Sebaceoma of the eyelid: a rare entity

Mittal, Ruchi; Tripathy, Devjyoti

doi:10.1016/j.jcjo.2014.03.014

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Only two previous reports allegedly describing a sebaceoma have appeared in the eye literature [16, 17], and both involved the eyelid margins. The first report [16] concerned a 53-year-old man who over 2 months had developed a left lower eyelid margin tumor that was entirely situated in the dermis.…”

Section: Discussionmentioning

confidence: 99%

“…The patient had a loss of DNA MMR protein expression for MMR MSH2 and MSH6, despite the fact that there was no family or personal history of visceral malignancy. The second case [17] occurred in an 81-year-old man with a marginal right upper eyelid nodule that had appeared over a 5-month period. Microscopically, it arose from the epidermis, and therefore not from the adnexal epithelium (the follicular-apocrine-sebaceous complex).…”

Section: Discussionmentioning

confidence: 99%

“…Sebaceomas usually develop in the scalp or on the face [15]; the periocular tissues appear to be an extremely rare site of origin. There are two reports of a sebaceoma of the eyelid margin [16, 17], and both were unassociated with the MTS. We describe for the first time a sebaceoma located in the tarsus that developed from a Meibomian gland.…”

Section: Introductionmentioning

confidence: 99%

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Sebaceoma of a Meibomian Gland of the Upper Eyelid

2020

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is a rare tumor of the eyelid and periocular skin. • Basaloid cells should constitute at least 50% of the cells in solid lesions, in contrast to the more differentiated sebaceous adenoma, which has a single outer layer of basaloid cells in a regular lobular architecture. • Like sebaceous adenoma, sebaceoma may be associated with the Muir-Torre syndrome. Novel Insights • Sebaceomas may arise in the Meibomian glands, as it did in a 74-year-old man. • The morphology of this tumor can be highly variegated, with interconnecting cords of haphazardly arranged basaloid and sebaceous cells (sebocytes) in a cystic cavity, as in the present case. • In the current case, both a positive family history and mismatch repair defects in the patient's protein expression for MLH1 and PMS2 were factors, indicating that eyelid sebaceoma can potentially be associated with the Muir-Torre syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%