Sebaceous carcinoma in children

Omura, Nayomi E.; Collison, Daniel W.; Perry, Ann E.; Myers, Laura M.

doi:10.1067/mjd.2002.114615

Cited by 23 publications

(17 citation statements)

References 9 publications

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“…1 The incidence in males equals that in females, and the mean age of diagnosis for sporadic sebaceous carcinoma is 70 years. 2,3 Lesions have a tendency to be locally aggressive. There-fore, excision margins of 5 to 6 cm have been recommended when the lesion is treated by traditional excision.…”

Section: Discussionmentioning

confidence: 99%

“…There-fore, excision margins of 5 to 6 cm have been recommended when the lesion is treated by traditional excision. [1][2][3] Metastases occur most commonly to the draining lymph node basin but have also been reported in the abdomen, liver, small bowel, urinary tract, lung, and brain. 2 Muir-Torre syndrome is defined as the occurrence of a characteristic cutaneous neoplasm with the prior, concurrent, or sequential diagnosis of a visceral neoplasm.…”

Section: Discussionmentioning

confidence: 99%

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Aggressive Extraocular Sebaceous Carcinoma in a 52-Year-Old Man

Reina

Parry

2006

Dermatol Surg

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aggressive Extraocular Sebaceous Carcinoma in a 52-Year-Old Man

Reina

Parry

2006

Dermatol Surg

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“…Sebaceous carcinoma can be misdiagnosed because it is clinically unimpressive and thus tends to masquerade as a benign entity 9,10 . In addition to its varied clinical appearance, the histopathology of sebaceous carcinoma can also be diverse, and a delay in diagnosis or misdiagnosis following a biopsy is not uncommon 4,5,7–11 . In our patient, a benign lesion was suspected and a diagnosis of sebaceous carcinoma was made only after microscopical analysis.…”

Section: Discussionmentioning

confidence: 80%

“…A link between Muir‐Torre syndrome and pediatric sebaceous carcinoma has not been established, 6 but an evaluation for the syndrome is advisable once sebaceous carcinoma has been diagnosed 7 . Reports in the literature indicate that two cases of childhood sebaceous carcinoma were associated with prior radiotherapy for retinoblastoma 8 . We were not able to elicit a history of irradiation from our patient.…”

Section: Discussionmentioning

confidence: 88%

A case of sebaceous carcinoma diagnosed in an adolescent male

Mirzamani

Sundram

2011

Journal of Cutaneous Pathology

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Sebaceous carcinoma is an uncommon and potentially aggressive malignancy that exhibits sebaceous differentiation. Approximately 75% of cases arise in the periocular region. Sebaceous carcinoma is rare in the pediatric population and its presentation in this age group is not well documented in the dermatopathology literature. We report the case of a 15-year-old male with sebaceous carcinoma who was first seen with a nodular lesion involving the skin of the left orbit/temporal area. A shave biopsy was performed which showed an infiltrative proliferation of basaloid cells that focally exhibited sebaceous differentiation, including the formation of incipient sebocytes. Immunohistochemically, the tumor cells expressed epithelial membrane antigen (EMA) and CK5/6, while a lack of Ber-EP4 was observed. Based upon these attributes, the diagnosis of sebaceous carcinoma was rendered. Subsequent immunohistochemical analysis for a possible DNA mismatch repair enzyme defect revealed that all four mismatch repair gene products showed retained expression, thereby providing no support for the presence of underlying Muir-Torre syndrome. Sebaceous carcinomas are exceptional in the pediatric age group and are rarely documented in the dermatopathology literature. Knowledge that this adult carcinoma can occur mostly in the pediatric age group may aid in the recognition of this uncommon malignancy.

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“…Wick et al [4] and others believe that ocular and extra-ocular sebaceous carcinoma share a similar and definite risk of metastases to regional lymph nodes, bones, and viscera. Extra-ocular sebaceous carcinomas had been considered aggressive, although they are now associated with a far better prognosis than ocular localization [2,6,[9][10][11][12][13][14][15]. Some have argued against this contention, saying that distant metastases and tumorrelated death are as common in cases of extra-ocular sebaceous carcinoma as in ocular cases [16][17][18].…”

Section: Discussionmentioning

confidence: 97%