Seasonality of inflammation in the chicken: clock vs. melatonin control over the pro-inflammatory cytokine gene transcription

Turkowska, Elzbieta; Adamska, Iwona; Niedziółka, Sylwia M.; Majewski, Paweł; Skwarło-Sońta, Krystyna

doi:10.1080/09291016.2015.1073486

Cited by 4 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…methods section). In comparison to pro-inflammatory cytokine gene expression under LD, elevated night levels of IL-6 in hypothalamus and liver under LLbright, and perhaps the elevation of IL-6 in hippocampus as well as IL-1β and IL-6 in fat under DLAN were indicative of a night light-induced immune response 58 . Sleep loss has been shown to increase microglial activity and pro-inflammatory cytokine release in the hippocampus of rats 59 .…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Light at night disrupts diel patterns of cytokine gene expression and endocrine profiles in zebra finch (Taeniopygia guttata)

Mishra

Knerr

Stewart

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Increased exposure to light pollution perturbs physiological processes through misalignment of daily rhythms at the cellular and tissue levels. Effects of artificial light-at-night (ALAN) on diel properties of immunity are currently unknown. We therefore tested the effects of ALAN on diel patterns of cytokine gene expression, as well as key hormones involved with the regulation of immunity, in zebra finches (Taeniopygia guttata). Circulating melatonin and corticosterone, and mRNA expression levels of pro- (IL-1β, IL-6) and anti-inflammatory (IL-10) cytokines were measured at six time points across 24-h day in brain (nidopallium, hippocampus, and hypothalamus) and peripheral tissues (liver, spleen, and fat) of zebra finches exposed to 12 h light:12 h darkness (LD), dim light-at-night (DLAN) or constant bright light (LLbright). Melatonin and corticosterone concentrations were significantly rhythmic under LD, but not under LLbright and DLAN. Genes coding for cytokines showed tissue-specific diurnal rhythms under LD and were lost with exposure to LLbright, except IL-6 in hypothalamus and liver. In comparison to LLbright, effects of DLAN were less adverse with persistence of some diurnal rhythms, albeit with significant waveform alterations. These results underscore the circadian regulation of biosynthesis of immune effectors and imply the susceptibility of daily immune and endocrine patterns to ALAN.

show abstract

Section: Discussionmentioning

confidence: 96%

“…Studies in diurnal mammals 64 and domesticated birds 58 suggest that perturbations in LD cycle tend to alter pro-inflammatory responses in brain and peripheral tissues, perhaps through modulation of melatonin release 15 . Immununoenhancing properties of melatonin are well documented 15 .…”

Section: Discussionmentioning

confidence: 99%

Light at night disrupts diel patterns of cytokine gene expression and endocrine profiles in zebra finch (Taeniopygia guttata)

Mishra

Knerr

Stewart

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…These studies have demonstrated that difference in the responses of species to photoperiod is an attribute of group and species difference. Short day induced decrease in superoxide production and phagocytosis can partly be explained by the observation of www.nature.com/scientificreports/ Turkowska et al 14 . In their earlier experiments, they found that particular immune responses were differently modified by continuous lighting conditions and melatonin supplementation in birds 43 .…”

Section: Discussionmentioning

confidence: 99%

“…For example, the effects of photoperiodic alteration on immune functions have been well studied in mammals [8][9][10][11] . The involvement of melatonin has also been implicated in immune functions via experimental alteration in photoperiod [12][13][14] . Changes in the immune responses that occur in response to maintaining animals in short days are likely to be directly or indirectly related to elevated melatonin secretion.…”

mentioning

confidence: 99%

Photoperiodic manipulation modulates the innate and cell mediated immune functions in the fresh water snake, Natrix piscator

Singh¹,

Singh²,

Tripathi

2020

Sci Rep

View full text Add to dashboard Cite

Objectives of the current work were to investigate the role of photoperiod and melatonin in the alteration of immune responses in a reptilian species. Animals were kept on a regimen of short or long days. Blood was obtained and leucocytes were isolated to study various innate immune responses. Lymphocytes were separated from blood by density gradient centrifugation and were used to study proliferation. Respiratory burst activity was measured through nitrobluetetrazolium reduction assay while nitric oxide production by leucocytes was assayed by nitrite assay. Lymphocytes were isolated and used to study proliferation with and without B and T cell mitogens. Photoperiodic manipulation acted differentially on leucocyte counts. Nitrite release was increased while superoxide production was decreased in cultures obtained from the snakes kept on the short day regimen. Significant enhancement of mitogen induced lymphocyte proliferation was observed in cultures from the animals kept in either long or short days compared to cultures from the animals kept in natural ambient day length. Use of in vitro melatonin showed that lymphocytes from the animals, kept in long days, were more reactive. Photoperiod induces changes in immune status which may permit adaptive functional responses in order to maintain seasonal energetic budgets of the animals. Physiological responses (like elevated immune status) are energetically expensive, therefore, animals have evolved a strategy to reduce immune functions at times when energy is invested in reproductive activities. Natrix piscator breeds from September to December and elevated pineal hormone in winter suppresses reproduction while immunity is stimulated.

show abstract

Thymic E4bp4 gene transcription is up-regulated in the chicken during experimental peritonitis modified by the season-related lighting conditions

Turkowska

Pietruszka

Skwarło-Sońta

2016

Developmental & Comparative Immunology

View full text Add to dashboard Cite

Seasonality of inflammation in the chicken: clock vs. melatonin control over the pro-inflammatory cytokine gene transcription

Cited by 4 publications

References 33 publications

Light at night disrupts diel patterns of cytokine gene expression and endocrine profiles in zebra finch (Taeniopygia guttata)

Light at night disrupts diel patterns of cytokine gene expression and endocrine profiles in zebra finch (Taeniopygia guttata)

Photoperiodic manipulation modulates the innate and cell mediated immune functions in the fresh water snake, Natrix piscator

Thymic E4bp4 gene transcription is up-regulated in the chicken during experimental peritonitis modified by the season-related lighting conditions

Contact Info

Product

Resources

About