenza immunization in other high-risk groups [21,25,29]. The majority of patients had previously received advice on seasonal vaccination, felt well-informed, and stated a physician as their primary information source.…”

Section: Resultssupporting

confidence: 60%

“…This is a small, single-institution study; thus, some findings may not be generalizable to other populations. A response rate of 57% exceeds many population-based questionnaires [24,29], and 76% influenza vaccine uptake parallels findings from larger international surveys in a similar population [29,34,35]. High educational attainment was noted in participants, 62% holding a tertiary level qualification, which in theory could self-bias toward active engagement with healthcare information.…”

Section: Study Strengths and Limitationssupporting

confidence: 64%

“…This was a single-center study with a small sample size; however, our results are in keeping with two North American surveys for the 2016/17 season. One reported 75% uptake among one thousand adults with a primary antibody deficiency; the other reported 76% in over 600 patients with CVID [25,29]. Neither study investigated patient insight or vaccination of co-habitants.…”

Section: Discussionmentioning

confidence: 99%

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Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

et al. 2021

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Influenza is a potential cause of severe disease in the immunocompromised. Patients with hypogammaglobulinemia, in spite of adequate replacement therapy, are at risk of significant morbidity and adverse outcomes. A seasonal vaccine is the primary prophylactic countermeasure to limit disease. The aim of this study was to evaluate the attitude, knowledge, and influenza vaccine uptake among Irish patients receiving immunoglobulin replacement therapy (IgRT), as well as uptake in co-habitants. Fifty-seven percent of patients receiving IgRT at a regional immunology referral center completed a questionnaire evaluation. Seventy-six percent of IgRT patients received the influenza vaccine for the 2019 season. Ninety-eight percent recognized that influenza could be prevented with vaccination, and 81% deemed it a safe treatment. Ninety-three percent correctly identified that having a chronic medical condition, independent of age, was an indication for vaccination. Despite excellent compliance and knowledge, many were not aware that vaccination was recommended for co-habitants, and only 24% had full vaccine coverage at home. Those who received advice regarding vaccination of household members had higher rates of uptake at home. This study demonstrates awareness and adherence to seasonal influenza vaccine recommendations among patients receiving IgRT. Over three quarters felt adequately informed, the majority stating physicians as their information source. We identified an easily modifiable knowledge gap regarding vaccination of household members. This data reveals a need to emphasize the importance of vaccination for close contacts of at-risk patients, to maintain optimal immunity and health outcome.

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Section: Resultssupporting

confidence: 60%

Section: Study Strengths and Limitationssupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

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Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

et al. 2021

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“…rates are as high as 80% is some patient cohorts. 68 Since we here showed that influenza-specific Bmem cells are readily detectable, even 1 year after previous infection, their presence can be examined without the need for a recent vaccination to determine the capacity of a PAD patient to generate antigen-specific Bmem cells. Flow cytometric detection of antigen-specific B cells would allow patients to be classified further based on the functionality of their Bmem cell compartment.…”

Section: Cγ1mentioning

confidence: 83%

“…20,[63][64][65] Vaccination responses are used in the diagnostic work-up of PAD patients. 37,41,42,[66][67][68][69] However, many PAD patients are started on IgRT directly after they are found to have reduced serum IgG. Thus, the presence of antigen-specific IgG in IgRT products often interferes with this analysis.…”

Section: Cγ1mentioning

confidence: 99%

Influenza‐specific IgG1⁺ memory B‐cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

et al. 2020

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Background. Annual influenza vaccination is recommended to all individuals over 6 months of age, including predominantly antibody deficiency (PAD) patients. Vaccination responses are typically evaluated by serology, and because PAD patients are by definition impaired in generating IgG and receive immunoglobulin replacement therapy (IgRT), it remains unclear whether they can mount an antigen-specific response. Objective. To quantify and characterise the antigen-specific memory B (Bmem) cell compartment in healthy controls and PAD patients following an influenza booster vaccination. Methods. Recombinant hemagglutinin (HA) from the A/Michigan/2015 H1N1 (AM15) strain with an AviTag was generated in a mammalian cell line, and following targeted biotinylation, was tetramerised with BUV395 or BUV737 streptavidin conjugates. Multicolour flow cytometry was applied on blood samples before and 28 days after booster influenza vaccination in 16 healthy controls and five PAD patients with circulating Bmem cells. Results. Recombinant HA tetramers were specifically recognised by 0.5-1% of B cells in previously vaccinated healthy adults. HA-specific Bmem cell numbers were significantly increased following booster vaccination and predominantly expressed IgG1. Similarly, PAD patients carried HAspecific Bmem cells, predominantly expressing IgG1. However, these numbers were lower than in controls and did not increase following booster vaccination. Conclusion. We have successfully identified AM15-specific Bmem cells in healthy controls and PAD patients. The presence of antigen-specific Bmem cells could offer

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Influenza epidemics

Wautlet

Patel

Chávez

et al. 2021

Annals of Allergy, Asthma & Immunology

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Seasonal viral influenza among persons with primary antibody immunodeficiency

Cited by 6 publications

References 7 publications

Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

Influenza‐specific IgG1⁺ memory B‐cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

Influenza epidemics

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Seasonal viral influenza among persons with primary antibody immunodeficiency

Cited by 6 publications

References 7 publications

Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

Seasonal Influenza Vaccine: Uptake, Attitude, and Knowledge Among Patients Receiving Immunoglobulin Replacement Therapy

Influenza‐specific IgG1+ memory B‐cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

Influenza epidemics

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Product

Resources

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Influenza‐specific IgG1⁺ memory B‐cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency