Seasonality of vitamin D concentrations and the incidence of vitamin D deficiency in children and adolescents from central Poland

Smyczyńska, Joanna; Smyczyńska, Urszula; Stawerska, Renata; Domagalska-Nalewajek, Hanna; Lewiński, Andrzej; Hilczer, Maciej

doi:10.5114/pedm.2019.85814

Cited by 13 publications

(26 citation statements)

References 26 publications

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“…As for seasons the highest values were in summer-July, August, September, and lowest in winter-January, February, March, with no difference between autumn and spring [19]. The level of insolation in previous months remained in close relationship with 25(OH)D levels and in Polish children a two-month shift was observed between the highest insolation and maximal 25(OH)D level [19]. This is due to long half-life of serum 25(OH)D. Indeed, the highest insolation in Poland is observed in May (4.97 kWh/m 2 /day) and the lowest in December (0.67 kWh/m 2 /day), which confirms the two-month shift.…”

Section: Discussionmentioning

confidence: 87%

“…In the study of Smyczyńska el al. (n = 1275) the highest concentrations of 25(OH)D were observed in August (incidence of deficiency was 10.7%) and minimal in January (incidence of deficiency was 80.4%) [19]. As for seasons the highest values were in summer-July, August, September, and lowest in winter-January, February, March, with no difference between autumn and spring [19].…”

Section: Discussionmentioning

confidence: 92%

“…(n = 1275) the highest concentrations of 25(OH)D were observed in August (incidence of deficiency was 10.7%) and minimal in January (incidence of deficiency was 80.4%) [19]. As for seasons the highest values were in summer-July, August, September, and lowest in winter-January, February, March, with no difference between autumn and spring [19]. The level of insolation in previous months remained in close relationship with 25(OH)D levels and in Polish children a two-month shift was observed between the highest insolation and maximal 25(OH)D level [19].…”

Section: Discussionmentioning

confidence: 96%

“…It would be interesting to investigate vitamin D levels to explain the associations of the season with severity. However, the seasonal changes of 25(OH)D concentrations in Polish children has been well documented earlier [11,19]. In the study of Smyczyńska el al.…”

Section: Discussionmentioning

confidence: 99%

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Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study

Glapa-Nowak

Szczepanik

Kwiecień

et al. 2020

JCM

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This study was to investigate whether the clinical course of inflammatory bowel disease (IBD) in a Polish paediatric cohort fits a seasonal pattern and depends on insolation. Two hundred and fourteen patients diagnosed with Crohn’s disease (CD) and 192 with ulcerative colitis (UC) aged from 3 to 18 years, were recruited in seven centres of similar latitude. The seasons were defined as winter (December–February), spring (March–May), summer (June–August), autumn (September–November). The year was also divided depending on insolation threshold (3.0 kWh/m2/day). Patients diagnosed with IBD when the isolation was >3 kWh/m2/day had poorer nutritional status than those diagnosed while insolation was below threshold (lower standardised BMI at diagnosis (−0.81 ([−1.34]–[−0.03]) vs. −0.52 ([−1.15]–0.15); p = 0.0320) and worst flare (−0.93 ([−1.37]–[−0.05]) vs. −0.66 ([−1.23]–0.17); p = 0.0344), with the need for more frequent biological treatment (45.5% vs. 32.7%, p = 0.0100). Patients diagnosed in winter were significantly younger at diagnosis (11.4 vs. 13.0; padj = 0.0180) and first immunosuppressive treatment (11.3 vs. 13.3; padj = 0.0109) than those diagnosed in other seasons. CD patients diagnosed in months with higher insolation spent more days in hospital than those diagnosed in months with lower insolation [4.6 (1.8–11.8) vs. 2.9 (1.3–6.2); p = 0.0482]. CD patients diagnosed in summer had significantly more concomitant diseases. In patients with CD, the occurrence of the worst flare was more frequent in autumn. Furthermore, the season of birth was associated with Pediatric Crohn’s Disease Activity Index at worst flare and earlier surgery. In conclusion, several clinical parameters are associated with insolation, the season of diagnosis and season of birth in the clinical course of Crohn’s disease.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study

Glapa-Nowak

Szczepanik

Kwiecień

et al. 2020

JCM

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“…From other studies, it is known that in countries such as Poland, skin synthesis of vitamin D is observed only from April to October (if the sunshine exposure is adequate) [20]. According to a recent Polish study [43], the highest levels of 25(OH)D in Poland are observed in August and the lowest in January, which could be explained by insolation and 25(OH)D synthesis during summer and the mobilization of vitamin D stored in the body (during the summer months) in the winter.…”

