The DOE-OBP Multi-year Program Plan (MYPP) biomass production targets are 44 million dry tons per year by 2012 and 155 million dry tons per year by 2017 (EERE Biomass Program, 2011). Macroalgae, more commonly known as seaweed, could be a significant biomass resource for the production of biofuels. The overall project objective is to conduct a strategic analysis to assess the state of macroalgae as a feedstock for biofuels production. To this end, this project provides an assessment of the potential for domestic macroalgae production and identifies the key technical issues associated with the feasibility of using macroalgae resources. Work began in FY10 as a screening analysis of the key questions related to the status of macroalgae as a feedstock resource. These efforts addressed the state of technology, types of fuels possible, a rough order-of-magnitude resource assessment, and preliminary high-level economic analysis, resulting in a Summary Report entitled Macroalgae as a Biomass Feedstock: A Preliminary Analysis (PNNL-19944).While considerable progress has been made in developing and applying GIS-based spatiotemporal models of high granularity to siting microalgal growth facilities in terrestrial landscapes in the continental U.S. (Wigmosta et al., 2011), parallel efforts to identify suitable sites for macroalgal cultivation in U.S. marine waters have yet to be reported. Such effort requires development of new analysis tools because those developed for land-based microalgal resources (Wigmosta et al., 2011) are not directly applicable to marine waters. Thus, the plan for subsequent years, starting in FY11, was to develop a multi-year systematic national assessment to evaluate the U.S. potential for macroalgae production using a GISbased assessment tool and biophysical growth model developed as part of these activities. The broad goal of this modeling effort is to develop a National Macroalgae Assessment Model for evaluating macroalgae production in marine waters within the U.S. Exclusive Economic Zone (EEZ). Focus was placed on an assessment of kelp, a group of brown macroalgae considered suitable for conversion to biofuels based on biochemical composition and growth characteristics. Progress in FY11, which focused on model development and initial application of the models to demonstration areas in offshore waters, is described in this report.During FY11, a concept map describing spatial models to identify suitable sites for producing macroalgae biomass was developed as a framework for conducting a GIS-based national resource assessment within the U.S. EEZ. The spatial models included modeling macroalgae production potential, constrained by competing uses and legal, environmental, and infrastructure considerations at specified locations in the U.S. EEZ. A literature review of these constraints was conducted, and remotely-sensed data sources were identified, downloaded, and processed using 8-day composites from 2000 to 2011 to support site screening and macroalgae growth model development. Model demon...