Sebaceoma and Related Neoplasms With Sebaceous Differentiation

Misago, Noriyuki; Mihara, Ichiro; Ansai, Shin‐ichi; Narisawa, Yutaka

doi:10.1097/00000372-200208000-00002

Cited by 115 publications

(111 citation statements)

References 36 publications

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“…The verrucous variant of sebaceoma shows a connection between the sebaceous lobules and a hyperplastic infundibulum, a prominent granular layer, and basosquamous differentiation, features reminiscent of a seborrheic keratosis. 16 Unlike benign sebaceous neoplasms, sebaceous carcinoma shows features of malignancy: it is asymmetrical with poor circumscription, and has an infiltrative growth pattern, a preponderance of pleomorphic basaloid cells arranged in solid sheets, marked cytologic atypia, high mitotic activity, and variable tumor necrosis (Figure 3). 15 The basaloid tumor mass may contain scattered sebocytes.…”

Section: Pathologic Featuresmentioning

confidence: 99%

Muir-Torre Syndrome

Bhaijee

Brown

2014

Archives of Pathology &Amp; Laboratory Medicine

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Muir-Torre syndrome (MTS) is a rare autosomal-dominant genodermatosis characterized by sebaceous neoplasms and one or more visceral malignancies. Sebaceous tumors include sebaceous adenoma and carcinoma, which may be solitary or multiple. Visceral malignancies most often arise in the colorectum and endometrium. Because a subset of patients with phenotypic MTS will have germline mutations in the DNA mismatch repair genes hMSH2 and hMLH1, MTS is considered a phenotypic subtype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), in which inherited defects in DNA mismatch repair genes result in microsatellite instability. Pathologists have an important role in the early detection and initial diagnosis of MTS: identification of at-risk individuals allows appropriate screening and surveillance for visceral malignancies, thereby reducing morbidity and mortality. Herein, we describe the clinicopathologic features of MTS.

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Section: Pathologic Featuresmentioning

confidence: 99%

Muir-Torre Syndrome

Bhaijee

Brown

2014

Archives of Pathology &Amp; Laboratory Medicine

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“…Particularly problematic are the sebaceous neoplasms of Muir-Torre syndrome, which sometimes defy precise classification by the foregoing scheme. 52 …”

Section: Bcc With Sebaceous Differentiationmentioning

confidence: 99%

“…These include, but are not restricted, to keratotic BCC, 39 infundibulocystic BCC (Figure 12), 42,43 follicular BCC, [44][45][46][47] which shows collision features with pilomatricoma, pleomorphic BCC ( Figure 13), 48,49 BCC with eccrine differentiation, [50][51][52] BCC with sebaceous differentiation, the fibroepithelioma of Pinkus (Figure 14), 53 and the BCC with myoepithelial differentiation. 54 Keratotic BCC Also known as pilar BCC as it appears to differentiate along pilosebaceous lines, the keratotic BCC manifests large basaloid tumor nests that are rounded and show central keratinization and degeneration.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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“…These components are admixed in an often haphazard fashion. 24 The proportions of these components vary and have no set definition. Holocrine secretion may generate necrosis en masse, but necrosis of the tumor cells themselves is never conspicuous.…”

Section: Histopathologymentioning

confidence: 99%

“…Holocrine secretion may generate necrosis en masse, but necrosis of the tumor cells themselves is never conspicuous. [24][25][26] There is a verrucous or seborrheic keratosis-type lesion in which the sebaceous components connect to a hyperplastic epidermis through a proliferation of infundibular keratinocytes. 24 BCC with sebaceous differentiation (sebaceous epithelioma)…”

Section: Histopathologymentioning

confidence: 99%

Malignant adnexal neoplasms

2006

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Malignant cutaneous adnexal neoplasms are one of the most challenging areas of dermatopathology. Tumors of the pilosebaceous apparatus can occur as single-lineage neoplasms or may manifest as complex proliferations with multilineal differentiation patterns including not only the germinative component of the hair bulb, the inner or outer root sheath epithelium and the sebaceous gland and duct, but also the sweat duct components that relate to the apocrine secretory apparatus which empties into the follicle near the follicular bulge. Eccrine and apocrine neoplasms present a bewildering array of morphologies, which often defy precise classification. The purpose of this review is to discuss in detail the malignant neoplasms of the cutaneous adnexae and their benign and prognostically indeterminate mimics. Modern Pathology (2006) 19, S93-S126. doi:10.1038/modpathol.3800511Keywords: eccrine carcinoma; sebaceous neoplasia Malignant tumors of the pilosebaceous apparatus, their mimics and precursors IntroductionTumors of the pilosebaceous unit can occur in isolation or in combination with complex proliferations showing multilineal differentiation patterns encompassing those of sweat ducts, epidermis and stroma with its varied components. In this review, we will focus upon the malignant adnexal proliferations, considering benign entities mainly insofar as they impact the diagnostic approach to adnexal carcinoma. We will first turn to the malignant sebaceous neoplasms, their precursors and their mimics. Sebaceous adenoma Clinical FeaturesThe sebaceous adenoma is a benign neoplasm that manifests clinically as a pale yellow nodular lesion, typically of the face, that expresses itself clinically after the age of 50. Tumors range in size from o1 to 45 cm. [1][2][3][4][5][6] These lesions are associated with the Muir-Torre syndrome, comprising the coexpression of cutaneous neoplasms, including those of sebaceous type with well-differentiated squamous epithelial neoplasms, and visceral malignancies, including carcinomas of the breast, ovary, gastrointestinal tract and larynx. [7][8][9][10][11][12][13][14] An occasional patient may manifest a malignant lymphoma of nodal or extranodal type. 10,12,14 Sebaceous neoplasms in the setting of Muir-Torre syndrome are often difficult to classify, showing overlap features between all of the prototypic forms of sebaceous neoplasm ranging from hyperplasia to carcinoma. 13 HistologyThe prototypic sebaceous adenoma manifests 1-2 layers of germinitive cells which mature to form central sebocytes, and have an architecture comprising a sharply circumscribed sebaceous lobule surrounded by a compressed pseudocapsule of dermal stroma ( Figure 1a). The overlying epidermis may be attenuated, but sometimes forms a collarette around the peripheral aspect of the neoplasm. Unlike sebaceous hyperplasia, occasional mitoses may be seen in the lobules of a sebaceous adenoma and in concert with this nucleoli may be somewhat prominent, but the pleomorphism, hyperchromasia and individual cell necrosis of the se...

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Sebaceoma and Related Neoplasms With Sebaceous Differentiation

Cited by 115 publications

References 36 publications

Muir-Torre Syndrome

Muir-Torre Syndrome

Basal cell carcinoma: biology, morphology and clinical implications

Malignant adnexal neoplasms

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