Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options

Dowell-Esquivel, Caitlin; Lee, Raphael; DiCaprio, Robert C.; Nouri, Keyvan

doi:10.1007/s00403-023-02747-7

Cited by 4 publications

(1 citation statement)

References 68 publications

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“…Rare types of non-melanoma skin cancer, such as sebaceous carcinoma, can pose a significant diagnostic challenge [ 22 , 23 , 24 ]. Cazzato et al’s study revealed that Preferentially expressed Antigen in Melanoma (PRAME) can be useful for the subclassification of different grades of sebaceous carcinoma [ 25 ].…”

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confidence: 99%

Diagnosis of Skin Cancer: From the Researcher Bench to the Patient’s Bedside

Holló,

Lengyel,

Bánvölgyi

et al. 2024

JCM

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confidence: 99%

Diagnosis of Skin Cancer: From the Researcher Bench to the Patient’s Bedside

Holló,

Lengyel,

Bánvölgyi

et al. 2024

JCM

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Sebaceous Gland Carcinoma

Zloto,

Rosner

2024

Clinical Ophthalmic Oncology

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Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review

Yadlapati,

Rosa‐Nieves,

Mehta

et al. 2024

Int J Dermatology

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Sebaceous carcinoma (SC) is a rare neoplasm affecting periocular and extraocular sites. If inadequately treated, it can recur and cause morbidity. Specific management guidelines have not been established. Wide local excision (WLE) has been traditionally used; however, Mohs micrographic surgery (MMS) can be advantageous because of complete margin assessment and tissue‐sparing nature. This analysis aims to systematically review the surgical modalities used for the management of SC. Articles meeting eligibility criteria were identified using MEDLINE (via PubMed), Embase, Cochrane, and Scopus databases. All studies investigating surgical management of SC with WLE or MMS were considered. Seventy studies met inclusion criteria, including retrospective cohort studies, case series, and case reports. WLE was used in 32 studies, MMS in 29, and MMS and WLE in 9. Subgroup analysis showed that MMS has lower recurrence rates. For WLE, local, regional, and distant recurrence rates were 23.4%, 13.3%, and 11.0%, respectively, and for MMS, 6.8%, 4.3%, and 4.6%, respectively. Patients treated with WLE were more likely to have local recurrence than patients treated with MMS (P = 0.001). WLE cases were more likely to have a regional (P = 0.05) and distant recurrence (P = 0.001). Limitations of the study include heterogeneity of case reports, case series, and retrospective studies, variable follow‐up times between the two groups, and large tumors included in the WLE category. In addition, disease‐specific survival was not evaluated. MMS cases showed a superior outcome for local, regional, and distant recurrence, making it a good option for the management of SC.

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Sebaceous carcinoma: an updated review of pathogenesis, diagnosis, and treatment options

Cited by 4 publications

References 68 publications

Diagnosis of Skin Cancer: From the Researcher Bench to the Patient’s Bedside

Diagnosis of Skin Cancer: From the Researcher Bench to the Patient’s Bedside

Sebaceous Gland Carcinoma

Treatment of sebaceous carcinoma with Mohs micrographic surgery versus wide local excision: a systematic review

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