Seasonality of symptom onset in first-episode schizophrenia

Owens, Nicholas; McGorry, Patrick D.

doi:10.1017/s0033291702006712

Cited by 31 publications

(22 citation statements)

References 19 publications

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“…Although the factors driving seasonal cortisol change need further clarification, it has been known for some time that seasonal trends occur in some diseases influenced by glucocorticoid levels. Increased incidence of cardiovascular and psychiatric disorders is reported in winter and a seasonal variation of autoimmune disorders is documented. A recent study by Dopico et al found a profound pro‐inflammatory transcriptomic profile during European winter with seasonal expression profiles of over 4000 mRNAs .…”

Section: Discussionmentioning

confidence: 99%

“…A model predicting circadian rhythms of cortisol with higher oscillations in winter, resulting in an exacerbated immune response and pro‐inflammatory state during winter months has also been suggested . It has been reported that cardiovascular, psychiatric and autoimmune disease have seasonal variation, conditions which are all influenced by glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

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Where in the world? Latitude, longitude and season contribute to the complex co‐ordinates determining cortisol levels

Hadlow

Brown

Wardrop

et al. 2018

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Where in the world? Latitude, longitude and season contribute to the complex co‐ordinates determining cortisol levels

Hadlow

Brown

Wardrop

et al. 2018

Clinical Endocrinology

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“…Circadian rhythms modulate phenomena as diverse as bioluminescence in dinoflagellates1 and cognitive function in humans23, while circannual rhythms are seen in functions as diverse as flowering in plants4 and hibernation in chipmunks5, These rhythms also feature prominently in several human brain disorders. For example, prominent changes in circadian rest-activity6 and body temperature rhythms7 are seen in Alzheimer's disease, and there are seasonal rhythms of mood in seasonal affective disorder8, of symptom onset in schizophrenia9 and of human functional magnetic resonance imaging brain responses with cognitive tasks10.…”

mentioning

confidence: 99%

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease

Lim

Klein

et al. 2017

Nat Commun

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Circadian and seasonal rhythms are seen in many species, modulate several aspects of human physiology, including brain functions such as mood and cognition, and influence many neurological and psychiatric illnesses. However, there are few data regarding the genome-scale molecular correlates underlying these rhythms, especially in the human brain. Here, we report widespread, site-specific and interrelated diurnal and seasonal rhythms of gene expression in the human brain, and show their relationship with parallel rhythms of epigenetic modification including histone acetylation, and DNA methylation. We also identify transcription factor-binding sites that may drive these effects. Further, we demonstrate that Alzheimer's disease pathology disrupts these rhythms. These data suggest that interrelated diurnal and seasonal epigenetic and transcriptional rhythms may be an important feature of human brain biology, and perhaps human biology more broadly, and that changes in such rhythms may be consequences of, or contributors to, diseases such as Alzheimer's disease.

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“…For example, Aviv et al (2011) 54 , as well as Amr and Volpe (2012) 56 did not find any seasonal effect on admission rates. In the Southern Hemisphere, Davies et al (2000) 57 found a peak in first episode schizophrenia admission in the winter (August), similar to Owens and McGorry (2003) 58 . In contrast, Daniels et al (2000) 59 did not find a seasonal association in Tasmania with admission with diagnoses of schizophrenia and bipolar disorder.…”

Section: Discussionmentioning

confidence: 66%

Seasonality Shows Evidence for Polygenic Architecture and Genetic Correlation With Schizophrenia and Bipolar Disorder

Byrne

Raheja

Stephens³

et al. 2014

J. Clin. Psychiatry

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Objective To test common genetic variants for association with seasonality (seasonal changes in mood and behavior) and to investigate whether there are shared genetic risk factors between psychiatric disorders and seasonality. Methods A meta-analysis of genome-wide association studies (GWAS) conducted in Australian and Amish populations in whom the Seasonal Pattern Assessment Questionnaire (SPAQ) had been administered. The total sample size was 4,156 individuals. Genetic risk scores based on results from prior large GWAS studies of bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ) were calculated to test for overlap in risk between psychiatric disorders and seasonality. Results The most significant association was with rs11825064 (p = 1.7 × 10−6, β = 0.64, S.E = 0.13), an intergenic SNP found on chromosome 11. The evidence for overlap in risk factors was strongest for SCZ and seasonality, with the SCZ genetic profile scores explaining 3% of the variance in log-transformed GSS. BD genetic profile scores were also significantly associated with seasonality, although at much weaker levels, and no evidence for overlap in risk was detected between MDD and seasonality. Conclusions Common SNPs of very large effect likely do not exist for seasonality in the populations examined. As expected, there was overlapping genetic risk factors for BD (but not MDD) with seasonality. Unexpectedly, the risk for SCZ and seasonality had the largest overlap, an unprecedented finding that requires replication in other populations, and has potential clinical implications considering overlapping cognitive deficits in seasonal affective disorders and SCZ

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Seasonality of symptom onset in first-episode schizophrenia

Abstract: True seasonal patterns are present in schizophrenia incidence, but their consistency with other published studies and wider significance, is difficult to ascertain because of different methods used in dating incidence of disorder.

Cited by 31 publications

References 19 publications

Where in the world? Latitude, longitude and season contribute to the complex co‐ordinates determining cortisol levels

Where in the world? Latitude, longitude and season contribute to the complex co‐ordinates determining cortisol levels

Diurnal and seasonal molecular rhythms in human neocortex and their relation to Alzheimer’s disease

Seasonality Shows Evidence for Polygenic Architecture and Genetic Correlation With Schizophrenia and Bipolar Disorder

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