Seaweed polysaccharides as potential therapeutic agents against white spot syndrome virus (WSSV): a mini review

Raguraman, Vasantharaja; Ravindran, Namitha; Selvaraju, Koushalya; Govindaraju, K.

doi:10.1007/s10499-020-00587-0

Cited by 12 publications

(4 citation statements)

References 36 publications

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“…Also, the immunostimulant, antibacterial and antiviral activity reported for seaweed polysaccharides, enhances their use as a natural and environmentally friendly alternative to treat and control several diseases affecting fish, shrimp cultivation and other organisms produced through aquaculture (Marudhupandi and Inbakandan, 2015;Rizzo et al, 2017;Raguraman et al, 2020). An increased immunological response, upregulation of immune-related genes and resistance to pathogens was reported through in vitro and in vivo studies after the shrimp L. vannamei was exposed to l-carrageenan via immersion and orally (Chen et al, 2014).…”

Section: Potential Based On Results Of Other Speciesmentioning

confidence: 99%

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Guillen

Motti²,

Mangelinckx³

et al. 2022

Front. Mar. Sci.

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The role that seaweeds play as primary producers and ecosystems engineers in marine coastal ecosystems is widely acknowledged. Seaweeds, however, are also important drivers in the development of the blue bioeconomy due to their vast diversity of unique chemicals with a broad range of industrial and biotechnological applications. In tropical regions, seaweed production has been focused on a few species only, because of their hydrocolloids used in the food industry. There is a strong need to identify new applications of red seaweed species in other sectors such as aquaculture. Therefore, to diversify the culture of red seaweeds, more tropical species need to be investigated for their chemical composition and potential application in aquaculture, and then, to develop a method for a sustainable cultivation of new seaweed candidates and enhance their economic potential. Based on this context, we analyze the potential value of the red edible seaweed Acanthophora spp., an under-valued seaweed species which is naturally abundant in tropical countries, and Kappaphycus spp., a commercially valuable seaweed commonly used for polysaccharide extraction. The vast chemical diversity of seaweeds (polysaccharides, phytohormones, amino acids, and pigments) has led to research on a wide range of applications in aquaculture, including pathogen control, immunostimulant, antioxidant, bioremediation, feed, UV protectants, increase in seafood shelf life, animal colorant, and growth regulator for microalga culture. This review hopes to stimulate the interest among seaweed researchers to investigate other local seaweed species and seek greater added value of their biomass and chemical compounds and their applications in the aquaculture sector. Additionally, this information will help stakeholders to benefit from these two red seaweeds by contributing to the diversification of the blue bioeconomy in tropical countries.

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Section: Potential Based On Results Of Other Speciesmentioning

confidence: 99%

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Guillen

Motti²,

Mangelinckx³

et al. 2022

Front. Mar. Sci.

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“…Seaweed polysaccharides are recognized as high-value active molecules that improve growth performances, enhance the immune system response, and have many health benefits for aquaculture organisms [ 2 , 54 , 93 , 94 , 95 , 96 , 97 ]. In the present study, we hypothesized that the dietary administration of polysaccharide derived from brown seaweed ( Sargassum dentifolium ) ameliorates the growth performances, feed utilization, body composition, microbial communities, and growth, immunity, and stress genes expressions of the Whiteleg shrimp L. vannamei .…”

Section: Discussionmentioning

confidence: 99%

Impact of Dietary Administration of Seaweed Polysaccharide on Growth, Microbial Abundance, and Growth and Immune-Related Genes Expression of The Pacific Whiteleg Shrimp (Litopenaeus vannamei)

Abbas

Al-Souti

Sharawy

et al. 2023

Life

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This work aims to determine the impact of dietary supplementation of polysaccharide, extracted from brown seaweeds Sargassum dentifolium on growth indices, feed utilization, biochemical compositions, microbial abundance, expressions of growth and immunity-related genes, and stress genes of the Pacific Whiteleg shrimp Litopenaeus vannamei. A total of 360 post-larvae of L. vannamei were randomly distributed into a 12-glass aquarium (40 L of each) at a stocking density of 30 shrimp with an initial weight of (0.0017 ± 0.001 g). During the 90-day experiment trial, all shrimp larvae were fed their respective diets at 10% of total body weight, three times a day. Three experimental diets were prepared with different seaweed polysaccharide (SWP) levels. The basal control diet had no polysaccharide level (SWP0), while SWP1, SWP2, and SWP3 contained polysaccharides at concentrations of 1, 2, and 3 g kg−1 diet, respectively. Diets supplemented with polysaccharide levels showed significant improvements in weight gain and survival rate, compared to the control diet. Whole-body biochemical composition and the microbial abundance (the total count of heterotrophic bacteria and Vibrio spp.) of L. vannamei showed significant differences among polysaccharide-treated diets compared to the control. At the end of the feeding experiment, the dietary supplementation of polysaccharide levels enhanced the expression of growth-related genes (Insulin-like growth factors (IGF-I, IGF-II), immune-related genes (β -Glucan-binding protein (β-Bgp), Prophenoloxidase (ProPO), Lysozyme (Lys), and Crustin), and stress genes (Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) in the muscle tissue of L. vannamei. However, the current study concluded that the inclusion rate of 2 g kg–1 of polysaccharide as a dietary additive administration enhanced both weight gain and survival rate of L. vannamei, while the incorporation level of 3 g kg–1 reduces the abundance of pathogenic microbes and enhances the growth-, immunity- and stress-related gene expressions of L. vannamei.

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“…To date, there are no effective ways of preventing or treating viral infections in shrimp [21]. Nevertheless, various methods based on plants, seaweeds, nanoparticles, and probiotic bacteria [21] have been proposed for preventing WSSV infection.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of White Spot Syndrome Virus Protein VP28-Expressing Chlorella vulgaris as an Oral Vaccine for Shrimp

Kim,

Kim

et al. 2023

Viruses

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The white spot syndrome virus (WSSV) is the causative agent of white spot disease, which kills shrimp within a few days of infection. Although WSSV has a mortality rate of almost 100% and poses a serious threat to the shrimp farming industry, strategies for its prevention and treatment are extremely limited. In this study, we examined the efficacy of VP28, a recombinant WSSV protein expressed in Chlorella vulgaris (C. vulgaris), as an oral shrimp vaccine. When compared with the control group, in which WSSV had a cumulative mortality of 100%, shrimp treated with 5% VP28-expressing C. vulgaris in their feed only had a 20% cumulative mortality rate 12 days after the WSSV challenge. When compared with the nonvaccinated group, the transcription of anti-lipopolysaccharide factor, C-type lectin, and prophenoloxidase genes, which are involved in shrimp defense against WSSV infection, was upregulated 29.6 fold, 15.4 fold, and 11.5 fold, respectively. These findings highlight C. vulgaris as a potential host for industrial shrimp vaccine production.

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Seaweed polysaccharides as potential therapeutic agents against white spot syndrome virus (WSSV): a mini review

Cited by 12 publications

References 36 publications

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Valorization of the chemical diversity of the tropical red seaweeds Acanthophora and Kappaphycus and their applications in aquaculture: A review

Impact of Dietary Administration of Seaweed Polysaccharide on Growth, Microbial Abundance, and Growth and Immune-Related Genes Expression of The Pacific Whiteleg Shrimp (Litopenaeus vannamei)

Efficacy of White Spot Syndrome Virus Protein VP28-Expressing Chlorella vulgaris as an Oral Vaccine for Shrimp

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