Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review

Cotas, João; Pacheco, Diana; Gonçalves, Ana M. M.; Silva, Paulo; Carvalho, Loïc G.; Pereira, Leonel

doi:10.20517/2394-4722.2020.134

Cited by 25 publications

(32 citation statements)

References 217 publications

(323 reference statements)

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“…As demonstrated above, eckols can play important roles as anticancer metabolites, acting in several stages of cancer progression such as proliferative signaling, metastasis, cell cycle, resistance to cell death, evasion, angiogenesis and growth suppressor evasion [90][91][92][93][94][95]. Eckols show cytotoxicity against many cancerogenic cell lines and the compounds' selectivity towards cancer cell lines must be evaluated in hydrogel-based tumor models.…”

Section: In Vitro Vs In Vivo Questions On Eckolsmentioning

confidence: 99%

Call the Eckols: Present and Future Potential Cancer Therapies

et al. 2022

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In recent years, an increased interest in marine macroalgae bioactive compounds has been recorded due to their benefits to human health and welfare. Several of their bioactivities have been demonstrated, such as anti-inflammatory, antioxidant, anticarcinogenic, antibacterial and antiviral behavior. However, there still lacks a clear definition regarding how these compounds exert their bioactive properties. Of all the bioactive compounds derived from marine macroalgae, attention has been focused on phenolic compounds, specifically in phlorotannins, due to their potential for biomedical applications. Phlorotannins are a diverse and wide group of phenolic compounds, with several structural variations based on the monomer phloroglucinol. Among the diverse phlorotannin structures, the eckol-family of phlorotannins demonstrates remarkable bioactivity, notably their anti-tumoral properties. However, the molecular mechanisms by which this activity is achieved remain elusive and sparse. This review focuses on the described molecular mechanisms of anti-tumoral effects by the eckol family of compounds and the future prospects of these molecules for potential application in oncology therapies.

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Section: In Vitro Vs In Vivo Questions On Eckolsmentioning

confidence: 99%

Call the Eckols: Present and Future Potential Cancer Therapies

et al. 2022

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“…Brown seaweeds have complex polymers mostly of phlorotannins and phloroglucinol oligomers (1,3,5-trihydroxy benzene). Seaweed polyphenols have been linked to many biological activities, including antibacterial, anticancer, antidiabetic, anti-inflammatory, antiobesity, antioxidant, antiproliferative, antitumor, and antiviral effects (Montero et al, 2017;Gómez-Guzmán et al, 2018;Cotas et al, 2021).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Seaweeds: Bioactive Components and Properties, Potential Risk Factors, Uses, Extraction and Purification Methods

AMLANI

Yetgin

2022

Marine Science and Technology Bulletin

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Seaweeds, also known as macroalgae, are abundant sources of various vital bioactive components with a wide range of biological functions. They are sold commercially and are primarily used in the food industry, pharmaceuticals, cosmeceuticals, and other related industries. The diverse biological activities linked with bioactive compounds obtained from seaweeds have the potential to expand their health benefit value in the food and pharmaceutical industries. Studies revealed that seaweeds have the potential to be used as complementary medicine due to its variety of biological properties that have been shown to be therapeutic for health and disease management, such as antibacterial, anticoagulant, anticancer, antidiabetic, antiestrogenic, antihypertensive, antihyperlipidemic, antifungal, anti-inflammatory, antioxidant, antiobesity, antiviral, immunomodulatory, neuroprotective, thyroid stimulant, tissue healing properties, and many more. Although seaweeds are generally beneficial to humans, they may still pose possible health risks due to high iodine concentration and exposure to heavy metals and arsenic concentrations. However, information on this topic is still limited. With the great importance of seaweeds, various green extraction methods such as Microwave-assisted Extraction (MAE), Supercritical Fluid Extraction (SFE), Pressurized Solvents Extraction (PSE) and Enzyme-ssisted Extraction (EAE) were used as an alternative to the conventional method to isolate bioactive components and further purified using chromatographic technique analysis to ensure the purity of the extract. This review covers the following topics: general structure and characteristics of seaweeds, seaweed production, bioactive components and properties of seaweed, possible risk factors of seaweeds, applications of seaweeds, extraction, and purification of seaweed extracts.

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“…Particularly, people living long in coastal areas frequently used seaweed as a main dish, side dish, or soup (9). Consumption of seaweed supplies sufficient macro and micronutrients, which are essential to maintaining human health (10). Besides nutritional effects, seaweed has long been adopted as a drug in Traditional East Asian Medicine to alleviate the progression of multiple cancers (11).…”

Section: Introductionmentioning

confidence: 99%

Anti-colorectal cancer effects of seaweed-derived bioactive compounds

Xie

Zhu

et al. 2022

Front. Med.

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Seaweeds are classified as Chlorophyta, Rhodophyta, and Phaeophyta. They constitute a number of the most significant repositories of new therapeutic compounds for human use. Seaweed has been proven to possess diverse bioactive properties, which include anticancer properties. The present review focuses on colorectal cancer, which is a primary cause of cancer-related mortality in humans. In addition, it discusses various compounds derived from a series of seaweeds that have been shown to eradicate or slow the progression of cancer. Therapeutic compounds extracted from seaweed have shown activity against colorectal cancer. Furthermore, the mechanisms through which these compounds can induce apoptosis in vitro and in vivo were reviewed. This review emphasizes the potential utility of seaweeds as anticancer agents through the consideration of the capability of compounds present in seaweeds to fight against colorectal cancer.

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Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review

Cited by 25 publications

References 217 publications

Call the Eckols: Present and Future Potential Cancer Therapies

Call the Eckols: Present and Future Potential Cancer Therapies

Seaweeds: Bioactive Components and Properties, Potential Risk Factors, Uses, Extraction and Purification Methods

Anti-colorectal cancer effects of seaweed-derived bioactive compounds

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