Sebaceous adenitis

Ninety-seven pure-bred Akitas were examined clinically and histologically for sebaceous adenitis. The diagnosis was established histologically in 23 Akitas by demonstrating an inflammatory reaction targeted against the sebaceous glands or a reduction in the number of glands. The clinical course of sebaceous adenitis in the Akita was similar to that seen in other breeds. The first skin lesions occurred mainly on the dorsal midline and ears. Compared with the Poodle, the age at first onset of the disease was more variable and the hair loss affected mainly the undercoat. The progression of sebaceous gland destruction varied between dogs and was not seen in all cases. Because bud-like sebaceous gland proliferation could be identified, it seems that regeneration of the sebaceous glands may occur. An autosomal recessive inheritance appears to be possible. Apart from a genetic background, immune-mediated factors possibly influence the onset and course of sebaceous adenitis.

Section: Introductionmentioning

confidence: 99%

Sebaceous adenitis in the Akita: clinical observations, histopathology and heredity

Reichler¹,

Hauser²,

Schiller³

et al. 2001

“…Sebaceous adenitis is an inflammatory disease of the sebaceous glands, resulting in their destruction 1,2 . It is primarily seen in dogs but has also been reported in rabbits, cats, humans and one horse 3–7 . Currently, sebaceous adenitis is believed to be an immune‐mediated disease, but the pathogenesis is not fully understood 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Sebaceous adenitis in Havanese dogs: a retrospective study of the clinical presentation and incidence

Frazer

Schick²,

Lewis³

et al. 2011

Sebaceous adenitis is a suspected immune-mediated disease that targets and destroys sebaceous glands. This retrospective study evaluated the clinical presentation and incidence of sebaceous adenitis in Havanese dogs. Sebaceous adenitis was diagnosed in 35% (12 of 34) of Havanese dogs presented over a 5-year period. Onset of clinical signs occurred during young adulthood. Follicular casts were present in 92% (11 of 12) of affected dogs. Other common clinical signs included alopecia and hypotrichosis. The trunk, head and ears were commonly affected, with 67% (8 of 12) of cases having pinnal and ⁄ or external ear canal involvement. Secondary pyoderma was seen in 42% (5 of 12) of dogs. Histopathology revealed absent sebaceous glands in 83% (10 of 12) and a lymphoplasmacytic periadnexal infiltrate in 92% (11 of 12) of samples. Treatment included multiple modalities. Ciclosporin was prescribed in 83% (10 of 12) of cases. Other systemic therapies included vitamin A and fatty acid supplementation. Topical therapies included antiseborrhoeic shampoos and sprays, and oil soaks. Follow-up ranging from 2 months to 3 years was obtained in 67% (8 of 12) of dogs. Improvement ranged from minimal to marked, with better clinical response associated with longer duration of treatment. Owners with follow-up of more than 1 year commonly reported occasional flares of the clinical signs. This study found that sebaceous adenitis was a common diagnosis in Havanese dogs, that the ears were commonly affected and that a lymphoplasmacytic periadnexal infiltrate associated with absent sebaceous glands was frequently seen on dermatohistopathological examination.

“…Idiopathic sebaceous adenitis (ISA), which has been described in dogs, humans, cats, rabbits and horses, 1–5 is a skin disease of unknown cause and pathogenesis, in which cell‐mediated destruction of sebaceous glands is hypothesized 2,6 . In the dog, ISA has been documented in both purebreds and mongrels, 1 although a strong breed predilection for standard poodles, Samoyeds, Akitas, vizslas and dachshunds suggests a genetic basis 2 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Inflammatory dermal disorders in which sebaceous glands are destroyed as secondary targets include sterile granuloma and pyogranuloma syndrome, juvenile sterile granulomatous dermatitis and lymphadenitis, Vogt-Koyanagi-Harada-like syndrome, demodicosis and canine leishmaniosis (CL). 1 Idiopathic sebaceous adenitis (ISA), which has been described in dogs, humans, cats, rabbits and horses, [1][2][3][4][5] is a skin disease of unknown cause and pathogenesis, in which cell-mediated destruction of sebaceous glands is hypothesized. 2,6 In the dog, ISA has been documented in both purebreds and mongrels, 1 although a strong breed predilection for standard poodles, Samoyeds, Akitas, vizslas and dachshunds suggests a genetic basis.…”

Section: Introductionmentioning

confidence: 99%

Histopathological differences between canine idiopathic sebaceous adenitis and canine leishmaniosis with sebaceous adenitis

Bardagí

Fondevila

Zanna

et al. 2010

Sebaceous adenitis (SA) may be idiopathic (ISA) or associated with other disorders. The purpose of the present study was to compare the cutaneous histopathology of SA in cases in which Leishmania organisms were detected by immunohistochemistry (IHC) with that of cases diagnosed as ISA. Skin sections of 29 patients were evaluated histologically and divided into two groups, one characterized by several epidermal and subepidermal lesions, a granulomatous to pyogranulomatous nodular to diffuse dermatitis involving the sebaceous glands and a positive IHC for Leishmania spp. The other group was characterized by orthokeratotic hyperkeratosis, follicular keratosis with different degrees of pyogranulomatous to granulomatous SA, lack of nodular dermatitis and a negative IHC for Leishmania spp. Hidradenitis was present in both groups. From these results it can be concluded that SA in canine Leishmaniosis (CL) is usually present together with a nodular to diffuse dermal infiltrate and epidermal and subepidermal lesions, and that SA in the absence of dermal inflammation is probably not associated with or suggestive of CL, even in regions where the disease is endemic.