Seasons of Birth and Sub-Types of Schizophrenia

Hsieh, Hudson H.; Khan, Mujeeb H.; Atwal, S. S.; Chu, Christopher

doi:10.1192/bjp.149.1.125

Cited by 2 publications

(4 citation statements)

References 4 publications

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“…Some studies have found an association between the peak of birth seasonality and certain clinical forms, mainly disorganized subtype [ 32 ], paranoid subtype [ 33 ] or with pronounced negative symptomatology [ 34 ]. In addition, patients with schizophrenia who were exposed to an elevated risk of influenza infection during pregnancy are more likely to be single, which could indicate poorer social adjustment [ 35 ], and with the disorganized clinical subtype [ 18 ].…”

Section: The Neurodevelopmental Hypothesis Applied To Negative Symptomentioning

confidence: 99%

Neurodevelopmental and environmental hypotheses of negative symptoms of schizophrenia

Limosin

2014

BMC Psychiatry

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The negative symptoms of schizophrenia, avolition, alogia, apathy and impaired or nonexistent social functioning, are strongly correlated with the progressive course and long-term prognosis of the disease, undermining the patient’s ability to integrate socially, interpersonal skills and quality of life. At a time when new drug strategies are being developed, a better understanding of the etiology and pathogenesis underpinning the occurrence of negative symptoms constitutes an essential prerequisite for real therapeutic advances. Approaching this vulnerability from the neurodevelopmental perspective is especially pertinent with regard to the experimental studies conducted in animals. Several models have been put forward, involving a variety of topics such as the deleterious impact of a prenatal infection or of early maternal deprivation on brain development, or else the consequences of trauma and abuse suffered during childhood. These various models are based on biological abnormalities that could guide the identification of new therapeutic targets. They notably include the hyperreactivity of the hypothalamic-pituitary-adrenal axis and dysfunction of corticostriatal glutamatergic transmission. As such, in the traumagenic model, which associates neurodevelopmental and neurodegenerative processes, the dysfunction of corticostriatal glutamatergic transmission, by reducing the tonic dopamine release, could be the cause of an increase in the phasic dopamine release linked to stress. This excessive phasic response to stress may induce cerebral damage by increasing excitotoxicity and oxidative stress.

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Section: The Neurodevelopmental Hypothesis Applied To Negative Symptomentioning

confidence: 99%

Neurodevelopmental and environmental hypotheses of negative symptoms of schizophrenia

Limosin

2014

BMC Psychiatry

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“…For example, Torrey et al (1977) divided their sample of schizophrenics into paranoid and "process" (includes simple, hebephrenic, catatonic, and chronic undifferentiated schizophrenia) subgroups, and found no significant differences with regard to seasonality of birth. On the other hand, a study by Hsieh et al (1986) revealed that male paranoid schizophrenics showed a significant larger proportion of births than controls during the first quarter of the year. Thus it seems clear that further investigation is needed to elucidate the parameters of this phenomenon.…”

Section: Discussionmentioning

confidence: 96%

“…Miller reviewed the results of 43 studies, and there are many more recent studies (e.g., Baron & Gruen, 1988;Dereeef, Mukherjee, Bilder, & Schnur, 1988;Fa~nanas, Marti-Tusquets, & Bertranpetit, 1989;Hsieh, Khan, & Atwal, 1986;Kendell & Adams, 1991;Kendell & Kemp, 1987;Lo, 1986;Machon, Mednick, & Schulsinger, 1983;Newman & Bland, 1988;O'Callaghan et al, 1991;Woodard & Feldman, 1990). The results of these studies can be generally summarized as follows:…”

Section: Previous Studiesmentioning

confidence: 99%

“…With many of these variables, there are conflicting results in different studies. It is likely that there are too few studies that include these variables to lead to reliable conclusions (Baron & Gruen, 1988;Barry & Barry, 1964;Bradbury & Miller, 1985Fananas et al, 1989;Hsieh et al, 1986;Kendell & Kemp, 1987;Machon et al, 1983;Malama et al, 1988;Nasrallah & McCalley-Whitters, 1984;Parker & Neilson, 1976;Pulver, Stewart, Carpenter, & Childs, 1983).…”

Section: Several Other Variables Have Been Investigated Inmentioning

confidence: 99%

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Seasonality of Birth in Schizophrenia in Taiwan

Tam

Sewell

1995

Schizophrenia Bulletin

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The phenomenon of seasonality of birth in schizophrenia is important to the study of the etiology of this mental disorder because it helps give directions for further research. Patients' hospital files from 1981 to 1991 at two of the largest hospitals with psychiatric wards in Taiwan were reviewed, and dates of birth were collected on 3,346 patients diagnosed with schizophrenia. After adjusting for the variations of the total monthly births in the population, an Auto-Regressive Integrated Moving Average model was applied. Results support a seasonality phenomenon and indicate a disproportional excess of births in schizophrenia in the cold months (November to February) compared with the hot months (May to August). These findings are compatible with many other studies in other countries and climates. Further investigations of season-related environmental factors in the etiology of schizophrenia are recommended.

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Seasons of Birth and Sub-Types of Schizophrenia

Abstract: Inhibition of prostaglandin synthesis increases plasma lithium levels. Clinical Research, 26, 291A.

Cited by 2 publications

References 4 publications

Neurodevelopmental and environmental hypotheses of negative symptoms of schizophrenia

Neurodevelopmental and environmental hypotheses of negative symptoms of schizophrenia

Seasonality of Birth in Schizophrenia in Taiwan

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