Seasonality of 278 neuromyelitis optica relapses in a Brazilian cohort

Seasonal distribution of attacks in aquaporin-4 antibody disease and myelin-oligodendrocyte antibody disease

“…Studies from Japan and Brazil have not detected any significant seasonal variation in the incidence of NMOSD attacks [27,28]. These relatively small studies (with 131 and 282 attacks, respectively) have included both AQP4-Ab-positive and -negative cases, with the latter representing a somewhat heterogeneous group that may have encompassed other conditions and thus hindered the detection of a possible seasonal pattern.…”