Section: Discussionmentioning

confidence: 99%

Salmon Intake Intervention in the Vulnerable Group of Young Polish Women to Maintain Vitamin D Status during the Autumn Season

Utri¹,

Głąbska²

2020

Sustainability

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Fish products are the main dietary source of vitamin D, but due to a low fish intake in the majority of European countries, an inadequate vitamin D intake is common, especially in the vulnerable group of young women for whom it is essential for the osteoporosis prevention. The aim of the presented study was to assess the possibility of applying salmon intake intervention for maintaining vitamin D status in young Polish women during the autumn season, in which in Poland there is not enough sunshine exposure to generate skin synthesis. The dietary intervention within VISA Study (Vitamin D In Salmon) comprised eight weeks of daily consumption of 50 g of Atlantic salmon and was conducted in a group of 47 women aged 20–30 years. Within the study, their changes of total serum 25-hydroxyvitamin D (25(OH)D) levels were analyzed and the effectiveness of the intervention depending on age, body mass index (BMI), and baseline 25(OH)D were assessed. Until the 4th week, 25(OH)D in the studied group decreased from 57.1 nmol/L to 39.9 nmol/L (p < 0.0001), but afterward it increased until the 8th week to 54.1 nmol/L (p = 0.0005), contributing to results not differing from the baseline (p = 0.7964). At the same time, the share of respondents characterized by an inadequate vitamin D status increased until the 4th week, but afterward, it decreased until the 8th week (p = 0.0002). Neither the age (in the assessed range), nor the BMI influenced 25(OH)D during the study, but only the baseline 25(OH)D was correlated with the BMI (p = 0.0419; R = −0.2980). The baseline 25(OH)D was associated with its levels during the intervention, as well as with 25(OH)D change from the baseline values (p < 0.0001). It may be concluded that, in spite of the initial decline of the 25(OH)D observed (probably connected to the starting time of the study), afterward the salmon intake intervention contributed to its increase, while the baseline 25(OH)D status was an important determinant of the intervention effectiveness during the autumn season.

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Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan

et al. 2020

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Introduction The incidence rate of vitamin D deficiency is increasing throughout the world. We measured the incidence rate of vitamin D deficiency and fibroblast growth factor 23 (FGF23) levels in 12-to 13-year-old adolescents in Japan. Materials and methods A total of 492 adolescents (247 boys and 245 girls) from Japanese community enrolled in this study. 25 hydroxyvitamin D (25(OH)D) was measured with radioimmunoassay. In the subjects with low 25(OH)D levels (≦ 20 ng/ ml), intact parathyroid hormone (iPTH), calcium (Ca), phosphorus (P), albumin (Alb), alkaline phosphatase (ALP) and FGF23 were measured. Results 25(OH)D levels were significantly lower in girls (20.9 ± 3.1 ng/ml) than in boys (22.2 ± 3.3 ng/ml) (p < 0.0001). Fifty-five boys (22.3%) and 83 (33.9%) girls showed vitamin D deficiency (< 20 ng/ml). One-hundred eighty-six (75.3%) boys and 162 (66.1%) girls showed vitamin D insufficiency (≧ 20 ng/ml, < 30 ng/ml). In the subjects whose 25(OH)D levels were ≦ 20 ng/ml, the levels of iPTH, Ca, P, Alb, ALP and FGF23 were 22.3 ± 9.0 pg/ml, 9.5 ± 0.4 mg/dl, 4.7 ± 0.6 mg/dl, 4.6 ± 0.3 g/dl, 920.8 ± 339.3 U/l and 42.6 ± 26.0 pg/ml, respectively. There was a significant negative association between serum 25(OH)D levels and iPTH [r = − 0.290 (p < 0.0001)]. There was no significant association between serum 25(OH) D levels and FGF23. Conclusion We show that 28% of Japanese 12-to 13-year-old early adolescents suffer from vitamin D deficiency. Findings from this study indicate that vitamin D deficiency requires close oversight in public health during adolescence to ensure proper bone health.

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Seasonality of vitamin D concentrations and the incidence of vitamin D deficiency in children and adolescents from central Poland

Cited by 13 publications

References 26 publications

Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study

Insolation and Disease Severity in Paediatric Inflammatory Bowel Disease—A Multi-Centre Cross-Sectional Study

Salmon Intake Intervention in the Vulnerable Group of Young Polish Women to Maintain Vitamin D Status during the Autumn Season

Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan

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